Tag Archives: Alzheimer’s Disease

How well we sleep may forecast when Alzheimer’s begins

What would you do if you knew how long you had until Alzheimer’s disease set in? Don’t despair. New research from the University of California, Berkeley, suggests one defense against this virulent form of dementia — for which no treatment currently exists — is deep, restorative sleep, and plenty of it.

UC Berkeley neuroscientists Matthew Walker and Joseph Winer have found a way to estimate, with some degree of accuracy, a time frame for when Alzheimer’s is most likely to strike in a person’s lifetime.

“We have found that the sleep you’re having right now is almost like a crystal ball telling you when and how fast Alzheimer’s pathology will develop in your brain,” said Walker, a UC Berkeley professor of psychology and neuroscience and senior author of the paper published, Sept. 3, in the journal Current Biology.

2 Comments

Filed under Uncategorized

Insights into Newly Characterized Form of Dementia

Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between sub-types of dementia inducing brain disease.

Photo by meo on Pexels.com

“For the first time we created criteria that could differentiate between frontotemporal dementia (FTD) and a common Alzheimer’s ‘mimic’ called LATE disease,” said Dr. Peter Nelson of the Sanders-Brown Center on Aging at the University of Kentucky. He says they validated the criteria rigorously. The study was recently published in BRAIN: A Journal of Neurology. The first author of the paper was John L. Robinson from the University of Pennsylvania and the corresponding author was Nelson.

4 Comments

Filed under aging brain, Alzheimer's disease, Alzheimer's risk, brain function, brain research, dementia, Healthy brain

Coming soon – A simple blood test for diagnosing Alzheimer’s disease

By now I think everybody reading this blog knows about my family’s connection to Alzheimer’s and dementia. So,it should come as no surprise that I am thrilled to pass on this latest info from the Alzheimer’s Prevention Registry.

Photo by David Cassolato on Pexels.com

A promising new blood test for Alzheimer’s disease is now on the horizon.  The newly reported test proved to be just as reliable as more invasive and costly tests at detecting Alzheimer’s and may even be able to detect the disease as long as 20 years prior to symptoms.  This is an exciting new development that could make detecting the disease much easier and speed up enrollment in clinical trials.

Leave a comment

Filed under Uncategorized

New blood test shows great promise in the diagnosis of Alzheimer’s disease

A new blood test demonstrated remarkable promise in discriminating between persons with and without Alzheimer’s disease and in persons at known genetic risk may be able to detect the disease as early as 20 years before the onset of cognitive impairment, according to a large international study published in the Journal of the American Medical Association (JAMA) and simultaneously presented at the Alzheimer’s Association International Conference.

photo of head bust print artwork

Photo by meo on Pexels.com

For many years, the diagnosis of Alzheimer’s has been based on the characterization of amyloid plaques and tau tangles in the brain, typically after a person dies. An inexpensive and widely available blood test for the presence of plaques and tangles would have a profound impact on Alzheimer’s research and care. According to the new study, measurements of phospho-tau217 (p-tau217), one of the tau proteins found in tangles, could provide a relatively sensitive and accurate indicator of both plaques and tangles — corresponding to the diagnosis of Alzheimer’s — in living people. Continue reading

Leave a comment

Filed under Alzheimer's disease, Alzheimer's risk, Uncategorized

Memory loss reversed or abated in those with cognitive decline

Cognitive decline is a major concern of the aging population. Already, Alzheimer’s disease affects approximately 5.4 million Americans and 30 million people globally. Without effective prevention and treatment, the prospects for the future are bleak. By 2050, it is estimated that 160 million people globally will have the disease, including 13 million Americans, leading to potential bankruptcy of the Medicare system. Unlike several other chronic illnesses, Alzheimer’s disease is on the rise–recent estimates suggest that Alzheimer’s disease has become the third leading cause of death in the United States behind cardiovascular disease and cancer. Since its first description over 100 years ago, Alzheimer’s disease has been without effective treatment.

