Cognitive decline is a major concern of the aging population. Already, Alzheimer’s disease affects approximately 5.4 million Americans and 30 million people globally. Without effective prevention and treatment, the prospects for the future are bleak. By 2050, it is estimated that 160 million people globally will have the disease, including 13 million Americans, leading to potential bankruptcy of the Medicare system. Unlike several other chronic illnesses, Alzheimer’s disease is on the rise–recent estimates suggest that Alzheimer’s disease has become the third leading cause of death in the United States behind cardiovascular disease and cancer. Since its first description over 100 years ago, Alzheimer’s disease has been without effective treatment.
While researchers continue to seek out a cure, it is becoming clear that there are effective treatment options. More and more research supports the conclusion that Alzheimer’s disease is not a disease of only Beta Amyloid plaques and Tao tangles but a complex and systemic disease. In this study of patients with varying levels of cognitive decline, it is demonstrated how a precision and personalized approach results in either stabilization or improvement in memory.
Affirmativ Health sought to determine whether a comprehensive and personalized program, designed to mitigate risk factors of Alzheimer’s disease could improve cognitive and metabolic function in individuals experiencing cognitive decline. Findings provided evidence that this approach can improve risk factor scores and stabilize cognitive function.
People with lower household wealth (or socioeconomic status) have a higher risk of many diseases, including heart disease, diabetes, and depression. They also have shorter lifespans. Some lifestyle factors may play a role. For example, people with lower incomes have higher rates of smoking. However, other factors—including chronic stress and reduced access to resources—also likely contribute, according to the National Institute on Aging (NIA).
Less is known about how socioeconomic status influences the general aging process. To look more closely at this question, Drs. Andrew Steptoe and Paola Zaninotto from University College London followed more than 5,000 adults, aged 52 and older, for 8 years beginning in 2004. The team broke the study participants into four groups based on household wealth. Continue reading →
Do you know that feeling you get in your gut? It turns out your gut may really be trying to tell you something. Our microbiome – the 100 trillion bacteria and organisms living in our gut – appears to have a profound influence on our health and risk of disease. And early scientific studies show there may be a link between the microbiome and the brain that could impact the risk of Alzheimer’s and other brain diseases.
The microbiome is a collection of bacteria, viruses and fungi that live mostly in our intestinal system. They play an important role in digestion and the production of certain vitamins, and they support our immune system. Researchers around the world study the gut microbiome, especially those bacteria unique to individuals, to learn more about their influence on our overall health.
It’s never too late to lace up some sneakers and work up a sweat for brain health, according to a study published in the May 13, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study suggests older adults, even couch potatoes, may perform better on certain thinking and memory tests after just six months of aerobic exercise.
“As we all find out eventually, we lose a bit mentally and physically as we age. But even if you start an exercise program later in life, the benefit to your brain may be immense,” said study author Marc J. Poulin, Ph.D., D.Phil., from the Cumming School of Medicine at the University of Calgary in Alberta, Canada. “Sure, aerobic exercise gets blood moving through your body. As our study found, it may also get blood moving to your brain, particularly in areas responsible for verbal fluency and executive functions. Our finding may be important, especially for older adults at risk for Alzheimer’s and other dementias and brain disease.”
With more than 30 million Americans diagnosed with diabetes, and another 87 million diagnosed with obesity, both conditions have become national epidemics.
The two diseases cause a number of complications, including neuropathy, which causes damage to the peripheral nerves. Neuropathy is characterized by numbness or tingling and can sometimes be accompanied by pain.
By the time people reach a certain age, they’ve accumulated enough life experience to have plenty of stories to tell about life “back in their day.”
However, a new study suggests that the older a person is, the less likely they are to share memories of their past experiences. And when they do share memories, they don’t describe them in as much detail as younger people do.
The results of the study, conducted by researchers at the University of Arizona and published in the journal Frontiers in Human Neuroscience, echo previous findings from lab-based research suggesting that memory sharing declines with age.
The UArizona study came to the conclusion in a new way: by “eavesdropping” on older adults’ conversations “in the wild.”
Most of us know that feeling of trying to retrieve a memory that does not come right away. You might be watching a romantic comedy featuring that famous character actor who always plays the best friend and find yourself unable to recall her name (it’s Judy Greer). While memory retrieval has been the subject of countless animal studies and other neuroimaging work in humans, exactly how the process works — and how we make decisions based on memories — has remained unclear.
In a new study published in the June 26 issue of the journal Science, a collaborative team of neuroscientists from Caltech and Cedars-Sinai Medical Center in Los Angeles has identified different sets of individual neurons responsible for memory-based decision-making, a hallmark of the human brain’s flexibility.
