Tag Archives: exercise and brain health

Exercise May Help Slow Memory Loss for People Living With Alzheimer’s Dementia

Exercise may reduce decline in global cognition in older adults with mild-to-moderate AD dementia. Aerobic exercise did not show superior cognitive effects to stretching in our pilot trial, possibly due to the lack of power. ASU Edson College of Nursing and Health Innovation Professor Fang Yu led a pilot randomized control trial that included 96 older adults living with mild to moderate Alzheimer’s dementia.

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Participants were randomized to either a cycling (stationary bike) or stretching intervention for six months. Using the Alzheimer’s Disease Assessment Scale-Cognition (ADAS-Cog) to assess cognition, the results of the trial were substantial.

The six-month change in ADAS-Cog was 1.0±4.6 (cycling) and 0.1±4.1 (stretching), which were both significantly less than the expected 3.2±6.3-point increase observed naturally with disease progression.

“Our primary finding indicates that a six-month aerobic exercise intervention significantly reduced cognitive decline in comparison to the natural course of changes for Alzheimer’s dementia. However, we didn’t find a superior effect of aerobic exercise to stretching, which is likely due to the pilot nature of our trial. We don’t have the statistical power to detect between-group differences, there was substantial social interaction effect in the stretching group, and many stretching participants did aerobic exercise on their own.” Yu said.

The findings are described in a recently published article, Cognitive Effects of Aerobic Exercise in Alzheimer’s Disease: A Pilot Randomized Controlled Trial, in the Journal of Alzheimer’s Disease.

Yu says their results are encouraging and support the clinical relevance of promoting aerobic exercise in individuals with Alzheimer’s dementia to maintain cognition.

“Aerobic exercise has a low profile of adverse events in older adults with Alzheimer’s dementia as demonstrated by our trial,” said Yu. “Regardless of its effect on cognition, the current collective evidence on its benefits supports the use of aerobic exercise as an additional therapy for Alzheimer’s disease.”

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Blink! The Link between Aerobic Fitness and Cognition

Although exercise is known to enhance cognitive function and improve mental health, the neurological mechanisms of this link are unknown. Now, researchers from Japan have found evidence of the missing link between aerobic fitness and cognitive function.


In a study published in Medicine & Science in Sports & Exercise, researchers from the University of Tsukuba revealed that spontaneous eye blink rate (sEBR), which reflects activity of the dopamine system, could be used to understand the connection between cognitive function and aerobic fitness.

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The dopaminergic system is known to be involved in physical activity and exercise, and previous researchers have proposed that exercise-induced changes in cognitive function might be mediated by activity in the dopaminergic system. However, a marker of activity in this system was needed to test this hypothesis, something the researchers at the University of Tsukuba aimed to address.

“The dopaminergic system is associated with both executive function and motivated behavior, including physical activity,” says first author of the study Ryuta Kuwamizu. “We used sEBR as a non-invasive measure of dopaminergic system function to test whether it could be the missing link between aerobic fitness and cognitive function.”

To do this, the researchers asked healthy participants to undergo a measure of sEBR, a test of cognitive function, and an aerobic fitness test. They also measured brain activity during the cognitive task using functional near-infrared spectroscopy.

“As expected, we found significant correlations between aerobic fitness, cognitive function, and sEBR,” explains Professor Hideaki Soya, senior author. “When we examined these relationships further, we found that the connection between higher aerobic fitness and enhanced cognitive function was mediated in part by dopaminergic regulation.”

Furthermore, activity in the left dorsolateral prefrontal cortex (l-DLPFC) during the cognitive task was the same or lower in participants with higher sEBR compared with lower sEBR, even though those with higher sEBR appeared to have greater executive function, and thus higher neural efficiency.

“Although previous studies have indicated that aerobic fitness and cognitive function are correlated, this is the first to provide a neuromodulatory basis for this connection in humans. Our data indicate that dopamine has an essential role in linking aerobic fitness and cognition,” says first author Kuwamizu.

Given that neural efficiency in the l-DLPFC is a known characteristic of the dopaminergic system that has been observed in individuals with higher fitness and executive function, it is possible that neural efficiency in this region partially mediates the association between aerobic fitness and executive function. Furthermore, physical inactivity may be related to dopaminergic dysfunction. This information provides new directions for research regarding how fitness affects the brain, which may lead to improved exercise regimens. For instance, exercise that specifically focuses on improving dopaminergic function may particularly boost motivation, mood, and mental function.

