Tag Archives: Alzheimer’s Disease

Losing one night’s sleep may increase blood levels of Alzheimer’s biomarker – Study

I have written repeatedly about getting a good night’s sleep. You can check my page – How important is a good night’s sleep?  for more details. Regular readers also know about my concern about cognition and the vulnerability of an aging brain because of the Alzheimer’s Disease and dementia in my family.

A preliminary study by researchers at Uppsala University has found that when young, healthy men were deprived of just one night of sleep, they had higher levels of tau – a biomarker for Alzheimer’s disease – in their blood than when they had a full, uninterrupted night of rest. The study is published in the medical journal Neurology.

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Tau is a protein found in neurons and the protein can form into tangles. These accumulate in the brains of people with Alzheimer’s disease. This accumulation can start decades before symptoms of the disease appear. Previous studies of older adults have suggested that sleep deprivation can increase the level of tau in the cerebral spinal fluid. Trauma to the head can also increase circulating concentrations of tau in blood.

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What comes first, beta-amyloid plaques or cognition problems?

Because of the dementia and Alzheimer’s Disease in my family, I have an appetite for information on impaired cognition. Following comes from a study by the VA San Diego Healthcare System. Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.

The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology.

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Participants had brain scans at the start of the study to determine levels of amyloid plaques in the brain, and then yearly scans for four years. Image is in the public domain.

“Our research was able to detect subtle thinking and memory differences in study participants and these participants had faster amyloid accumulation on brain scans over time, suggesting that amyloid may not necessarily come first in the Alzheimer’s disease process,” said study author Kelsey R. Thomas, PhD, of the VA San Diego Healthcare System in San Diego. “Much of the research exploring possible treatments for Alzheimer’s disease has focused on targeting amyloid. But based on our findings, perhaps that focus needs to shift to other possible targets.” Continue reading

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Filed under aging brain, Alzheimer's disease, brain, brain function, brain research, dementia, Uncategorized

CoQ10 and its dosage

I have to admit that I have been seeing items and ads about CoQ10 for years and never paid it much attention. I stumbled across this rundown in Medical News Today and was amazed at its functionality. I thought it would interest you.

CoQ10 is an antioxidant that exists in almost every cell of the human body. CoQ10 deficiency is associated with various medical conditions, such as heart disease, cancer, and Alzheimer’s disease.cells.jpg

 

Although the body naturally produces CoQ10, some people may benefit from taking supplements. Overall, CoQ10 supplements appear relatively safe and cause few side effects. Supplements are not regulated by the Food and Drug Administration (FDA) for purity or verified for labeling accuracy, so purchase only those products that have been tested by an independent lab.

People who are interested in trying CoQ10 supplements may want to consult a healthcare professional first. Experts do not recommend CoQ10 for people taking blood-thinning medications, insulin, or certain chemotherapy drugs. Continue reading

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Aging folks worried about dementia risk

Nearly half of Americans in their 50s and early 60s think they’re likely to develop dementia as they grow older, but only 5% of them have actually talked with a doctor about what they could do to reduce their risk, a new study finds. 

Meanwhile, a third or more say they’re trying to stave off dementia by taking supplements or doing crossword puzzles – despite the lack of proof that such tactics work. 

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The new findings suggest a need for better counseling for middle-aged Americans about the steps they can take to keep their brains healthy as they age.

Meanwhile, pharmaceutical companies continue to work on potential dementia-preventing medications. But an over-estimation of future dementia risk by individuals may lead to costly over-use of such products, the researchers warn.

The new results appear in a research letter in the new edition of JAMA Neurology, and a presentation at the Gerontological Society of America’s annual meeting.

Both are by members of a team from the University of Michigan’s Institute for Healthcare Policy and Innovation who analyzed data from a nationally representative poll of 1,019 adults between the ages of 50 and 64.

Donovan Maust, M.D., M.S., a geriatric psychiatrist specializing in dementia-related care and lead author of the JAMA Neurology letter, notes that even among the oldest Americans, the risk of dementia is lower than one in three people over age 85.

Risk starts rising around age 65, and is higher among people of Latino or African-American heritage. Continue reading

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Walking patterns identify specific dementia type – Study

Walking may be a key clinical tool in helping medics accurately identify the specific type of dementia a patient has, pioneering research has revealed.

