Neurons lack the ability to replicate their DNA, so they’re constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but instead focus on protecting certain genetic “hot spots” that appear to play a critical role in neural identity and function, according to Science Daily.
The findings, published in the April 2, 2021, issue of Science, give novel insights into the genetic structures involved in aging and neuro-degeneration, and could point to the development of potential new therapies for diseases such Alzheimer’s, Parkinson’s and other age-related dementia disorders.
“This research shows for the first time that there are sections of genome that neurons prioritize when it comes to repair,” says Professor and Salk President Rusty Gage, the paper’s co-corresponding author. “We’re excited about the potential of these findings to change the way we view many age-related diseases of the nervous system and potentially explore DNA repair as a therapeutic approach.”
Scientists have more evidence that exercise improves brain health and could be a lifesaving ingredient that prevents Alzheimer’s disease.
In particular, a new study from the University of Texas (UT) Southwestern’s O’Donnell Brain Institute suggests that the lower the fitness level, the faster the deterioration of vital nerve fibers in the brain. This deterioration results in cognitive decline, including memory issues characteristic of dementia patients.
“This research supports the hypothesis that improving people’s fitness may improve their brain health and slow down the aging process,” said Dr. Kan Ding, a neurologist from the Peter O’Donnell Jr. Brain Institute who authored the study.
The study published in the Journal of Alzheimer’s Disease focused on a type of brain tissue called white matter, which is comprised of millions of bundles of nerve fibers used by neurons to communicate across the brain.
Dr. Ding’s team enrolled older patients at high risk to develop Alzheimer’s disease who have early signs of memory loss, or mild cognitive impairment (MCI). The researchers determined that lower fitness levels were associated with weaker white matter, which in turn correlated with lower brain function.
Unlike previous studies that relied on study participants to assess their own fitness, the new research objectively measured cardiorespiratory fitness with a scientific formula called maximal oxygen uptake. Scientists also used brain imaging to measure the functionality of each patient’s white matter.
Patients were then given memory and other cognitive tests to measure brain function, allowing scientists to establish strong correlations between exercise, brain health, and cognition.
The study adds to a growing body of evidence pointing to a simple yet crucial mandate for human health: Exercise regularly.
However, the study leaves plenty of unanswered questions about how fitness and Alzheimer’s disease are intertwined. For instance, what fitness level is needed to notably reduce the risk of dementia? Is it too late to intervene when patients begin showing symptoms?
Some of these topics are already being researched through a five-year national clinical trial led by the O’Donnell Brain Institute.
The trial, which includes six medical centers across the country, aims to determine whether regular aerobic exercise and taking specific medications to reduce high blood pressure and cholesterol levels can help preserve brain function. It involves more than 600 older adults at high risk to develop Alzheimer’s disease.
“Evidence suggests that what is bad for your heart is bad for your brain. We need studies like this to find out how the two are intertwined and hopefully find the right formula to help prevent Alzheimer’s disease,” said Dr. Rong Zhang of UT Southwestern, who oversees the clinical trial and is Director of the Cerebrovascular Laboratory in the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, where the Dallas arm of the study is being carried out.
The research builds upon prior investigations linking healthy lifestyles to better brain function, including a 2013 study from Dr. Zhang’s team that found neuronal messages are more efficiently relayed in the brains of older adults who exercise.
In addition, other teams at the O’Donnell Brain Institute are designing tests for the early detection of patients who will develop dementia, and seeking methods to slow or stop the spread of toxic proteins associated with the disease such as beta-amyloid and tau, which are blamed for destroying certain groups of neurons in the brain.
“A lot of work remains to better understand and treat dementia,” said Dr. Ding, Assistant Professor of Neurology & Neurotherapeutics. “But, eventually, the hope is that our studies will convince people to exercise more.
Higher BMI is linked to decreased cerebral blood flow, which is associated with increased risk of Alzheimer’s disease and mental illness, according to a new study in the Journal of Alzheimer’s Diseast (JAD).