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Physical exercise and dementia

Of all the lifestyle changes that have been studied, taking regular physical exercise appears to be one of the best things that you can do to reduce your risk of getting dementia according to the Alzheimer’s Society.

Several studies looking at the effect of aerobic exercise (exercise that increases your heart rate) in middle-aged or older adults have reported improvements in thinking and memory, and reduced rates of dementia.

Exercising in mid-life

Prospective studies follow the health and behavior of a group of people over time. Several prospective studies have looked at middle-aged people and the effects of physical exercise on their thinking and memory in later life. Combining the results of 11 studies shows that regular exercise can significantly reduce the risk of developing dementia by about 30 per cent. For Alzheimer’s disease specifically, the risk was reduced by 45 per cent.

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Sport and memory go hand in hand – Study

Eat less; move more; live longer has been the mantra of this blog for years. It may be that think better can be added to it.

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If sport is good for the body, it also seems to be good for the brain. By evaluating memory performance following a sport session, neuroscientists from the University of Geneva (UNIGE) demonstrate that an intensive physical exercise session as short as 15 minutes on a bicycle improves memory, including the acquisition of new motor skills. How? Through the action of endocanabinoids, molecules known to increase synaptic plasticity. This study, to be read in the journal Scientific Reports, highlights the virtues of sport for both health and education. School programmes and strategies aimed at reducing the effects of neurodegeneration on memory could indeed benefit from it.

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Regular physical activity to enhance cognition in children who need it most

A common school-age stereotype is that smart kids are unathletic. However, as a recent study lead by Associate Professor Keita Kamijo at the University of Tsukuba and Assistant Professor Toru Ishihara at Kobe University shows that physical activity is linked to better cognitive ability, which is in turn related to academic performance in school.

Understanding the effects of physical activity on cognition has been difficult for several reasons. “Previous studies looked at the issue too broadly,” explains Professor Kamijo, “When we broke down the data, we were able to see that physical activity helps children the most if they start out with poor executive function.”

Relationship between baseline performance and pre–post changes in cognitive performance, illustrating the group × baseline performance interaction.

Executive functions refer to three types of cognitive skills. The first is the ability to suppress impulses and inhibit reflex-like behaviors or habits. To assess this ability, children were asked to indicate the color in which words like “red” and “blue” were displayed on a computer screen. This is easy when the words and colors match (“red” displayed in red font), but often requires inhibition of a reflex response when they don’t (“red” displayed in blue font). The second skill is the ability to hold information in working memory and process it. This was evaluated by testing how well children could remember strings of letters that vary in length. The third cognitive skill is mental flexibility. This was measured by asking children to frequently switch the rules for categorizing colored circles and squares from shape-based to color-based.

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Aerobics a smart workout for your brain at any age

It’s never too late to lace up some sneakers and work up a sweat for brain health, according to a study published in the May 13, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study suggests older adults, even couch potatoes, may perform better on certain thinking and memory tests after just six months of aerobic exercise.

“As we all find out eventually, we lose a bit mentally and physically as we age. But even if you start an exercise program later in life, the benefit to your brain may be immense,” said study author Marc J. Poulin, Ph.D., D.Phil., from the Cumming School of Medicine at the University of Calgary in Alberta, Canada. “Sure, aerobic exercise gets blood moving through your body. As our study found, it may also get blood moving to your brain, particularly in areas responsible for verbal fluency and executive functions. Our finding may be important, especially for older adults at risk for Alzheimer’s and other dementias and brain disease.”

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Brain benefits of exercise can be gained with a single protein

A little-studied liver protein may be responsible for the well-known benefits of exercise on the aging brain, according to a new study in mice by scientists in the UC San Francisco Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research. The findings could lead to new therapies to confer the neuroprotective effects of physical activity on people who are unable to exercise due to physical limitations.

Exercise is one of the best-studied and most powerful ways of protecting the brain from age-related cognitive decline and has been shown to improve cognition in individuals at risk of neurodegenerative disease such as Alzheimer’s disease and frontotemporal dementia — even those with rare gene variants that inevitably lead to dementia.

