A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer’s disease.
Dr. Mallar Chakravarty, a computational neuroscientist at the Douglas Mental Health University Institute, and his colleagues from the University of Toronto and the Center for Addiction and Mental Health, designed an algorithm that learns signatures from magnetic resonance imaging (MRI), genetics, and clinical data. This specific algorithm can help predict whether an individual’s cognitive faculties are likely to deteriorate towards Alzheimer’s in the next five years.
“At the moment, there are limited ways to treat Alzheimer’s and the best evidence we have is for prevention. Our AI methodology could have significant implications as a ‘doctor’s assistant’ that would help stream people onto the right pathway for treatment. For example, one could even initiate lifestyle changes that may delay the beginning stages of Alzheimer’s or even prevent it altogether,” says Chakravarty, an Assistant Professor in McGill University’s Department of Psychiatry. Continue reading
I don’t know if these really will increase your brain power, but I don’t see any harm in letting you know about them.
Please let me know if you have any experience with these.To my knowledge they are all excellent foods nutritionally.
Scientists at the Medical University of South Carolina (MUSC) have uncovered mechanisms by which high levels of a hormone called FGF23 can reduce brain health.
In results published in the journal PLoS ONE, high levels of fibroblast growth factor 23 (FGF23) were associated with structural changes in the brain’s frontal lobes. High FGF23 levels are thought to lead to the vascular calcification seen in patients with chronic kidney disease. The study showed that such a process may also affect the brain in patients without chronic kidney disease but with elevated cardiovascular risk factors, according to Leonardo Bonilha, M.D., Ph.D., associate professor of neurology in the MUSC Department of Medicine and director of the study.
“We found that there is a relationship between high levels of FGF23 and a form of structural compromise in the brain,” said Bonilha.
FGF23 is produced in the bone. Normally, FGF23 works in the kidneys and the gut to regulate levels of calcium and phosphate in the body. It is thought to be increased in people who eat a diet high in phosphates, which are often found in foods with preservatives. In people with chronic kidney disease or in those who consume a diet high in phosphates, can be a calcification of their arteries, which can cause heart attack or stroke. FGF23 may be the reason. Continue reading
They say you can’t teach old dogs new tricks, but new research shows you can teach an old rat new sounds, even if the lesson doesn’t stick very long.
For the record I wrote a post on that damaging cliche about teaching old dogs new tricks. You can read it here – Of cats and dogs and cliches ….
Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University examined the effects of aging on neuroplasticity in the primary auditory cortex, the part of the brain that processes auditory information. Neuroplasticity refers to the brain’s ability to modify its connections and function in response to environmental demands, an important process in learning.
Plasticity in the young brain is very strong as we learn to map our surroundings using the senses. NeuroscienceNews.com image is in the public domain.
Plasticity in the young brain is very strong as we learn to map our surroundings using the senses. As we grow older, plasticity decreases to stabilize what we have already learned. This stabilization is partly controlled by a neurotransmitter called gamma-Aminobutyric acid (GABA), which inhibits neuronal activity. This role of GABA was discovered by K.A.C. Elliot and Ernst Florey at The Neuro in 1956. Continue reading
With three cases of Alzheimer’s Disease or dementia in my family I have serious interest in all variations of cognitive impairment. Hence, this latest work from Washington University School of Medicine.
It may be possible in the future to screen patients for Alzheimer’s disease using an eye exam.
Using technology similar to what is found in many eye doctors’ offices, researchers at Washington University School of Medicine in St. Louis have detected evidence suggesting Alzheimer’s in older patients who had no symptoms of the disease.
Their study, involving 30 patients, is published Aug. 23 in the journal JAMA Ophthalmology. Continue reading
One of my favorite (and most popular) posts is Exercise, Aging and the Brain. I wrote it in 2011 and more than 11,000 people have read it. Because of Alzheimer’s and dementia residing in my immediate family, I am very interested in the brain and anything that affects it. So, this study from Medical Express hit me right where I live.
