Cardiovascular disease is leading cause of death worldwide; High blood pressure, high cholesterol, dietary risks and air pollution leading causes of cardiovascular disease worldwide.
Key takeaways from the report:
Ischemic heart disease is the leading cause of cardiovascular death, accounting for 9.44 million deaths in 2021 and 185 million DALYs.
High systolic blood pressure remains the leading modifiable risk factor for premature cardiovascular deaths, accounting for 10.8 million CV deaths and 11.3 million deaths overall in 2021. The all-cause DALYs (disability-adjusted life years) due to high blood pressure were 2,770 per 100,000 people.
Dietary risks accounted for 6.58 million CV deaths and 8 million deaths overall in 2021. Dietary risks include food types that are under-consumed globally (fruits, vegetables, legumes, whole grains, nuts and seeds, milk, fiber, calcium, omega-3 fatty acids and poly unsaturated fatty acids) and over-consumed (red and processed meats, sugar-sweetened beverages, trans-fatty acids and sodium). All-cause DALYs due to dietary risks were 2,340 per 100,000 people.
Central Asia, Central Sub-Saharan Africa and Eastern Europe were the regions with the highest rates of CVD burden attributable to elevated systolic blood pressure. The regions with the highest rates of CVD burden attributable to dietary risk were Central Asia, Oceania and Eastern Europe.
Central Asia had the highest age-standardized total CVD mortality at 516.9 deaths per 100,000. In contrast, high-income Asia Pacific had the lowest age-standardized total CVD mortality at 76.6 deaths per 100,000 people.
Since 1990, Australasia had the largest percent reduction (64.2%) in age-standardized CVD per 100,000 out of all other regions. This percent decrease was highest in ischemic heart disease at 71.8%.
Observational research has suggested that light alcohol consumption may provide heart-related health benefits, but in a large study published in JAMA Network Open, alcohol intake at all levels was linked with higher risks of cardiovascular disease. The findings, which are published by a team led by researchers at Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard, suggest that the supposed benefits of alcohol consumption may actually be attributed to other lifestyle factors that are common among light to moderate drinkers.
The study included 371,463 adults—with an average age of 57 years and an average alcohol consumption of 9.2 drinks per week—who were participants in the UK Biobank, a large-scale biomedical database and research resource containing in-depth genetic and health information. Consistent with earlier studies, investigators found that light to moderate drinkers had the lowest heart disease risk, followed by people who abstained from drinking. People who drank heavily had the highest risk. However, the team also found that light to moderate drinkers tended to have healthier lifestyles than abstainers—such as more physical activity and vegetable intake, and less smoking. Taking just a few lifestyle factors into account significantly lowered any benefit associated with alcohol consumption.
High blood pressure, or hypertension, is the leading modifiable risk factor for cardiovascular diseases and premature death worldwide. And key to treating patients with conditions ranging from chest pain to stroke is understanding the intricacies of how the cells around arteries and other blood vessels work to control blood pressure. While the importance of metals like potassium and calcium in this process are known, a new discovery about a critical and underappreciated role of another metal – zinc – offers a potential new pathway for therapies to treat hypertension.
All the body’s functions depend on arteries channeling oxygen-rich blood – energy – to where it’s needed, and smooth muscle cells within these vessels direct how fast or slow the blood gets to each destination. As smooth muscles contract, they narrow the artery and increase the blood pressure, and as the muscle relaxes, the artery expands and blood pressure falls. If the blood pressure is too low the blood flow will not be enough to sustain a person’s body with oxygen and nutrients. If the blood pressure is too high, the blood vessels risk being damaged or even ruptured.
Consuming a plant-based diet can lower blood pressure even if small amounts of meat and dairy are consumed too, according to new research from the University of Warwick.
Published online by a team from Warwick Medical School in the Journal of Hypertension, they argue that any effort to increase plant-based foods in your diet and limit animal products is likely to benefit your blood pressure and reduce your risk of heart attacks, strokes and cardiovascular disease. They conducted a systematic review of previous research from controlled clinical trials to compare seven plant-based diets, several of which included animal products in small amounts, to a standardised control diet and the impact that these had on individuals’ blood pressure.
Plant-based diets support high consumption of fruits, vegetables, whole grains, legumes, nuts and seeds, limiting the consumption of most or all animal products (mainly meat and diary). (See Notes to Editors for further details) Continue reading →
A new study, which involved participants eating pizza well after feeling ‘full’ in order to test what immediate effects this had on the body, finds that our metabolism is surprisingly good at coping with over-indulgence.
Researchers with the Centre for Nutrition, Exercise and Metabolism at the University of Bath compared the effects of normal eating (i.e. ‘eat until you are comfortably full’) with maximal eating (i.e. ‘eat until you cannot manage another bite’).