While researchers continue to seek out a cure, it is becoming clear that there are effective treatment options. More and more research supports the conclusion that Alzheimer’s disease is not a disease of only Beta Amyloid plaques and Tao tangles but a complex and systemic disease. In this study of patients with varying levels of cognitive decline, it is demonstrated how a precision and personalized approach results in either stabilization or improvement in memory.

239082_web.jpg

Affirmativ Health sought to determine whether a comprehensive and personalized program, designed to mitigate risk factors of Alzheimer’s disease could improve cognitive and metabolic function in individuals experiencing cognitive decline. Findings provided evidence that this approach can improve risk factor scores and stabilize cognitive function.

Continue reading

1 Comment

Filed under aging brain, Alzheimer's disease, Alzheimer's risk, brain, brain function, brain health

Scientists study the link between the gut and Alzheimer’s disease

Do you know that feeling you get in your gut? It turns out your gut may really be trying to tell you something.  Our microbiome – the 100 trillion bacteria and organisms living in our gut – appears to have a profound influence on our health and risk of disease. And early scientific studies show there may be a link between the microbiome and the brain that could impact the risk of Alzheimer’s and other brain diseases.

The microbiome is a collection of bacteria, viruses and fungi that live mostly in our intestinal system. They play an important role in digestion and the production of certain vitamins, and they support our immune system. Researchers around the world study the gut microbiome, especially those bacteria unique to individuals, to learn more about their influence on our overall health.

5 Comments

Filed under aging brain, Alzheimer's disease, Alzheimer's risk, brain, brain function, gut bacteria, gut health, gut microbes

“Love hormone” oxytocin could be used to treat cognitive disorders like Alzheimer’s

Alzheimer’s disease is a progressive disorder in which the nerve cells (neurons) in a person’s brain and the connections among them degenerate slowly, causing severe memory loss, intellectual deficiencies, and deterioration in motor skills and communication. One of the main causes of Alzheimer’s is the accumulation of a protein called amyloid β (Aβ) in clusters around neurons in the brain, which hampers their activity and triggers their degeneration.

Tokyo University of Science illustration

Studies in animal models have found that increasing the aggregation of Aβ in the hippocampus–the brain’s main learning and memory center–causes a decline in the signal transmission potential of the neurons therein. This degeneration affects a specific trait of the neurons, called “synaptic plasticity,” which is the ability of synapses (the site of signal exchange between neurons) to adapt to an increase or decrease in signaling activity over time. Synaptic plasticity is crucial to the development of learning and cognitive functions in the hippocampus. Thus, Aβ and its role in causing cognitive memory and deficits have been the focus of most research aimed at finding treatments for Alzheimer’s.

Leave a comment

Filed under Alzheimer's disease, Alzheimer's risk, cognition, cognitive decline, cognitive impairment, oxytocin

Repetitive negative thinking linked to dementia risk

In the study of people aged over 55, published in Alzheimer’s & Dementia, researchers found ‘repetitive negative thinking’ (RNT) is linked to subsequent cognitive decline as well as the deposition of harmful brain proteins linked to Alzheimer’s.

The researchers say RNT should now be further investigated as a potential risk factor for dementia, and psychological tools, such as mindfulness or meditation, should be studied to see if these could reduce dementia risk.

Lead author Dr Natalie Marchant (UCL Psychiatry) said: “Depression and anxiety in mid-life and old age are already known to be risk factors for dementia. Here, we found that certain thinking patterns implicated in depression and anxiety could be an underlying reason why people with those disorders are more likely to develop dementia.

1 Comment

Filed under Uncategorized

Can aspirin reduce dementia risks? – Study

As the old adage goes, an aspirin a day keeps the doctor away. However, new research shows that an aspirin a day will not keep dementia away.

The ASPREE study, Aspirin in Reducing Events in Elderly, evaluated the use of daily, low-dose aspirin in delaying cognitive decline for healthy older adults. Unfortunately, the study did not find that aspirin had any benefit on reducing memory and thinking problems.