In the largest known brain imaging study, scientists from Amen Clinics (Costa Mesa, CA), Google, John’s Hopkins University, University of California, Los Angeles and the University of California, San Francisco evaluated 62,454 brain SPECT (single photon emission computed tomography) scans of more than 30,000 individuals from 9 months old to 105 years of age to investigate factors that accelerate brain aging. SPECT tomography) evaluates regional cerebral blood flow in the brain that is reduced in various disorders.
Lead author, psychiatrist Daniel G. Amen, MD, founder of Amen Clinics, commented, “Based on one of the largest brain imaging studies ever done, we can now track common disorders and behaviors that prematurely age the brain. Better treatment of these disorders can slow or even halt the process of brain aging. The cannabis abuse finding was especially important, as our culture is starting to see marijuana as an innocuous substance. This study should give us pause about it.” Continue reading
I am a big supporter of Positivity. You can check out my Page, which includes a super graphic video, Positive psychology – What’s it all about?
The following study was written up by Anne Trafton of the MIT News office.
Many patients with neuropsychiatric disorders such as anxiety or depression experience negative moods that lead them to focus on the possible downside of a given situation more than the potential benefit.
MIT neuroscientists have found that stimulating part of the striatum can induce feelings of pessimism. (Anatomography/Life Science Databases)
MIT neuroscientists have now pinpointed a brain region that can generate this type of pessimistic mood. In tests in animals, they showed that stimulating this region, known as the caudate nucleus, induced animals to make more negative decisions: They gave far more weight to the anticipated drawback of a situation than its benefit, compared to when the region was not stimulated. This pessimistic decision-making could continue through the day after the original stimulation. Continue reading
I confess, I am blown away by the brain. I took a course in it from The Great Courses and have published a number of posts on it. The direct connection between physical exercise and the brain never ceases to amaze me. You can check out my Page – Important facts about your brain – (and exercise benefits) to read more.
Eat less; move more; live longer. It’s never too late to start.
Exercising regularly throughout life is the best way to keep your heart healthy. But starting to exercise even in late middle age may lessen the risk of heart failure, according to a report in the May 15 issue of Circulation. Heart failure, a gradual decline in the heart’s ability to pump enough blood to meet the body’s needs, affects about 6.5 million people in the United States.
The study involved more than 11,000 people who were part of a long-running project begun in the late 1980s, the Atherosclerosis Risk in Communities Study. Every six years, participants got medical testing and filled out questionnaires about their physical activity.
People who followed federal recommendations for physical activity (see How much physical activity do you need?) for the first 12 years of the study had the lowest risk of heart failure—31% lower than people who didn’t exercise at all. But people who increased their physical activity levels starting around age 60 over a period of just six years lowered their risk by 12%.
I have written repeatedly about the benefits of exercise on the brain’s health. Now, it seems that you can combine exercise with cognitive training for positive results.
Researchers at York University’s Faculty of Health found that just 30 minutes of visually-guided movements per week can slow and even reverse the progress of dementia. Those in the early stages of dementia who were exposed to 30 minutes a week to a game which used rules to make visually-guided movements, were able to slow down the progress of dementia and for some, even reverse their cognitive function to healthy status.
Previous approaches have used cognitive training alone or aerobic exercise training alone. This study published in Dementia and Geriatric Disorders, is the first to investigate the impact of combining both types of approaches on cognitive function in elderly people with various degrees of cognitive defects.
“We found cognitive-motor integration training slows down the progress of dementia, and for those just showing symptoms of dementia, this training can actually revert them back to healthy status, stabilizing them functionally,” says lead researcher, Lauren Sergio, professor in the School of Kinesiology and Health Science and Centre for Vision Research at York University. Continue reading
I thought this had some good information in it. I hope you are able to read the explanations.
As I have said numerous times here, I love it when fresh news meets my bias. The one I am thinking about is how physical exercise benefits brain function. You can check out my post – Can exercise help me to learn? And, don’t forget my Page – Important facts about your brain – and exercise benefits.