Researchers have found a way to design an antibody that can identify the toxic particles that destroy healthy brain cells – a potential advance in the fight against Alzheimer’s disease.
Their method is able to recognize these toxic particles, known as amyloid-beta oligomers, which are the hallmark of the disease, leading to hope that new diagnostic methods can be developed for Alzheimer’s disease and other forms of dementia.
The team, from the University of Cambridge, University College London and Lund University, designed an antibody which is highly accurate at detecting toxic oligomers and quantifying their numbers. Their results are reported in the Proceedings of the National Academy of Sciences (PNAS).
Older adults with depression may be at much higher risk of remaining depressed if they are experiencing persistent or worsening sleep problems, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.
The researchers, who published their findings online April 30 in the journal Sleep, analyzed data from almost 600 people over 60 years old who visited primary care centers in the Northeast U.S. All patients met clinical criteria for major or minor depression at the outset of the study. Continue reading →
This guide focuses on cognitive health and what you can do to help maintain it. The following steps can help you function every day and stay independent—and they have been linked to cognitive health, too.
Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge. The researchers say it offers hope for potential new treatments for several types of dementia.
Inflammation is usually the body’s response to injury and stress – such as the redness and swelling that accompanies an injury or infection. However, inflammation in the brain – known as neuroinflammation – has been recognized and linked to many disorders including depression, psychosis and multiple sclerosis. It has also recently been linked to the risk of Alzheimer’s disease.
In a study published in the journal Brain, a team of researchers at the University of Cambridge set out to examine whether neuroinflammation also occurs in other forms of dementia, which would imply that it is common to many neurodegenerative diseases.
UNIGE researchers have shown that the decline in cognitive abilities after 50 years of age results in a decline in physical activity, and that – contrary to what has been suggested by the literature to date – the inverse relationship is much weaker.
Someone dies somewhere in the world every 10 seconds owing to physical inactivity – 3.2 million people a year according to the World Health Organization (WHO). From the age of 50, there is a gradual decline not just in physical activity but also in cognitive abilities since the two are correlated. But which of them influences the other? Does physical activity impact on the brain or is it the other way around? To answer this question, researchers from the University of Geneva (UNIGE), Switzerland, and the NCCR Lives Swiss National Center of Competence in Research used a database of over 100,000 people aged 50-90 whose physical and cognitive abilities were measured every two years for 12 years. The findings, which are published in the journal Health Psychology, show that – contrary to what was previously thought – cognitive abilities ward off inactivity much more than physical activity prevents the decline in cognitive abilities. All of which means we need to prioritize exercising our brains. Continue reading →
Truth be told I never heard of Lion’s mane mushrooms before today. However, this article in Medical News Today piqued my curiosity. I would like to hear from any readers who may have had experience with the mushrooms in one form or another.
Lion’s mane mushrooms (Hericium erinaceus) are white, globe-shaped fungi that have long, shaggy spines. People can eat them or take them in the form of supplements. Research suggests that they may offer a range of health benefits, including reduced inflammation and improved cognitive and heart health. Continue reading →
As a senior citizen who has had family members suffer from dementia and Alzheimer’s Disease, I want to know everything I can about aging and cognition, so this study from Florida Atlantic University piqued my interest.
The neighborhood environment may positively or negatively influence one’s ability to maintain cognitive function with age. Since older adults spend less time outside, the neighborhood environment increases in importance with age. Studies suggest physical aspects of the neighborhood such as the availability of sidewalks and parks, and more social and walking destinations, may be associated with better cognitive functioning. Beneficial neighborhood environments can provide spaces for exercise, mental stimulation, socializing and reducing stress. To date, few studies have examined how the neighborhood’s physical environment relates to cognition in older adults. Continue reading →
Because of the dementia and Alzheimer’s Disease in my family, I have an appetite for information on impaired cognition. Following comes from a study by the VA San Diego Healthcare System. Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.
The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology.
Participants had brain scans at the start of the study to determine levels of amyloid plaques in the brain, and then yearly scans for four years. Image is in the public domain.
“Our research was able to detect subtle thinking and memory differences in study participants and these participants had faster amyloid accumulation on brain scans over time, suggesting that amyloid may not necessarily come first in the Alzheimer’s disease process,” said study author Kelsey R. Thomas, PhD, of the VA San Diego Healthcare System in San Diego. “Much of the research exploring possible treatments for Alzheimer’s disease has focused on targeting amyloid. But based on our findings, perhaps that focus needs to shift to other possible targets.” Continue reading →