Having lost three family members to Alzheimer’s Disease and dementia, I was fascinated by this information from researchers in Berlin.
A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM) and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer’s.
The adenosine receptor belongs to the GPCR family (G Protein-Coupled Receptors), a large group of proteins located in cell membranes, which are key in the transmission of signals and communication between cells. GPCRs are therefore involved in the majority of important physiological processes, including the interpretation of sensory stimuli such as vision, smell, and taste, the regulation of the immune and inflammatory system, and behavior modulation. Continue reading
A reader who happens to be in the business of health, Velocity Athletic Training Radio, enjoys my blog and asked me if I would like to discuss it with her on the radio. You remember radio, don’t you? If you would like to hear it click the link below.
Here is some good news for chocolate lovers. Researchers have found that cocoa flavanols could boost cognitive function within just a few hours of consumption. Perhaps the best news is that elderly adults reaped the best benefits.
Additionally, researchers found that regular, long-term intake of cocoa flavanols may protect against cognitive decline.
Writing in Medical News Today, Honor Whiteman reported flavanols are naturally occurring compounds found in various types of plants, with some of the highest levels found in the beans of the cocoa tree.
Good news for tea drinkers or all stripes. A study in the December 2016 Journal of Nutrition, Health & Aging showed that drinking tea frequently is associated with a lower risk of dementia, especially for people who are genetically predisposed to the disease, Harvard Men’s Health Watch reported.
Researchers followed 957 older adults, average age 65, who were part of the Singapore Longitudinal Aging Study. Of these, 69% drank tea on a frequent basis. After a five-year period, the researchers found that the tea drinkers had a 50% lower risk of dementia. This is consistent with earlier findings that showed tea consumers scored higher on various cognitive tests.
Experts in aging and Alzheimer’s disease are conducting a national clinical study to determine if exercise may be an effective non-drug intervention for maintaining cognitive fitness.
The Rush Alzheimer’s Disease Center at Rush University Medical Center is the only site in Illinois, and one of only 15 sites across the United States leading the Exercise in Adults With Mild Memory Problems (EXERT) study, which is trying to determine if exercise can slow the progress of memory loss and cognitive impairment in older adults.
Neuroscientists are collaborating with the YMCA to provide individualized, one-on-one exercise programs and personal training to study participants. Rush will be working with the McGaw YMCA in Evanston, Illinois, to provide 45-minute personal training sessions for one year.
Adults with memory issues may avoid being active when they need it most
“We want to see if a personalized program implemented in the community and prescribed by health care providers can be an effective therapy for people with memory issues,” said Dr. Neelum Aggarwal, associate professor of neurology and principal investigator of the EXERT study at Rush. Continue reading
If you would like more detail on items above, please check out the following posts:
Certainly one of the best concepts I have learned in producing this blog is that the brain benefits from exercise. It is the first item on the infographic above – Stay Active. I have written a Page on it – Important facts about your brain (and exercise benefits.)
Regarding the “Don’t be Salty” entry, it is important to keep in mind that most of the damaging salt we consume comes in the form of processed foods. Pay attention to the salt/sodium content in the foods you consume.
Stress damages us in many ways. I have written about it numerous times. You can search S T R E S S in the tags for more. One of the best posts on it is: Super tools for handling stress that I wrote in 2011. Check it out.
Last, but not least, ‘Be happy.’ I have covered the benefits of happiness in lots of posts. I think my Page – Positive psychology – What’s it all about? will also prove valuable information.
Moderate-intensity exercise can help improve your thinking and memory in just six months.
Happy days! More positive information on the benefits to the brain garnered from physical exercise! This time from Harvard Medical School.
You probably already know that exercising is necessary to preserve muscle strength, keep your heart strong, maintain a healthy body weight, and stave off chronic diseases such as diabetes. But exercise can also help boost your thinking skills. “There’s a lot of science behind this,” says Dr. Scott McGinnis, an instructor in neurology at Harvard Medical School. Continue reading
Because my family history includes both Alzheimer’s Disease and dementia, I am fascinated by every aspect of the brain and its functions. The following is from Neuroscience News.
The human brain is much better than previously thought at discovering and avoiding disease, a new study led by researchers at Karolinska Institutet in Sweden reports. Our sense of vision and smell alone are enough to make us aware that someone has a disease even before it breaks out. And not only aware – we also act upon the information and avoid sick people. The study is published in the scientific journal Proceedings of the National Academy of Sciences (PNAS).
By injecting harmless sections of bacteria, the researchers activated the immune response in participants, who developed the classic symptoms of disease – tiredness, pain and fever – for a few hours, during which time smell samples were taken from them and they were photographed and filmed. The injected substance then disappeared from their bodies and with it the symptoms. NeuroscienceNews.com image is for illustrative purposes only.
With both Alzheimer’s and dementia in my family, I am interested in all research on the subject.
Tufts reported the following in its Health and Nutrition Letter.
Could a trimmer waistline in middle age help you avoid Alzheimer’s later in life? That’s the suggestion of a study, published in Molecular Psychiatry, from the National Institute on Aging. Researchers analyzed data on 1,394 participants in a long-running study of aging, followed for an average of 14 years, who regularly underwent cognitive testing. A total of 142 participants developed Alzheimer’s disease during the study.