As a person’s weight goes up, all regions of the brain go down in activity and blood flow, according to a new brain imaging study in the Journal of Alzheimer’s Disease. One of the largest studies linking obesity with brain dysfunction, scientists analyzed over 35,000 functional neuro-imaging scans using single-photon emission computerized tomography from more than 17,000 individuals to measure blood flow and brain activity.
Low cerebral blood flow is the #1 brain imaging predictor that a person will develop Alzheimer’s disease. It is also associated with depression, ADHD, bipolar disorder, schizophrenia, traumatic brain injury, addiction, suicide, and other conditions. “This study shows that being overweight or obese seriously impacts brain activity and increases the risk for Alzheimer’s disease as well as many other psychiatric and cognitive conditions,” explained Daniel G. Amen, MD, the study’s lead author and founder of Amen Clinics, one of the leading brain-centered mental health clinics in the United States.
Primary care clinics can play an important role in preserving patients’ brain health using the American Heart Association’s Life’s Simple 7 as a guide, as well as addressing six other factors associated with cognitive decline, according to a new American Stroke Association/American Heart Association Scientific Statement, “A Primary Care Agenda for Brain Health.
The statement was published in the Association’s journal Stroke. Led by researchers at the University of Alabama at Birmingham, it has been endorsed by the American Academy of Neurology as an educational tool for neurologists.
Preserving brain health in an aging population is a growing concern in the United States. An estimated one in five Americans 65 years and older has mild cognitive impairment, and one in seven has dementia. By 2050, the number of Americans with dementia is expected to triple, the statement authors note.
“Primary care is the right home for practice-based efforts to prevent or postpone cognitive decline. Primary care professionals are most likely to identify and monitor risk factors early and throughout the lifespan,” said the chair of the scientific statement writing group, Ronald M. Lazar, Ph.D., the Evelyn F. McKnight Endowed Chair for Learning and Memory in Aging and director of the Evelyn F. McKnight Brain Institute at the UAB School of Medicine. “Prevention doesn’t start in older age; it exists along the health care continuum from pediatrics to adulthood. The evidence in this statement demonstrates that early attention to these factors improves later life outcomes.”
Primary care doctors can play an important role in helping to preserve brain health by encouraging healthy behaviors and addressing risk factors associated with cognitive decline, according to a new scientific report.
The American Heart Association statement published in the journal Stroke outlines seven lifestyle targets and six risk factors for brain health that primary care doctors should address in adults of all ages. The statement also has been endorsed by the American Academy of Neurology as an educational tool for neurologists.
As the nation ages, preserving brain health has become a growing concern. Mild cognitive impairment affects an estimated 1 in 5 Americans age 65 and older; 1 in 7 has dementia – a number expected to triple by 2050.
“Primary care is the right home for practice-based efforts to prevent or postpone cognitive decline,” Ronald Lazar, chair of the scientific statement writing group, said in a news release. Lazar directs the Evelyn F. McKnight Brain Institute at the University of Alabama at Birmingham.
“Prevention doesn’t start in older age; it exists along the health care continuum from pediatrics to adulthood,” he said. “The evidence in this statement demonstrates that early attention to these factors improves later life outcomes.”
The statement asks primary care doctors to integrate brain health into their treatment of adults guided by the AHA’s Life’s Simple 7, a collection of lifestyle targets shown to help achieve ideal heart and brain health. These include managing blood pressure, cholesterol and blood sugar levels; increasing physical activity; eating a healthy diet; losing weight; and not smoking.
The statement also asks them to assess their patients’ risk factors for cognitive health, including depression, social isolation, excessive alcohol use, sleep disorders, lower education levels and hearing loss.
“Scientists are learning more about how to prevent cognitive decline before changes to the brain have begun,” Lazar, a professor of neurology and neurobiology, said. “We have compiled the latest research and found Life’s Simple 7 plus other factors like sleep, mental health and education are a more comprehensive lifestyle strategy that optimizes brain health in addition to cardiovascular health.”
Dr. Deborah Levine, one of the statement’s co-authors, said it is never too soon to target risk factors for ideal heart and brain health. It’s also never too late.
