A team of scientists has successfully trained a new artificial intelligence (AI) algorithm to make accurate predictions regarding cognitive decline leading to Alzheimer’s disease.
Dr. Mallar Chakravarty, a computational neuroscientist at the Douglas Mental Health University Institute, and his colleagues from the University of Toronto and the Center for Addiction and Mental Health, designed an algorithm that learns signatures from magnetic resonance imaging (MRI), genetics, and clinical data. This specific algorithm can help predict whether an individual’s cognitive faculties are likely to deteriorate towards Alzheimer’s in the next five years.
“At the moment, there are limited ways to treat Alzheimer’s and the best evidence we have is for prevention. Our AI methodology could have significant implications as a ‘doctor’s assistant’ that would help stream people onto the right pathway for treatment. For example, one could even initiate lifestyle changes that may delay the beginning stages of Alzheimer’s or even prevent it altogether,” says Chakravarty, an Assistant Professor in McGill University’s Department of Psychiatry. Continue reading
I don’t know if these really will increase your brain power, but I don’t see any harm in letting you know about them.
Please let me know if you have any experience with these.To my knowledge they are all excellent foods nutritionally.
They say you can’t teach old dogs new tricks, but new research shows you can teach an old rat new sounds, even if the lesson doesn’t stick very long.
For the record I wrote a post on that damaging cliche about teaching old dogs new tricks. You can read it here – Of cats and dogs and cliches ….
Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University examined the effects of aging on neuroplasticity in the primary auditory cortex, the part of the brain that processes auditory information. Neuroplasticity refers to the brain’s ability to modify its connections and function in response to environmental demands, an important process in learning.
Plasticity in the young brain is very strong as we learn to map our surroundings using the senses. NeuroscienceNews.com image is in the public domain.
Plasticity in the young brain is very strong as we learn to map our surroundings using the senses. As we grow older, plasticity decreases to stabilize what we have already learned. This stabilization is partly controlled by a neurotransmitter called gamma-Aminobutyric acid (GABA), which inhibits neuronal activity. This role of GABA was discovered by K.A.C. Elliot and Ernst Florey at The Neuro in 1956. Continue reading
The living longer phrase in my Diet, Exercise and Living Longer title assumes that one has his mental faculties intact. Having seen first hand the scourge of dementia, I don’t want any part of that if I can help it. Exercise is super for combating cognitive problems. Check out my Page – Important facts about your brain – (and exercise benefits) to learn more.
The blueberry, already labeled a ‘super fruit’ for its power to potentially lower the risk of heart disease and cancer, also could be another weapon in the war against Alzheimer’s disease. New research being presented today further bolsters this idea, which is being tested by many teams. The fruit is loaded with healthful antioxidants, and these substances could help prevent the devastating effects of this increasingly common form of dementia, scientists report.
The researchers presented their work at the National Meeting & Exposition of the American Chemical Society (ACS). ACS. It featured more than 12,500 presentations on a wide range of science topics. Continue reading
I feel very strongly about smoking. This is one of those Captain Obvious things to me. It astounds me that anyone who can read will continue to smoke.
The following is excerpted from my Page – How many ways does smoking harm you? Check it out for chapter and verse on the multi-faceted damage that smoking does to your body.
Tobacco use is the single largest cause of preventable cause of death in the United States.
On average people who smoke die about 10 years sooner than non-smokers. The New England Journal of Medicine.
Smoking triples the risk for cataracts and is also a risk factor for macular degeneration and its response to treatment. Dr. Nicholas Volpe, Tarry Professor and Chairman Department of Opthalmology Feinberg School of Medicine Northwestern University
The American Cancer Society estimates that in 2014 about 224,000 new cases of lung cancer and 159,260 cancer deaths caused by tobacco use. The overall survival rate for those with lung cancer, sadly, remains at around 15%. You have less than one chance in six of surviving. Continue reading
You don’t have to be a senior to suffer from cognitive impairment. Here are some hopefully helpful hints for self-assessment from the Alzheimer’s Association.