For the first time, scientists at Newcastle University have shown that people with Alzheimer’s disease or Lewy body dementia have unique walking patterns that signal subtle differences between the two conditions.

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Gait Lab photo

The research, published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, shows that people with Lewy body dementia change their walking steps more – varying step time and length – and are asymmetric when they move, in comparison to those with Alzheimer’s disease.

It is a first significant step towards establishing gait as a clinical biomarker for various subtypes of the disease and could lead to improved treatment plans for patients.

Useful diagnostic tool

Dr Ríona McArdle, Post-Doctoral Researcher at Newcastle University’s Faculty of Medical Sciences, led the Alzheimer’s Society-funded research.

She said: “The way we walk can reflect changes in thinking and memory that highlight problems in our brain, such as dementia.

“Correctly identifying what type of dementia someone has is important for clinicians and researchers as it allows patients to be given the most appropriate treatment for their needs as soon as possible.

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Aging arteries weaken memory – Study

Regular readers know of my concern about aging and its effect on cognition as three of my direct family members suffered from Alzheimer’s Disease and dementia. For that reason I try to keep my arteries flexible through my program of regular exercise. I know that there is no known way to prevent Alzheimer’s, but I am willing to take any physical measures that I can to reduce my chances. Check out my Page  – Important facts about your brain (and exercise benefits) for more details on this subject.

Researchers in Umeå, Sweden, have presented a model that explains why memory deteriorates as the body ages. With age, the brain receives an increased load from the heart’s beating as the body’s large arteries stiffen over the years, causing damage to the smallest blood vessels in the brain.

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The fact that human memory is deteriorating with increasing age is something that most people experience sooner or later, even among those who avoid diseases such as Alzheimer’s. Similarly, a connection between the ageing of the brain and the body is well known. However, the exact nature of this association is not known.

“We suggest a chain of events on how the aging of the brain and vessels are related,” says Lars Nyberg, professor at Umeå University.

What Umeå researchers Lars Nyberg and Anders Wåhlin have created is an explanatory model that starts with the heartbeat, and carries through the largest arteries in the body all the way to the finest vessels in the brain. An important feature of the model is that it provides a rationale why some cognitive processes may be particularly at risk for the proposed mechanism.

As the human body ages, large arteries, such as the aorta, stiffen and lose a large portion of their ability to absorb the pressure increase generated as the heart ejects blood into the arteries. Such pressure pulsatility is instead transmitted to smaller blood vessels, for example those in the brain. The smallest blood vessels in the brain, the capillaries, are subjected to an increased stress that causes damage to cells within and surrounding the capillary walls. These cells are important in the regulation of the capillary blood flow. If the smallest blood vessels are damaged, this is detrimental to the ability to increase the blood supply to the brain when coping with demanding cognitive processes.

According to the researchers’ model, the hippocampus in the brain is particularly vulnerable. The structure in that part of the brain is important for the episodic memory, that is, the ability to remember events from the past. The vulnerability of the hippocampus relates to the fact that it is located close to the large vessels and thus is exposed to the increased load early in the chain. In a young and healthy person, the pulsations are soft, but in an ageing person the pulsations can be so powerful that they affect the brain tissue and can damage the blood supply to memory processes.

The Umeå researchers’ model is based on a number of previous studies from the last five years.

“We have laid the puzzle of current and verified research in different fields to a broader and more detailed picture of the course of events. It will form a starting point for future research to gain a better understanding and, in the long term, researchers may also find solutions to slow down the process,” says Anders Wåhlin.

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10 Brain-saving techniques – Alzheimer’s Association

As regular readers know, I am very sensitive to cognitive impairment, having lost three close family members to Alzheimer’s and dementia. So I was very happy to come across this list of recommendations for building up our mental muscles and reducing our chances of contracting Alzheimer’s from the Alzheimer’s Association.

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“Research on cognitive decline is still evolving,” said Theresa Hocker, president and CEO of the Alzheimer’s Association – North Central Texas Chapter. “But there are actions people can take. Certain healthy behaviors known to combat cancer, cardiovascular disease and diabetes also may reduce the risk of cognitive decline. These include staying mentally active, engaging in regular physical activity, and eating a heart-healthy diet that benefits your body and your brain.”