“For example, lower blood pressure levels reduce the risk of cognitive impairment and dementia in older adults,” she said. “In adults of all ages, the metrics in Life’s Simple 7 prevent stroke, and stroke increases the risk of dementia by more than twofold.”
Additional risk factors can help physicians identify which patients may need special attention, said Levine, an associate professor of medicine at the University of Michigan Medical School in Ann Arbor.
For example, “Primary care doctors can help their patients reduce dementia risk by identifying and aggressively treating vascular risk factors like high blood pressure. Black and Hispanic individuals, women and individuals with lower educational levels appear at higher risk for dementia, so these high-risk groups are a top priority,” Levine said.
According to the statement, recent research shows high blood pressure, diabetes and smoking in adulthood and midlife increase the odds of cognitive decline in middle age. And they accelerate cognitive decline in older age.
“Many people think of high blood pressure, Type 2 diabetes and other risk factors as affecting only heart health, yet these very same risk factors affect our brain health,” Lazar said. “Patients might be more likely to pay attention to the importance of addressing modifiable risk factors if they understood the links.”
The statement defines brain health using the term cognition, which includes memory, thinking, reasoning, communication and problem-solving.
Together, these functions enable people to navigate the everyday world, according to the report. The ability to think, solve problems, remember, perceive and communicate are crucial to successful living; their loss can lead to helplessness and dependency.
“Studies have shown that these domains are impacted by factors that are within our control to change,” Lazar said. “Prevention and mitigation are important, because once people have impaired cognition, the current treatment options are very limited.”
Music-based interventions have become a core ingredient of effective neurorehabilitation in the past 20 years thanks to the growing body of knowledge. In this theme issue of Neurorehabilitation, experts in the field highlight some of the current critical gaps in clinical applications that have been less thoroughly investigated, such as post-stroke cognition, traumatic brain injury, and autism and specific learning disabilities.
Neurologic Music Therapy is the clinical and evidence-based use of music interventions by a credentialed professional. Research in the 1990s showed for the first time how musical-rhythmic stimuli can improve mobility in stroke and Parkinson’s disease patients. We now know that music-based interventions can effectively address a wide range of impairments in sensorimotor, speech/language, and cognitive functions.
A new study led by the University of Portsmouth has identified that one of the major factors of age-related brain deterioration is the loss of a substance called myelin.
Myelin acts like the protective and insulating plastic casing around the electrical wires of the brain – called axons. Myelin is essential for superfast communication between nerve cells that lie behind the supercomputer power of the human brain.
The loss of myelin results in cognitive decline and is central to several neurodegenerative diseases, such as Multiple Sclerosis and Alzheimer’s disease. This new study found that the cells that drive myelin repair become less efficient as we age and identified a key gene that is most affected by ageing, which reduces the cells ability to replace lost myelin.
People with prediabetes, whose blood sugar levels are higher than normal, may have an increased risk of cognitive decline and vascular dementia, according to a new study led by University College London (UCL) researchers.
For the study, published in the journal Diabetes, Obesity and Metabolism, researchers analyzed data from the UK Biobank of 500,000 people aged 58 years on average, and found that people with higher than normal blood sugar levels were 42% more likely to experience cognitive decline over an average of four years, and were 54% more likely to develop vascular dementia over an average of eight years (although absolute rates of both cognitive decline and dementia were low).
The associations remained true after other influential factors had been taken into account – including age, deprivation, smoking, BMI and whether or not participants had cardiovascular disease.
Previous research has led to findings that support links between a positive mental outlook and physical health benefits such as lower blood pressure, less heart disease, and healthier blood sugar levels. In a recent study of mood changes in older adults, scientists also have discovered that healthy brain function may result in maintaining a positive outlook.
For this study, which was funded in part by NIA and published in the American Journal of Geriatric Psychiatry in September 2020, scientists proposed a potential neurobiological connection between an older adult’s mood with changes, over a period of time, in white brain matter and cognitive ability. White matter is where information is transmitted from one brain region to another. As we age, changes can occur in the white matter that may lead to thinking, walking, and balance problems.
A new study shows a sort of signature in the brains of lonely people that make them distinct in fundamental ways, based on variations in the volume of different brain regions as well as based on how those regions communicate with one another across brain networks.