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Walking: Key To Staying Active and Independent

Did you get your 10,000 steps today? Many people have adopted this daily walking goal to obtain the recommended amount of physical activity. The 10,000-steps-a-day number comes from the Japanese brand name of a pedometer manufactured in the 1960s, the “10,000 steps meter.” In the Fitbit era, counting daily steps remains appealing to many people as a source of motivation.

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In the US, adults are urged to get the equivalent of 150 minutes per week of moderate intensity exercise. Walking is a popular way to meet those recommendations, particularly in older adults or people who are relatively physically inactive.

Although 10,000 steps is a worthy challenge, aiming for more exercise than you normally get—unless you are one of the few who regularly trains for marathons or triathlons—comes with benefits. Any amount or type of physical activity adds to your daily goal. Regularly taking the stairs instead of the elevator, or parking farther away from your destination, can make a measurable improvement in your health.

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Men: Exercise Can Do a Lot More for You than Build Muscle

Men face some serious health risks. The two most serious ones, heart disease and cancer, account for nearly half of deaths among American men. Unintentional injuries like falls are the third most common cause of death for men. Lung disease and stroke round out the top five, according to Blue Cross Blue Shield of Illinois.

The good news: Along with other healthy lifestyle choices, the right kinds of physical activity can help prevent these and other health threats.

Ward Off Heart Disease: Get Moving

Aerobic exercise such as walking, swimming, running or biking strengthens your heart and lowers your blood pressure. Aim for at least 30 minutes of moderate intensity aerobic activity five days per week. You don’t have to do it all at once. Three 10-minute walks can be as effective as one 30-minute walk at lowering blood pressure.

You can even get in activity during the work day. Break up the long hours at a desk by getting up and moving around at least once an hour. Just taking a short two-minute stroll can help to keep blood sugar levels stable. When you can, stand up to take breaks from sitting.

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Neighborhood features affect cognitive function in seniors

As a senior citizen who has had family members suffer from dementia and Alzheimer’s Disease, I want to know everything I can about aging and cognition, so this study from Florida Atlantic University piqued my interest.

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The neighborhood environment may positively or negatively influence one’s ability to maintain cognitive function with age. Since older adults spend less time outside, the neighborhood environment increases in importance with age. Studies suggest physical aspects of the neighborhood such as the availability of sidewalks and parks, and more social and walking destinations, may be associated with better cognitive functioning. Beneficial neighborhood environments can provide spaces for exercise, mental stimulation, socializing and reducing stress. To date, few studies have examined how the neighborhood’s physical environment relates to cognition in older adults. Continue reading

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I am 80 years old today!?

Holy crap! I am an octogenarian! I can’t believe it. I don’t feel that old. In fact, having been retired for 20 years now, I can honestly say, I feel better and healthier now than when I was working and in my ’50’s. I rode my bike 25 miles yesterday in Chicago’s balmy 30 degree weather and I plan to do the same this morning. Lucky me!

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This is my birthday picture from a few years back. It’s the only one I have that’s decorated. Also, my pup is in it, too.

This is from my birthday blog post last year:

One of the main reasons I feel like I have things so together is this blog. I started writing it in March of 2010 with a partner who has since left for other pursuits. From the beginning, I discovered a focus. At first it was simply trying to keep my weight down. I learned portion control and serving size. This Italian guy was surprised to learn that a “serving” of pasta was not a 10 inch plate heaped with spaghetti noodles smothered in tomato sauce. No, a 200 calorie serving of pasta is about the size of a baseball. Incredibly, that was a revelation to me. I put the information to use. I began to reduce my portions accordingly. I am not going to recount all the lessons I learned in the past nearly 10 years, but if you want to get control of your own weight, check out my Page – How to Lose Weight – and Keep it Off. Continue reading

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Your brain needs physical exercise – Scientific American

I have written repeatedly about the brain benefits from physical exercise. Asregular readers know, I have a visceral interest in this having lost three family members to dementia. My mother suffered from dementia. Her sister died of Alzheimer’s Disease and my father’s father also was cognitively challenged. That goes back to the mid 1940’s when far less was understood about cognition in general.

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Scientific American illustration by Tami Tolpa

Now comes the latest issue of Scientific American with fresh insights into the brain/exercise situation:

People often consider walking and running to be activities that the body is able to perform on autopilot. But research carried out over the past decade by us and others would indicate that this folk wisdom is wrong. Instead exercise seems to be as much a cognitive activity as a physical one….