1. Break a sweat. Engage in regular cardiovascular exercise that elevates your heart rate and increases blood flow to the brain and body. Several studies have found an association between physical activity and reduced risk of cognitive decline.

2. Hit the books. Formal education in any stage of life will help reduce your risk of cognitive decline and dementia. For example, take a class at a local college, community center or online.

3. Butt out. Evidence shows that smoking increases risk of cognitive decline. Quitting smoking can reduce that risk to levels comparable to those who have not smoked. Continue reading

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New blood test for Alzheimer’s – Study

There is possible good news is the study of Alzheimer’s disease. Researchers from Lund University, together with the Roche pharmaceutical company, have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer’s disease. If the method is approved for clinical use, the researchers hope eventually to see it used as a diagnostic tool in primary healthcare. This autumn, they will start a trial in primary healthcare to test the technique.

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Currently, a major support in the diagnostics of Alzheimer’s disease is the identification of abnormal accumulation of the substance beta-amyloid, which can be detected either in a spinal fluid sample or through brain imaging using a PET scanner. Continue reading

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Some dementia patients show moments of clarity at end of life – Study

It happens unexpectedly: a person long thought lost to the ravages of dementia, unable to recall the events of their lives or even recognize those closest to them, will suddenly wake up and exhibit surprisingly normal behavior, only to pass away shortly thereafter. This phenomenon, which experts refer to as terminal or paradoxical lucidity, has been reported since antiquity, yet there have been very few scientific studies of it. That may be about to change.

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In an article published in the August issue of Alzheimer’s & Dementia , an interdisciplinary workgroup convened by the National Institutes of Health’s (NIH) National Institute on Aging and led by Michigan Medicine’s George A. Mashour, M.D., Ph.D., outlines what is known and unknown about paradoxical lucidity, considers its potential mechanisms, and details how a thorough scientific analysis could help shed light on the pathophysiology of dementia. Continue reading

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Detection of early stage Alzheimer’s in blood – Study

Two major studies with promising antibodies have recently failed – possibly because they have been administered too late. A new very early-detection test gives rise to hope.

Using current techniques, Alzheimer’s disease, the most frequent cause of dementia, can only be detected once the typical plaques have formed in the brain. At this point, therapy seems no longer possible. However, the first changes caused by Alzheimer’s take place on the protein level up to 20 years sooner. A two-tier method developed at Ruhr-Universität Bochum (RUB) can help detect the disease at a much earlier stage. The researchers from Bochum published their report in the March 2019 edition of the journal “Alzheimer’s and Dementia: Diagnosis, Assessment and Disease Monitoring”.

 

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“This has paved the way for early-stage therapy approaches, where the as yet inefficient drugs on which we had pinned our hopes may prove effective,” says Professor Klaus Gerwert from the Department of Biophysics at RUB.

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Researchers Define Alzheimer’s-like Brain Disorder

As regular readers know, I have a history of Alzheimer’s Disease or some form of dementia on both sides of my family, so I entertain a strong interest in the subject, particularly since I am a senior citizen.

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A brain disorder that mimics symptoms of Alzheimer’s disease has been defined with recommended diagnostic criteria and guidelines for advancing future research on the condition. Researchers at Rush University Medical Center and scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly named pathway to dementia, limbic-predominant age-related TDP-43 encephalopathy, or LATE, in a report published today in the journal Brain.

“We proposed a new name to increase recognition and research for this common cause of dementia, the symptoms of which mimic Alzheimer’s dementia but is not caused by plaques and tangles (the buildup of beta amyloid proteins that Alzheimer’s produces). Rather, LATE dementia is caused by deposits of a protein called TDP-43 in the brain,” said Dr. Julie Schneider, senior author of the Brain paper and associate director of the Rush Alzheimer’s Disease Center. Continue reading

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Home-Based Tools May Help Assess Dementia Risk and Progression – Study

As my family has had several cases of dementia, some in the form of Alzheimer’s, I am always captivated by tools for assessing risk as I am a senior citizen. This University of California San Diego School of Medicine study caught my eye.

Clinical trials to develop new therapeutic and preventive treatments for Alzheimer’s disease (AD) are costly, complicated and often preclude persons most at risk of developing the degenerative neurological condition: Older individuals with less mobility and significant medical issues, both making it more difficult for them to participate in traditional, clinic-based assessments with trained personnel.