This holiday season will be a lonely one for many people as social distancing due to COVID-19 continues, and it is important to understand how isolation affects our health. A new study shows a sort of signature in the brains of lonely people that make them distinct in fundamental ways, based on variations in the volume of different brain regions as well as based on how those regions communicate with one another across brain networks.
A team of researchers examined the magnetic resonance imaging (MRI) data, genetics and psychological self-assessments of approximately 40,000 middle-aged and older adults who volunteered to have their information included in the UK Biobank: an open-access database available to health scientists around the world. They then compared the MRI data of participants who reported often feeling lonely with those who did not.
The foods we eat may have a direct impact on our cognitive acuity in our later years. This is the key finding of an Iowa State University research study spotlighted in an article published in the November 2020 issue of the Journal of Alzheimer’s Disease.
The study was spearheaded by principal investigator, Auriel Willette, an assistant professor in Food Science and Human Nutrition, and Brandon Klinedinst, a Neuroscience PhD candidate working in the Food Science and Human Nutrition department at Iowa State. The study is a first-of-its-kind large scale analysis that connects specific foods to later-in-life cognitive acuity.
Concussions are the most common form of mild brain injury, affecting over 42 million people worldwide annually. Their long-term risks — especially for athletes and members of the military — are well documented, with studies showing possible connections to neurodegenerative conditions like chronic traumatic encephalopathy and Alzheimer’s disease.
The immediate effects of a concussion are well known, such as alterations in the brain’s structure and activity seen soon after injury. In addition to symptoms like headaches and light sensitivity, a concussion often causes difficulty concentrating or trouble processing new information that can linger for a few weeks before clearing up. But less is understood about how a concussion from earlier in our lives can impact the brain and cognitive health as we age.
AS a guy who has a bluetooth speaker on his bike’s water bottle, I don’t need anyone to tell me to enjoy music. But, in case you do ….
Music has been with us since ancient times. It has framed the cultures, rituals and celebrations of our lives. It’s a universal language that brings people together. Now, researchers are discovering the reasons why music can have such a profound impact on our brains and bodies.
AARP convened the Global Council on Brain Health (GCBH) in February of 2020 to explore the impact of music on brain health. Each year, GCBH reviews research to give older adults the best possible advice for maintaining brain health. Let’s review some of their findings and recommendations for engaging in music to improve brain health.
A hot cup of coffee or tea is a highlight of the morning for some people. It can make you feel awake and alert. Caffeine is the chemical that causes these sensations. But does caffeine have other effects on the brain?
Caffeine is found naturally in tea and coffee. But it is added to energy drinks and many types of soda. It’s even put in some snack foods and medications. More than eight out of 10 adults in the U.S. consume caffeine in some form.
So how does caffeine wake you up? Your body naturally produces a chemical called adenosine. It builds up in your body during the day.
Subtle differences in cognition may help identify individuals at risk for becoming dependent years later upon others to complete daily activities, such as managing medications or finances and other essential activities.
Writing in the September 29, 2020 online issue of the Journal of Alzheimer’s Disease, researchers at University of California San Diego School of Medicine, with colleagues elsewhere, linked poorer cognitive performance in a single testing with subsequent greater risk for impaired daily life activities nearly a decade later.
The study involved a diverse but understudied cohort of Latinos living in the United States. Outcomes were most severe for individuals 70 years and older, but gender and ethnic background, such as Mexican or Puerto Rican, were not significant differentiators. The authors said the findings in sum highlight the need for early preventive care across Latinos and Latinas of various backgrounds.
By now I think everybody reading this blog knows about my family’s connection to Alzheimer’s and dementia. So,it should come as no surprise that I am thrilled to pass on this latest info from the Alzheimer’s Prevention Registry.
A promising new blood test for Alzheimer’s disease is now on the horizon. The newly reported test proved to be just as reliable as more invasive and costly tests at detecting Alzheimer’s and may even be able to detect the disease as long as 20 years prior to symptoms. This is an exciting new development that could make detecting the disease much easier and speed up enrollment in clinical trials.