But simply exercising more may not realize the full potential of physical activity for keeping brain decline at bay. Indeed, our model suggests that even people who already get a lot of aerobic activity may want to rethink their routines. It is possible that we might not always exercise in ways that take full advantage of our evolved mechanisms for sustaining brain performance….

… we have developed a game designed to specifically challenge aspects of cognition that tend to decline with age and that are probably needed during foraging. In the game, players spatially navigate and complete attention and memory tasks while cycling at a moderate aerobic intensity level.

Tony

 

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Muscle loss linked to cognitive decline

I have written repeatedly about the benefits of exercise on both the body and brain. It turns out that there seems to be a link between loss of muscle mass, sarcopenia, and cognitive decline.

Sarcopenia, the loss of muscle mass, tends to happen naturally with age. So, in older people with sarcopenia, excess body fat may not be readily visible. But hidden fat, paired with muscle mass loss later in life, could predict Alzheimer’s risk, researchers warn.

A recent study — the results of which have been published in the journal Clinical Interventions in Aging — has found that sarcopenia and obesity (independently, but especially when occurring together) can heighten the risk of cognitive function impairments later in life.

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The research was conducted by scientists at the Comprehensive Center for Brain Health at the Charles E. Schmidt College of Medicine of Florida Atlantic University in Boca Raton.

“Sarcopenia,” explains senior study author Dr. James Galvin, “has been linked to global cognitive impairment and dysfunction in specific cognitive skills including memory, speed, and executive functions.” Continue reading

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Exercise and heart-healthy diet may slow memory problems developing

Cognitive impairment without dementia (CIND), or mild cognitive impairment, is a condition that affects your memory and may put you at risk for Alzheimer’s disease and dementia. According to the U.S. National Library for Medicine, signs of mild cognitive impairment may include frequently losing things, forgetting to go to events and appointments, and having more trouble coming up with words than other people of your age.

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My go-to exercise is biking. My dog comes along when the weather is willing. At 79, everything seems to be working …

Some experts believe that risk factors for heart disease also are risk factors for dementia and late-life cognitive decline and dementia. Recently, researchers examined two potential ways to slow the development of CIND based on what we know about preventing heart disease. They published the results of their study in the Journal of the American Geriatrics Society. Continue reading

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Improved fitness can mean living longer without dementia – Study

“It is important to say that it is never too late to begin exercising. The average participant in our study was around 60 years old at baseline, and improvement in cardio-respiratory fitness was strongly linked to lower dementia risk. Those who had poor fitness in the 1980s but improved it within the next decade could expect to live two years longer without dementia,” says Atefe Tari of the Cardiac Exercise Research Group (CERG) at the Norwegian University of Science and Technology (NTNU).

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Tari is lead author of a new study that was recently published in Lancet Public Health, a highly ranked journal in the prestigious Lancet family.

“Persistently low fitness is an independent risk factor for dementia and death due to dementia,” the authors concluded. Continue reading

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Aging folks worried about dementia risk

Nearly half of Americans in their 50s and early 60s think they’re likely to develop dementia as they grow older, but only 5% of them have actually talked with a doctor about what they could do to reduce their risk, a new study finds. 

Meanwhile, a third or more say they’re trying to stave off dementia by taking supplements or doing crossword puzzles – despite the lack of proof that such tactics work. 

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The new findings suggest a need for better counseling for middle-aged Americans about the steps they can take to keep their brains healthy as they age.

Meanwhile, pharmaceutical companies continue to work on potential dementia-preventing medications. But an over-estimation of future dementia risk by individuals may lead to costly over-use of such products, the researchers warn.

The new results appear in a research letter in the new edition of JAMA Neurology, and a presentation at the Gerontological Society of America’s annual meeting.

Both are by members of a team from the University of Michigan’s Institute for Healthcare Policy and Innovation who analyzed data from a nationally representative poll of 1,019 adults between the ages of 50 and 64.

Donovan Maust, M.D., M.S., a geriatric psychiatrist specializing in dementia-related care and lead author of the JAMA Neurology letter, notes that even among the oldest Americans, the risk of dementia is lower than one in three people over age 85.

Risk starts rising around age 65, and is higher among people of Latino or African-American heritage. Continue reading

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