Tag Archives: brain

Common nutrient supplementation may hold the answers to combating Alzheimer’s disease -Study

Everyone knows that there is no cure for Alzheimer’s Disease. One of the problems is that by the time  that symptoms become apparent, the disease has progressed so far as to be irreversible. This new study, however, appears to offer the chance of heading off the disease before it gets out of hand.

In a new study, Biodesign researchers reveal that a lifelong dietary regimen of choline holds the potential to prevent Alzheimer’s disease (AD).

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Choline is a safe and easy-to-administer nutrient that is naturally present in some foods and can be used as a dietary supplement. Lead author Ramon Velazquez and his colleagues at the ASU-Banner Neurodegenerative Disease Research Center (NDRC) looked into whether this nutrient could alleviate the effects of Alzheimer’s.

Earlier this year, Velazquez and colleagues found transgenerational benefits of AD-like symptoms in mice whose mothers were supplemented with choline. The latest work expands this line of research by exploring the effects of choline administered in adulthood rather than in fetal mice.

The study focuses on female mice bred to develop AD-like symptoms. Given the higher prevalence of AD in human females, the study sought to establish the findings in female mice. Results showed that when these mice are given high choline in their diet throughout life, they exhibit improvements in spatial memory, compared with those receiving a normal choline regimen.

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Foods that promote brain function – Tufts

Eat less; move more; live longer is still the mantra here. We want to live as long as possible and also have a fully functioning brain all the way. I consider exercise to be one of the keys, but certainly diet plays a part, too.

Tufts Food & Nutrition Letter says that the science of whether some dietary choices can be considered brain food or not continues to unfold.

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Given long time-frames of conditions such as Alzheimer’s disease and other dementias, it’s challenging to prove any cause and effect relationship between specific foods and brain health. Most such associations are drawn from observational studies, in which people who eat more or less of a certain food are assessed over time for cognitive changes.

It’s obviously difficult to feed a group of study participants lots of, say, blueberries for several years in order to test their brain health at the end; that’s why clinical trials of so-called brain foods have largely depended on animal tests.

Nonetheless, some foods tend to stand out from the pages and pages of research results as most likely being protective for brain health.

Foods That Promote Brain Function

Brain foods typically contain one or more nutrients that scientists believe have positive effects on the brain and/or the cardiovascular system, which in turn affects the brain. These foods include: Continue reading

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Heart Attack Patients with Mild Cognitive Impairment Get Fewer Treatments

I guess this would be an example of the old adage, “When it rains, it pours.”

A new study finds people who have mild cognitive impairment (MCI), which lies on the continuum of cognitive decline between normal cognition and dementia, are less likely to receive proven heart attack treatment in the hospital.

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Researchers found no evidence that those with MCI would derive less benefit from evidence-based treatment that’s offered to their cognitively normal peers who have heart attacks, says lead author Deborah Levine, M.D., MPH.

“Patients should get the treatments they would want if they were properly informed,” says Levine, an associate professor of internal medicine and neurology at Michigan Medicine.

Some people with thinking, memory and language problems have MCI. Unlike dementia, which severely interferes with daily functioning and worsens over time, MCI does not severely interfere with daily functioning and might not worsen over time. Although people with MCI have an increased risk of developing dementia, it’s not an inevitable next step, Levine says.

“While some may progress to dementia, many will persist in having MCI, and a few will actually improve and revert to normal cognition,” says Levine, also a member of the University of Michigan Institute for Healthcare Policy and Innovation. “Many older adults with MCI live years with good quality of life, and so face common health risks of aging like heart attack and stroke.

“Clinicians, patients and families might be overestimating the risk of dementia after a mild cognitive impairment diagnosis even without realizing it. These older adults with MCI should still receive evidence-based treatments when indicated.” Continue reading

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Think declining mental sharpness ‘just comes with age’? Think again, say experts

Declining mental sharpness “just comes with age,” right? Not so fast, say geriatrics researchers and clinicians gathered at a prestigious 2018 conference hosted by the American Geriatrics Society (AGS) with support from the National Institute on Aging (NIA).

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In a report published in the Journal of the American Geriatrics Society (JAGS), attendees of a conference for the NIA’s Grants for Early Medical/Surgical Specialists Transition into Aging Research (GEMSSTAR) program describe how increasing evidence shows age-related diseases–rather than age itself–may be the key cause of cognitive decline. And while old age remains a primary risk factor for cognitive impairment, researchers believe future research–and sustained funding–could illuminate more complex, nuanced connections between cognitive health, overall health, and how we approach age. Continue reading

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10 Brain-saving techniques – Alzheimer’s Association

As regular readers know, I am very sensitive to cognitive impairment, having lost three close family members to Alzheimer’s and dementia. So I was very happy to come across this list of recommendations for building up our mental muscles and reducing our chances of contracting Alzheimer’s from the Alzheimer’s Association.

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“Research on cognitive decline is still evolving,” said Theresa Hocker, president and CEO of the Alzheimer’s Association – North Central Texas Chapter. “But there are actions people can take. Certain healthy behaviors known to combat cancer, cardiovascular disease and diabetes also may reduce the risk of cognitive decline. These include staying mentally active, engaging in regular physical activity, and eating a heart-healthy diet that benefits your body and your brain.”

1. Break a sweat. Engage in regular cardiovascular exercise that elevates your heart rate and increases blood flow to the brain and body. Several studies have found an association between physical activity and reduced risk of cognitive decline.