If you want to learn to walk a tightrope, it’s a good idea to go for a short run after each practice session. That’s because a recent study in NeuroImage demonstrates that exercise performed immediately after practicing a new motor skill improves its long-term retention. More specifically, the research shows, for the first time, that as little as a single fifteen-minute bout of cardiovascular exercise increases brain connectivity and efficiency. It’s a discovery that could, in principle, accelerate recovery of motor skills in patients who have suffered a stroke or who face mobility problems following an injury. Continue reading
This time it’s personal. A hundred years ago, it seems (actually it was 1977), I worked for Reuters News Service. I had the good fortune, I thought, of being sent to London to experience the international news desk. That turned out to be a wonderful educational as well as professional experience. However, part of my deal was that since I was the Yank who was only there for a year, they used me to fill every staffing vacancy that came up. As a result I often worked two or three different shifts in a week. I have to tell you that I have never felt so discombobulated in my life. I would wake up and not know if it was morning or night. All my body rhythms got fried. So, I really related to the following study.
Researchers report metabolic disruptions often seen in shift workers are not influenced by the brain’s circadian rhythm, but by peripheral oscillators in the liver, gut and pancreas. Source: Washington State University.
Working night shifts or other nonstandard work schedules increases your risk of becoming obese and developing diabetes and other metabolic disorders, which ultimately also raises your risk of heart disease, stroke and cancer.
Exactly why this happens has been unclear, but a new study conducted at Washington State University (WSU) has brought scientists closer to finding the answer. Continue reading
In view of the current heat wave, I thought this study would be of particular interest.
Researchers report on how specific neurons can process sensory information about temperature and facilitate a change in behavior to adapt to the climate.
Do you pause what you’re doing to put on a sweater because you feel chilly? Do you click the thermostat up a few degrees on a winter day? What about keeping a fan on your desk, or ducking into an air-conditioned room to beat the heat?
If so (and, let’s face it, everyone has), then you’ve used sensory information about your environment — the temperature — to alter your behavior.
Haesemeyer said he plans to work on getting a more detailed picture of the neural circuit in the hind brain that translates heat information into behavior. NeuroscienceNews.com image is in the public domain.
But exactly how the brain processes that information has largely remained a mystery. To shed light on that, a team of researchers led by Martin Haesemeyer, a research associate in the labs of Florian Engert, professor of molecular and cellular biology, and Alexander Schier, the Leo Erikson Life Sciences Professor of Molecular and Cellular Biology, turned to an unlikely subject: zebrafish. Continue reading
A new study reports high sugar and fat based diets that lead to obesity, coupled with the normal aging process, may increase the risk of Alzheimer’s disease. By my reckoning that means the older we get the more we need to pay attention to what we are eating and the amount we are exercising. Eat less; move more; live longer. For heaven’s sake, don’t wait till you are a senior to get on the exercise and good eating regime. Clearly, the earlier you start, the better of you are.
A new study suggests that when a high-fat, high-sugar diet that leads to obesity is paired with normal aging, it may contribute to the development of Alzheimer’s disease. In addition, researchers discovered that certain areas of the brain respond differently to risk factors associated with Alzheimer’s. The study is published in Physiological Reports.
Alzheimer’s disease, the most common form of dementia, is a progressive brain disorder that leads to loss of cognitive skills and memory and causes significant changes in behavior. Aging is a significant risk factor for Alzheimer’s. Previous studies suggest that diet-related obesity is also associated with development of the disease. Continue reading
More good news on exercise this morning. Writing in the British Psychological Society Research Digest, Emma Young reports positive news on the move more section of our eat less; move more; live longer mantra.
Aerobic exercise – any activity that gets your heart pumping harder – improves mood, anxiety and memory. It can help people with major depressive disorder, bipolar disorder and anxiety disorder. Now there’s evidence, from a randomized controlled trial published in Frontiers in Psychiatry, that a program of regular aerobic exercise also reduces psychopathology in people diagnosed with schizophrenia. And it seems to have a particular impact on so-called “negative” symptoms, such as apathy and loss of emotional feeling, which are not improved by standard drug treatments.
“[W]hile antipsychotics [drug treatments] are essential in treating schizophrenia, interventions other than antipsychotic treatment…may be needed to achieve better outcomes,” write the authors of the new study, led by Peng-Wei Wang at Kaohsiung Medical University Hospital in Taiwan. Continue reading