Photo by Anna Shvets on Pexels.com

“Aspirin is a commonly used drug known to reduce inflammation.,” explained Joanne Ryan, PhD, who collaborated with her colleagues on ASPREE study. “Since inflammation is a significant factor in Alzheimer’s disease, it formed the basis of the hypothesis that aspirin could be beneficial in helping to reduce the occurrence of cognitive decline.”

The ASPREE study involved more than 19,000 participants, mostly 70 years of age and older, who did not have heart disease or a diagnosis of dementia. Half the participants received 100mg of aspirin daily and half received a placebo. All participants received a series of memory & thinking tests throughout the study.

“At the end of the five year trial, we identified that aspirin had no effect on dementia regardless of ethnicity, age, gender or an individual’s current health.” said Dr. Ryan, head of the Biological Neuropsychiatry and Dementia Unit at Monash University’s School of Public Health and Preventative Medicine in Melbourne, Australia.

The question remains whether aspirin could be beneficial if begun in mid-life, long before Alzheimer’s disease starts to take hold in the brain. Dr. Ryan feels it is possible that the benefits of low-dose aspirin may not be seen for several more years. For that reason, the National Institute on Aging, which funded the ASPREE trial, has sponsored ongoing monitoring of cognitive function and other health measures for the trial’s participants. However, it will be some years before results are known.

“The ASPREE study provides strong evidence that low-dose aspirin will not reduce the risk of Alzheimer’s disease,” said Dr. Ryan. “While the results are disappointing, the findings are very relevant to older people and their physicians and indicate aspirin should not be prescribed solely on the basis of potential cognitive benefits.”

5 Comments

Filed under Uncategorized

Antibody designed to recognize pathogens of Alzheimer’s disease

Researchers have found a way to design an antibody that can identify the toxic particles that destroy healthy brain cells – a potential advance in the fight against Alzheimer’s disease.

Their method is able to recognize these toxic particles, known as amyloid-beta oligomers, which are the hallmark of the disease, leading to hope that new diagnostic methods can be developed for Alzheimer’s disease and other forms of dementia.

The team, from the University of Cambridge, University College London and Lund University, designed an antibody which is highly accurate at detecting toxic oligomers and quantifying their numbers. Their results are reported in the Proceedings of the National Academy of Sciences (PNAS).

3 Comments

Filed under aging brain, Alzheimer's disease, brain damage, brain function, dementia, Uncategorized

Surgery with anesthesia not associated with indicator of Alzheimer’s disease – Mayo Clinic

Older adults who have surgery with general anesthesia may experience a modest acceleration of cognitive decline, even years later. But there’s no evidence of a link to Alzheimer’s disease, according to new research from Mayo Clinic.

person holding string lights photo

Photo by David Cassolato on Pexels.com

The research, published in the British Journal of Anaesthesia, examined brain scans from 585 patients, ages 70 to 91 ― 493 of whom had at least one surgery with general anesthesia. The analysis found cortical thinning in cerebral areas but no significant evidence of deposits of amyloid protein, a hallmark of Alzheimer’s disease. The cortex is the outermost layer of the brain’s nerve cell tissue, and thinning of that tissue is associated with diminished cognitive functions. Continue reading

Leave a comment

Filed under Alzheimer's disease, Alzheimer's risk, anesthesia, surgery, Uncategorized

Inflammation in the brain linked to several forms of dementia – Study

Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge. The researchers say it offers hope for potential new treatments for several types of dementia.

Inflammation is usually the body’s response to injury and stress – such as the redness and swelling that accompanies an injury or infection. However, inflammation in the brain – known as neuroinflammation – has been recognized and linked to many disorders including depression, psychosis and multiple sclerosis. It has also recently been linked to the risk of Alzheimer’s disease.

brain-18459401920.jpg

In a study published in the journal Brain, a team of researchers at the University of Cambridge set out to examine whether neuroinflammation also occurs in other forms of dementia, which would imply that it is common to many neurodegenerative diseases.