They found that the young, healthy men (aged 22 – 37) who volunteered for the trial consumed almost twice as much pizza when pushing beyond their usual limits, doubling their calorie intake, yet, remarkably, managed to keep the amount of nutrients in the bloodstream within normal range.
Your Body Mass Index (BMI) can be useful in widely spread studies, but you need to be careful about relying too much on it personally. I posted on it previously and you can read Don’t get hung up on your BMI – Body Mass Index for more info.
Young Arnold Schwarzenegger as Conan the Barbarian. Six foot two inches tall, 257 pounds, BMI 33. Not what most of us would call obese.
The following is from the Tufts Health & Nutrition Letter:
Having obesity increases risk for cardiovascular disease and other metabolic conditions such as type 2 diabetes, but a normal BMI also does not guarantee good heart health. Here are tips based on what we know to date about metabolic health and weight: Continue reading →
A plant-based diet may be key to lowering risk for heart disease. Penn State researchers determined that diets with reduced sulfur amino acids — which occur in protein-rich foods, such as meats, dairy, nuts and soy — were associated with a decreased risk for cardiovascular disease. The team also found that the average American consumes almost two and a half times more sulfur amino acids than the estimated average requirement.
Amino acids are the building blocks of proteins. A subcategory, called sulfur amino acids, including methionine and cysteine, play various roles in metabolism and health.
“For decades it has been understood that diets restricting sulfur amino acids were beneficial for longevity in animals,” said John Richie, a professor of public health sciences at Penn State College of Medicine. “This study provides the first epidemiologic evidence that excessive dietary intake of sulfur amino acids may be related to chronic disease outcomes in humans.” Continue reading →
A new study finds that heart disease may increase your chances of kidney failure.
• In adults followed for a median of 17.5 years, cardiovascular diseases—including heart failure, atrial fibrillation, coronary heart disease, and stroke—were each linked with a higher risk of developing kidney failure.
• Heart failure was associated with the highest risk: adults hospitalized with heart failure had an 11.4-times higher risk of developing kidney failure than individuals without cardiovascular disease
New research indicates that cardiovascular diseases—including heart failure, atrial fibrillation, coronary heart disease, and stroke—are each linked with a higher risk of developing kidney failure. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, highlight the importance of protecting the kidney health of individuals diagnosed with cardiovascular disease.
The heart and the kidneys have a bi-directional relationship, whereby dysfunction in either may compromise the function of the other. Many studies have investigated the risks of kidney disease on heart health, but few have examined the reciprocal relationship.
To investigate, a team led by Kunihiro Matsushita, MD, PhDand Junichi Ishigami, MD, PhD(Johns Hopkins Bloomberg School of Public Health)examined information on 9,047US adults who did not have signs ofheart disease when they enrolled in a community-based study.
“Many physicians probably recognize that patients with cardiovascular disease are at risk of kidney disease progression, but to my knowledge, this is the first study quantifying the contribution of different cardiovascular diseases to the development of kidney failure, said Dr. Matsushita.
People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events compared with those who were given placebo, according to a new meta-analysis from Harvard T.H. Chan School of Public Health and Brigham and Women’s Hospital. Researchers found an association between daily omega-3 supplementation and reduced risk of most CVD outcomes, including heart attack, death from coronary heart disease, and death from CVD, but did not see benefit for stroke. In addition, higher doses of omega-3 fish oil supplements appeared to provide even greater risk reduction.
The study was published online September 30, 2019 in the Journal of the American Heart Association.
“This meta-analysis provides the most up-to-date evidence regarding the effects of omega-3 supplementation on risk of multiple CVD outcomes. We found significant protective effects of daily omega-3 supplementation against most CVD outcome risks and the associations appeared to be in a dose-response manner,” said first author Yang Hu, a postdoctoral fellow in the Department of Nutrition at Harvard Chan School. Continue reading →
I have stated previously in these pages that I while I respect and admire the exercise of running, I have even considered taking it up to get more weight-bearing exercise, I think that on-balance marathons damage the body and should be avoided. Since October is the beginning of marathon season, I wanted to put this out.
Dr. Mercola says, “Several recent studies have indicated that conventional cardio, especially endurance exercises such as marathon running can pose significant risks to your heart. It can result in acute volume overload, inflammation, thickening and stiffening of the heart muscle and arteries, arterial calcification, arrhythmias, and potentially sudden cardiac arrest and stroke—the very things you’re trying to avoid by exercising. ”
The more sugar-sweetened beverages (SSBs) people consumed, the greater their risk of premature death—particularly death from cardiovascular disease, and to a lesser extent from cancer, according to a large long-term study of U.S. men and women. The risk of early death linked with drinking SSBs was more pronounced among women.
The study, led by Harvard T.H. Chan School of Public Health, also found that drinking one artificially sweetened beverage (ASB) per day instead of a sugary one lowered the risk of premature death. But drinking four or more ASBs per day was associated with increased risk of mortality in women.
