The most comprehensive analysis of its kind suggests that there is a strong link between non-HDL cholesterol levels and long-term risk for cardiovascular disease in people aged under 45 years, not just at older ages., according to The Lancet.
- Study is the most comprehensive analysis of long-term risk for cardiovascular disease related to non-high-density lipoprotein (non-HDL) cholesterol – including almost 400,000 people from 19 countries who were followed for up to 43.5 years (median 13.5 years follow-up) between 1970 to 2013.
- This longer-term evidence may be particularly important in people aged under 45 years.
- Depending on cholesterol level and number of cardiovascular risk factors, men and women aged under 45 years have a 12-43% or 6-24% risk (respectively) of having fatal or non-fatal heart disease or stroke by the age of 75 years.
- If non-HDL cholesterol levels were halved, women and men younger than 45 years with starting levels of non-HDL cholesterol between 3.7-4.8 mmol/liter and who had two additional cardiovascular risk factors could reduce their risk from around 16% to 4%, and from around 29% to 6%, respectively.
The observational and modelling study which used individual-level data from almost 400,000 people, published in The Lancet, extends existing research because it suggests that increasing levels of non-HDL cholesterol may predict long-term cardiovascular risk by the age of 75 years. Past risk estimates of this kind are based on 10-year follow-up data.