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In a new paper, published this month in the journal Alzheimer’s & Dementia, a multi-institution team led by researchers at Alzheimer’s Disease Cooperative Study (ADCS) at University of California San Diego School of Medicine published results of a novel four-year, randomized clinical trial evaluating different home-based methods to assess cognitive function and decline in participants over the age of 75.

Almost 600 persons participated in the home-based assessment (HBA) study; all had been previously diagnosed as either possessing normal cognitive abilities or suffering from Mild Cognitive Impairment, a condition that often precedes AD. Continue reading

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FDA takes action against 17 companies for illegally selling products making Alzheimer’s disease claims

As I have written here numerous times, both sides of my family have a history of Alzheimer’s Disease, the most common form of dementia. As a guy in his late 70’s this is a critical subject for me. And I am not the only one. I live near Northwestern Memorial Hospital, a major Chicago health establishment. They have a Healthy Transitions program there for folks over 50 which provides programs explaining the changes we are experiencing and can expect to experience. The most popular are the ones dealing with cognitive impairment, Alzheimer’s and dementia. We are all concerned.

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Photo by David Cassolato on Pexels.com

That’s why I hope there is a special place in hell for companies who prey on the fears of seniors about their mental health and capacities. I found this item from the U.S. Food and Drug Administration (FDA) most satisfying. Continue reading

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Alzheimer’s blood test detects brain damage years before symptoms – Study

A blood test for a protein could identify people in the early stages of Alzheimer’s disease a decade or more before symptoms, such as a decline in memory and thinking, emerge, as reported in Medical News Today.

This was what an international group of scientists concluded after evaluating the simple test that used blood samples from people with a rare form of Alzheimer’s disease that they had inherited.

The team included researchers from Washington University School of Medicine in St. Louis, MO and the German Center for Neurodegenerative Diseases in Tübingen, Germany.

The test looks for changes in levels of the neurofilament light chain (NfL) protein. The protein normally resides inside brain cells, or neurons, as part of their internal skeleton.

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However, damaged and dying cells can leak NfL into surrounding cerebrospinal fluid. The protein then travels from the fluid into the bloodstream. Continue reading

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Eyes provide new lens for Alzheimer’s screening

At the risk of repeating myself I have a strong interest in any form of dementia and especially Alzheimer’s Disease as I have had at least three close family members succumb – and I am a senior citizen.  the folowing is from the University of Washington School of Medicine.

Alzheimer’s disease is difficult to diagnose as well as treat,  but researchers now have a promising new screening tool using the window to the brain:  the eye.

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A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases – age-related macular degeneration, diabetic retinopathy and glaucoma – and Alzheimer’s disease.

The results offer physicians a new way to detect  those at higher risk of this disorder, which causes memory loss and other symptoms of cognitive decline. Continue reading

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Meditation and Music May Alter Blood Markers of Cellular Aging and Alzheimer’s Disease in Adults with Early Memory Loss

A research team led by Dr. Kim Innes, a professor in the West Virginia University School of Public Health, has found that a simple meditation or music listening program may alter certain biomarkers of cellular aging and Alzheimer’s Disease in older adults who are experiencing memory loss. Study findings, reported in the Journal of Alzheimer’s Disease, also suggest these changes may be directly related to improvements in memory and cognition, sleep, mood, and quality of life.

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Sixty older adults with subjective cognitive decline (SCD), a condition that may represent a preclinical stage of Alzheimer’s disease, participated in the randomized, clinical trial. While SCD has been linked to increased risk for dementia and associated with certain neuropathological changes implicated in Alzheimer’s disease development, including elevated brain levels of beta amyloid, this preclinical period may also provide a critical window for therapeutic intervention.

In this trial, each participant was randomly assigned to either a beginner meditation (Kirtan Kriya) or music listening program and asked to practice 12 minutes/day for 12 weeks. At baseline and 3 months, blood samples were collected. Two markers of cellular aging were measured: telomere length and telomerase activity. (Telomeres serve as protective caps on chromosomes; telomerase is an enzyme responsible for maintaining telomere length). Blood levels of specific beta-amyloid peptides commonly linked to Alzheimer’s Disease were also assessed. In addition, memory and cognitive function, stress, sleep, mood, and quality of life were measured. All participants were followed for a total of 6 months. Continue reading

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