I am a big supporter of Positivity. You can check out my Page, which includes a super graphic video, Positive psychology – What’s it all about?
The following study was written up by Anne Trafton of the MIT News office.
Many patients with neuropsychiatric disorders such as anxiety or depression experience negative moods that lead them to focus on the possible downside of a given situation more than the potential benefit.
MIT neuroscientists have found that stimulating part of the striatum can induce feelings of pessimism. (Anatomography/Life Science Databases)
MIT neuroscientists have now pinpointed a brain region that can generate this type of pessimistic mood. In tests in animals, they showed that stimulating this region, known as the caudate nucleus, induced animals to make more negative decisions: They gave far more weight to the anticipated drawback of a situation than its benefit, compared to when the region was not stimulated. This pessimistic decision-making could continue through the day after the original stimulation. Continue reading
Reduced levels of plasmalogens—a class of lipids created in the liver that are integral to cell membranes in the brain—are associated with an increased risk of Alzheimer’s Disease, according to new research presented this week at the Alzheimer’s Association International Conference (AAIC) 2018 by Mitchel A. Kling, MD, an associate professor of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania and the Veterans Affairs Medical Center.
Plasmalogens are created in the liver and are dispersed through the blood stream in the form of lipoproteins, which also transport cholesterol and other lipids to and from cells and tissues throughout the body, including the brain. Kling, and the multi-institutional Alzheimer’s Disease Metabolomics Consortium led by Rima F. Kaddurah-Daouk, PhD, at Duke University School of Medicine, developed three indices for measuring the amount of these lipids related to cognition, in order to identify whether reduced levels in the bloodstream are associated with an increased risk of Alzheimer’s disease, mild cognitive impairment (MCI), overall cognitive function, and/or other biomarkers of neurodegeneration in Alzheimer’s disease. The three indices measured: the ratios of plasmalogens to each other; the ratios of plasmalogens to their closely-related, more conventional lipid counterparts; and a combination of these two quantities. Continue reading
I confess, I am blown away by the brain. I took a course in it from The Great Courses and have published a number of posts on it. The direct connection between physical exercise and the brain never ceases to amaze me. You can check out my Page – Important facts about your brain – (and exercise benefits) to read more.
Eat less; move more; live longer. It’s never too late to start.
Exercising regularly throughout life is the best way to keep your heart healthy. But starting to exercise even in late middle age may lessen the risk of heart failure, according to a report in the May 15 issue of Circulation. Heart failure, a gradual decline in the heart’s ability to pump enough blood to meet the body’s needs, affects about 6.5 million people in the United States.
The study involved more than 11,000 people who were part of a long-running project begun in the late 1980s, the Atherosclerosis Risk in Communities Study. Every six years, participants got medical testing and filled out questionnaires about their physical activity.
People who followed federal recommendations for physical activity (see How much physical activity do you need?) for the first 12 years of the study had the lowest risk of heart failure—31% lower than people who didn’t exercise at all. But people who increased their physical activity levels starting around age 60 over a period of just six years lowered their risk by 12%.
I have talked a lot about Alzheimer’s Disease and dementia over the past eight years, so when I ran across this explanation from the Mayo Clinic, I thought I would share it with you.
These terms are often used interchangeably, but they actually have very different meanings. Dementia is not a specific disease. It’s an overall term, sometimes referred to as an umbrella term, which describes a wide range of symptoms. These symptoms impact a person’s ability to perform everyday activities independently. Common symptoms include:
A decline in memory
Changes in thinking skills
Poor judgment and reasoning skills
Decreased focus and attention
Changes in language and communication skills
Alzheimer’s disease is one type of dementia, but it’s not the only one. There are many different types and causes of dementia, including:
Lewy body dementia
Parkinson’s disease dementia
Alzheimer’s disease, however, is the most well-known and common form of dementia but not everyone with dementia has Alzheimer’s disease.