The study was published in the journal Circulation.
“Our results provide further support to limit intake of SSBs and to replace them with other beverages, preferably water, to improve overall health and longevity,” said Vasanti Malik, research scientist in the Department of Nutrition and lead author of the study. Continue reading →
In my 30’s I was a vegetarian who still ate fish and chicken. In those days I was doing tons of yoga and had no trouble keeping my weight down. I also felt great, of course, I was in my 30’s so why wouldn’t I? I thought this study from Loma Linda University was very enlightening.
A new study out of Loma Linda University Health suggests that eating red and processed meats — even in small amounts — may increase the risk of death from all causes, especially cardiovascular disease.
Saeed Mastour Alshahrani, the lead author of the study and a doctoral student at Loma Linda University School of Public Health, said the research fills an important gap left by previous studies that looked at relatively higher levels of red meat intake and compared them with low intakes. Continue reading →
Whether you are pear-shaped or apple shaped depends a lot on your genes it seems.
A recent study from Uppsala University has found that whether you store your fat around the trunk or in other parts of your body is highly influenced by genetic factors and that this effect is present predominantly in women and to a much lower extent in men. In the study, which is published in Nature Communications, the researchers measured how fat was distributed in nearly 360,000 voluntary participants.
“We know that women and men tend to store fat differently — women have the ability to more easily store fat on the hips and legs, while men tend to accumulate fat around the abdomen to a higher extent,” says lead author Mathias Rask-Andersen, Ph.D. and postdoctoral researcher at the department of Immunology, Genetics and Pathology at Uppsala University. “This has been attributed to the effects of sex hormones such as estrogen. But the molecular mechanisms that control this phenomenon are fairly unknown.”
I am guessing that belly fat is the number one source of concern for people taking up exercise – or continuing it. So many fruitless hours have been spent on ‘ab-work’ like sit-ups and stomach crunches with little sign of success. It turns out that reduction of that ‘spare tire’ is far less complicated than many suppose. Simple, but not obvious.
Summary:According to researchers, interleukin 6 plays a critical role in how exercise helps to reduce body fat. Source: Cell Press.
Some of you may have made a New Year’s resolution to hit the gym to tackle that annoying belly fat. But have you ever wondered how physical activity produces this desired effect? A signaling molecule called interleukin-6 plays a critical role in this process, researchers report December 27 in the journal Cell Metabolism.
This graphical abstract shows that in abdominally obese people, exercise-mediated loss of visceral adipose tissue mass requires IL-6 receptor signaling. NeuroscienceNews.com image is credited to Wedell-Neergaard, Lehrskov, and Christensen, et al. / Cell Metabolism.
As expected, a 12-week intervention consisting of bicycle exercise decreased visceral abdominal fat in obese adults. But remarkably, this effect was abolished in participants who were also treated with tocilizumab, a drug that blocks interleukin-6 signaling and is currently approved for the treatment of rheumatoid arthritis. Moreover, tocilizumab treatment increased cholesterol levels regardless of physical activity.
“The take home for the general audience is ‘do exercise,’” says first author Anne-Sophie Wedell-Neergaard of the University of Copenhagen. “We all know that exercise promotes better health, and now we also know that regular exercise training reduces abdominal fat mass and thereby potentially also the risk of developing cardio-metabolic diseases.”
Researchers retrospectively studied 122,007 patients who underwent exercise treadmill testing at Cleveland Clinic between Jan. 1, 1991, and Dec. 31, 2014, to measure all-cause mortality relating to the benefits of exercise and fitness. The paper was published in the Journal of the American Medical Association Network Open.
The study found that increased cardiorespiratory fitness was directly associated with reduced long-term mortality, with no limit on the positive effects of aerobic fitness. Extreme aerobic fitness was associated with the greatest benefit, particularly in older patients (70 and older) and in those with hypertension.
“Aerobic fitness is something that most patients can control. And we found in our study there is no limit to how much exercise is too much,” said Wael Jaber, M.D., Cleveland Clinic cardiologist and senior author of the study. “Everyone should be encouraged to achieve and maintain high fitness levels.”Continue reading →
A comprehensive worldwide study of alcohol use and its impact on health concludes that the safest level of consumption is zero. The Global Burden of Disease Study 2016 has calculated levels of alcohol use and its effects on health during 1990–2016 in 195 countries.
The research, which now features in the journal The Lancet, notes that in 2016, alcohol use was responsible for almost 3 million deaths globally.
Alcohol use was the main cause of death for people aged 15–49 that year, accounting for 12 percent of deaths in men of that age.
“Our findings,” says senior study author Dr. Emmanuela Gakidou, who currently works at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington in Seattle, “are consistent with other recent research, which found clear and convincing correlations between drinking and premature death, cancer, and cardiovascular problems.”Continue reading →