After adjusting for other factors, each additional point of body-mass index (BMI) at age 50 was associated with an earlier onset of Alzheimer’s of 6.7 months. “Our findings clearly indicate that higher adiposity at midlife is associated with a long-lasting effect on accelerating the clinical course of Alzheimer’s disease,” Madhav Thambisetty, MD, PhD, and colleagues concluded.
The study was not designed to prove cause and effect, however, and it’s not clear whether the association between obesity and Alzheimer’s risk might begin even earlier. It’s also true that newly diagnosed Alzheimer’s patients tend to weigh less than normal, not more.
To read further on the subject, please check out my Page – Important facts about your brain – (and exercise benefits).
Really good information in this.
To read more on lining your head up straight, check out my Page – Positive psychology – What’s it all about?
Our Better Health
You probably know that exercise and diet are important when it comes to aging well. But there is something else you control that can help you along: a positive attitude.
Research shows more and more that your approach to life may be just as important in making your “golden years” your best years.
Aging: It’s in Your Mind
Growing older brings with it some natural changes (think those creaky knees). But folks who see good years ahead and who don’t accept stereotypes about aging — such as you’re less useful — may actually live longer.
And there’s science to back that up.
One study found that thinking positively about getting older can extend lifespan by 7.5 years. And that’s after accounting for things such as gender, wealth, and overall health. Some 660 women and men in Ohio joined this study, and they were monitored for more than 20 years.
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I am all for living a long and healthy life and this blog is filled with suggestions on achieving that. But, besides having a functional brain and body in our senior years, we also want to be happy about it. Harvard has studied a group of men and boys over the past 78 years in what is one of the longest studies of adult life ever done.
“The Harvard Study of Adult Development has tracked the lives of 724 men from the time they were teenagers into old age — 268 Harvard College sophomores, and 456 boys from Boston’s inner city.”
Here are five of the big lessons they learned about what contributes to a good life.
Lesson 1: Happy childhoods matter
Having warm relationships with parents in childhood predicts that you will have warmer and more secure relationships with those closest to you in adulthood. We found that warm childhoods reached across decades to predict more secure relationships with spouses at age 80. A close relationship with at least one sibling in childhood predicts that people are less likely to become depressed by age 50. And warmer childhood relationships predict better physical health in adulthood all the way into old age. Continue reading
As a senior citizen, I am aware of the aging process going on in both my body and my brain. I exercise to help preserve both. Here are some super suggestions from Harvard HEALTHbeat on bolstering the memory aspect of your brain.
Your daily habits and lifestyle — what you eat and drink, whether you exercise, how stressed you are, and more — affect your mental health every bit as much as your physical health. A growing body of research indicates that regular exercise and a healthful diet can help protect your memory from aging-related decline. Continue reading
Video games which involve physical activity significantly boost our brain health as we get older, according to new research led by University of Manchester experts.
Study authors Dr Emma Stanmore and Joseph Firth say systems that use physical activity for gaming such as Wii, and Xbox Kinect can boost brain functioning in people with neurological impairment, as well as keeping our minds healthy and active as we age.
In the first ever analysis of all published evidence, the researchers aggregated data from 17 clinical trials examining the effects of active gaming on cognitive functioning across 926 people. Continue reading
The Defense Advanced Research Projects Agency (DARPA) is working with seven U.S. universities and elements of the Air Force and Army on research that seeks to stimulate the brain in a non-invasive way to speed up learning.
DARPA announced the Targeted Neuroplasticity Training, or TNT, program last March, and work now has begun on the effort to discover the safest and most effective ways to activate a natural process called “synaptic plasticity.”
Plasticity is the brain’s ability to strengthen or weaken its neural connections to adapt to changes in the environment. For TNT Program Manager Dr. Doug Weber, such plasticity is about learning.
“We’re talking about neural plasticity, or how the neurons, which are the working units in the brain, how their function changes over time as we train on new skills,” he said during a recent interview with Department of Defense News.
Targeted Neuroplasticity Training
TNT research focuses on a specific kind of learning called cognitive skills training. People use cognitive skills to do things like pay attention, process information, do several things at once, detect and understand patterns, remember instructions, organize information and much more. Continue reading
Eat less; move more; live longer is the mantra of this blog. Of course the most important element in living longer is having a fully functioning brain. The BBC just filed a wonderful story supporting that outcome.
Doing moderate exercise several times a week is the best way to keep the mind sharp if you’re over 50, research suggests.
Thinking and memory skills were most improved when people exercised the heart and muscles on a regular basis, a review of 39 studies found.
This remained true in those who already showed signs of cognitive decline.
Taking up exercise at any age was worthwhile for the mind and body, the Australian researchers said.
Exercises such as T’ai Chi were recommended for people over the age of 50 who couldn’t manage other more challenging forms of exercise, the study in the British Journal of Sports Medicine said.
Having had three family members who suffered from some form of dementia I am highly motivated to find out all I can about this scourge that devastates mostly seniors. The following is from the Rush Alzheimer’s Disease Center.
Genes help cognition withstand damage in brain from Alzheimer’s, Parkinson’s
The pathologies (damage) in the brain that stroke, Alzheimer’s disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it.
Now researchers have discovered two genes, known as UNC5C and ENC1, that are associated with aging individuals having better memory and brain function than would be expected, given the amount of pathologies that accumulated in their brains. They reported their findings in an article published today in the journal PLOS Medicine. Continue reading