I thought this had some good information in it. I hope you are able to read the explanations.
As I have said numerous times here, I love it when fresh news meets my bias. The one I am thinking about is how physical exercise benefits brain function. You can check out my post – Can exercise help me to learn? And, don’t forget my Page – Important facts about your brain – and exercise benefits.
If you want to learn to walk a tightrope, it’s a good idea to go for a short run after each practice session. That’s because a recent study in NeuroImage demonstrates that exercise performed immediately after practicing a new motor skill improves its long-term retention. More specifically, the research shows, for the first time, that as little as a single fifteen-minute bout of cardiovascular exercise increases brain connectivity and efficiency. It’s a discovery that could, in principle, accelerate recovery of motor skills in patients who have suffered a stroke or who face mobility problems following an injury. Continue reading
Good news and bad news? Which do you want to hear first? Isn’t that always one of the toughest questions ever?
Summary: Researchers report the brain’s reward network could play an influential role in evaluating the opportunity to gain new information, just as it does to evaluate rewards such as food or financial gain. Source: University College London (UCL)
The researchers found that activity in the brain’s reward system – the nucleus accumbens and ventral tegmental area – in response to the opportunity to receive information about good lotteries, but not about bad lotteries, displayed a pattern similar to what is observed in response to material rewards. This brain signal was independent from the brain response observed when participants found out whether they won or lost the lottery and predicted their preference for information. NeuroscienceNews.com image is in the public domain.
We have a ‘thirst for knowledge’ but sometime ‘ignorance is bliss,’ so how do we choose between these two mind states at any given time?
UCL psychologists have discovered our brains use the same algorithm and neural architecture to evaluate the opportunity to gain information, as it does to evaluate rewards like food or money. Continue reading
A new study in Cardiovascular Research, published by Oxford University Press, indicates that patients with high blood pressure are at a higher risk of developing dementia. This research also shows (for the first time) that an MRI can be used to detect very early signatures of neurological damage in people with high blood pressure, before any symptoms of dementia occur.
High blood pressure is a chronic condition that causes progressive organ damage. It is well known that the vast majority of cases of Alzheimer’s disease and related dementia are not due to genetic predisposition but rather to chronic exposure to vascular risk factors.
The clinical approach to treatment of dementia patients usually starts only after symptoms are clearly evident. However, it has becoming increasingly clear that when signs of brain damage are manifest, it may be too late to reverse the neurodegenerative process. Physicians still lack procedures for assessing progression markers that could reveal pre-symptomatic alterations and identify patients at risk of developing dementia.
Researchers screened subjects admitted at the Regional Excellence Hypertension Center of the Italian Society of Hypertension in the Department of Angiocardioneurology and Translational Medicine of the I.R.C.C.S, Neuromed, in Italy. Researchers recruited people aged 40 to 65, compliant to give written informed consent and with the possibility to perform a dedicated 3 Tesla MRI scan. Continue reading
Eat less; move more; live longer remains the mantra of this blog. Herewith another example of the value of the move more element. We all want to live longer, but that has little meaning if we don’t have a fully functional brain to power us through. I talk about the value of exercise regularly here. Now we have a study that quantifies the amount of movement relevant to benefit our brain.
We know that exercise may help improve thinking skills. But how much exercise? And for how long?
To find the answers, researchers led by Joyce Gomes-Osman, Ph.D., PT, assistant professor of clinical physical therapy and neurology at the University of Miami Miller School of Medicine, reviewed all of the studies in which older adults were asked to exercise for at least four weeks and then take tests of thinking and memory skills. Their results were compared to those of people who did not start a new exercise routine. The review was published in the May 30 online issue of Neurology Clinical Practice, an official journal of the American Academy of Neurology.
The researchers found that people who exercised an average of at least 52 hours over about six months for about an hour each session may improve their thinking skills. In contrast, people who exercised for an average of 34 hours over the same time period did not show any improvement in their thinking skills. Continue reading