Continue reading

Leave a comment

Filed under aging brain, Alzheimer's disease, brain, brain damage, dementia, inflammation

Diet and Alzheimer’s – Tufts

Herewith another entry in our arsenal against that destroyer of lives – Alzheimer’s Disease, from the Tufts Health & Nutrition Letter.

Alzheimer’s disease accounts for 60 to 80 percent of the loss of memory and other cognitive abilities collectively known as dementia. There is no known food or diet that can prevent or cure Alzheimer’s dementia, but diet may help delay onset and slow progression.

What sets Alzheimer’s apart from other forms of dementia is the excessive buildup of beta-amyloid protein fragments into plaques, as well as defective tau proteins that form tangles in the brain. These changes lead to the death of the nerve cells responsible for everything from memory to movement. There are currently no known dietary factors that can impact the formation of these plaques and tangles, but diet may act in other ways to influence Alzheimer’s and other forms of dementia.

Continue reading

2 Comments

Filed under Alzheimer's disease, Alzheimer's risk, cognition, cognitive decline, dementia, diabetes, high blood pressure, high cholesterol

Understanding the brain/heart connection

Being a senior citizen with a family tree containing both Alzheimer’s Disease and dementia, I read everything I can on the subject. Here is the latest from the Global Council on Brain Health (GCBH).

Screen Shot 2020-02-19 at 5.02.09 PM.png

Did you know that taking care of your heart can reduce your risk for memory and thinking problems? A review of medical research conducted by the Global Council on Brain Health recently showed a reduced risk of dementia with improved heart health. So, let’s review their major findings to learn how we can take better care of our hearts and brains. Continue reading

2 Comments

Filed under Alzheimer's, Alzheimer's disease, dementia, heart, heart health, heart health brain health, Uncategorized

Proximity to major roads linked to increased risk of dementia, Parkinson’s, Alzheimer’s and MS

As a senior citizen whose family has Alzheimer’s Disease and other forms of dementia on both sides, I take these studies very seriously

Living near major roads or highways is linked to higher incidence of dementia, Parkinson’s disease, Alzheimer’s disease and multiple sclerosis (MS), suggests new research published this week in the journal Environmental Health.

action america architecture avenue

Photo by Nout Gons on Pexels.com

Researchers from the University of British Columbia analyzed data for 678,000 adults in Metro Vancouver. They found that living less than 50 meters from a major road or less than 150 meters from a highway is associated with a higher risk of developing dementia, Parkinson’s, Alzheimer’s and MS—likely due to increased exposure to air pollution.

The researchers also found that living near green spaces, like parks, has protective effects against developing these neurological disorders.

Continue reading

2 Comments

Filed under air pollution, Alzheimer's disease, dementia, MS, neurological disorders, Parkinson's disease

Losing one night’s sleep may increase blood levels of Alzheimer’s biomarker – Study

I have written repeatedly about getting a good night’s sleep. You can check my page – How important is a good night’s sleep?  for more details. Regular readers also know about my concern about cognition and the vulnerability of an aging brain because of the Alzheimer’s Disease and dementia in my family.

A preliminary study by researchers at Uppsala University has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau – a biomarker for Alzheimer’s disease – in their blood than when they had a full, uninterrupted night of rest. The study is published in the medical journal Neurology.

cartoon-alarm-clock-vector-482029.jpg

Tau is a protein found in neurons and the protein can form into tangles. These accumulate in the brains of people with Alzheimer’s disease. This accumulation can start decades before symptoms of the disease appear. Previous studies of older adults have suggested that sleep deprivation can increase the level of tau in the cerebral spinal fluid. Trauma to the head can also increase circulating concentrations of tau in blood.

Continue reading

4 Comments

Filed under Alzheimer's disease, brain, brain function, brain health, dementia, good night's sleep, sleep, sleep deprivation