2. Hit the books. Formal education in any stage of life will help reduce your risk of cognitive decline and dementia. For example, take a class at a local college, community center or online.

3. Butt out. Evidence shows that smoking increases risk of cognitive decline. Quitting smoking can reduce that risk to levels comparable to those who have not smoked. Continue reading

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Left brain vs right brain …

The human brain fascinates me for lots of reasons. I have taken several courses in it from The Great Courses and recommend them for anyone curious about this amazing organ that lives inside our heads. I have written a number of posts on various aspects of the brain which I recommend your chasing down. Just type in b r a i n into the SEARCH BOX at the right. Also, you can check out my Page – Important facts about your brain (and exercise benefits). Last, but not least, of course, there is the specter of dementia in general and Alzheimer’s Disease, in particular. I have lost three family members to these afflictions and, at the age of 79, I am very focused on my mental functions. Which brings us to this wonderful article in Medical News Today on the two hemispheres of the brain – the left and the right.

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The two hemispheres or sides of the brain have slightly different jobs. But can one side be dominant and does this affect personality?

Some people believe that a person is either left-brained or right-brained and that this determines the way they think and behave.

In this article, we explore the truth and fallacy behind this claim. Read on to learn more about the functions and characteristics of the left and right brain. Continue reading

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New blood test for Alzheimer’s – Study

There is possible good news is the study of Alzheimer’s disease. Researchers from Lund University, together with the Roche pharmaceutical company, have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer’s disease. If the method is approved for clinical use, the researchers hope eventually to see it used as a diagnostic tool in primary healthcare. This autumn, they will start a trial in primary healthcare to test the technique.

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Currently, a major support in the diagnostics of Alzheimer’s disease is the identification of abnormal accumulation of the substance beta-amyloid, which can be detected either in a spinal fluid sample or through brain imaging using a PET scanner. Continue reading

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What about teen cannabis use – Study

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About one in five Canadian adolescents uses cannabis (19% of Canadians aged 15-19), and its recent legalization across the country warrants investigation into the consequence of this use on the developing brain. Adolescence is associated with the maturation of cognitive functions, such as working memory, decision-making, and impulsivity control. This is a highly vulnerable period for the development of the brain as it represents a critical period wherein regulatory connection between higher-order regions of the cortex and emotional processing circuits deeper inside the brain are established. It is a period of strong remodeling, making adolescents highly vulnerable to drug-related developmental disturbances. Research presented by Canadian neuroscientists Patricia Conrod, Steven Laviolette, Iris Balodis and Jibran Khokhar at the 2019 Canadian Neuroscience Meeting in Toronto on May 25 featured recent discoveries on the effects of cannabis on the adolescent brain.

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Researchers Define Alzheimer’s-like Brain Disorder

As regular readers know, I have a history of Alzheimer’s Disease or some form of dementia on both sides of my family, so I entertain a strong interest in the subject, particularly since I am a senior citizen.

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A brain disorder that mimics symptoms of Alzheimer’s disease has been defined with recommended diagnostic criteria and guidelines for advancing future research on the condition. Researchers at Rush University Medical Center and scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly named pathway to dementia, limbic-predominant age-related TDP-43 encephalopathy, or LATE, in a report published today in the journal Brain.

“We proposed a new name to increase recognition and research for this common cause of dementia, the symptoms of which mimic Alzheimer’s dementia but is not caused by plaques and tangles (the buildup of beta amyloid proteins that Alzheimer’s produces). Rather, LATE dementia is caused by deposits of a protein called TDP-43 in the brain,” said Dr. Julie Schneider, senior author of the Brain paper and associate director of the Rush Alzheimer’s Disease Center. Continue reading

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Tufts on brain food

The science of whether some dietary choices can be considered brain food or not continues to unfold.

Given long time-frames of conditions such as Alzheimer’s disease and other dementias, it’s challenging to prove any cause and effect relationship between specific foods and brain health. Most such associations are drawn from observational studies, in which people who eat more or less of a certain food are assessed over time for cognitive changes.

berries blackberries blueberries bowls

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It’s obviously difficult to feed a group of study participants lots of, say, blueberries for several years in order to test their brain health at the end; that’s why clinical trials of so-called brain foods have largely depended on animal tests.

Nonetheless, some foods tend to stand out from the pages and pages of research results as most likely being protective for brain health. Continue reading

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Is it possible to supercharge memories back to life? – BU Study

As a 79 year old bike rider, I know how much I am counting on exercise to keep my brain intact as I age. So, I was nothing less than amazed to run across the Boston University (BU) study on electrically stimulating brain function in seniors.

BU brain scientist shows electrostimulation can restore a 70-year-old’s working memory to that of a 20-year-old.

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As you read the words stretched across this page, your brain is doing something magnificent. Each sentence lingers in your mind for a fleeting moment, the letters melding into a symphony of neural signals. These intricate electrical rhythms form the language of the brain, a language we have only begun to understand within the last century.

Rob Reinhart, an assistant professor of psychological and brain sciences at Boston University, says we’ve reached a point where we not only understand this language—we can speak it and harness it to enhance the functioning of the mind. In a groundbreaking study published April 2019 in Nature Neuroscience, Reinhart and BU doctoral researcher John Nguyen demonstrate that electrostimulation can improve the working memory of people in their 70s so that their performance on memory tasks is indistinguishable from that of 20-year-olds.

Reinhart and Nguyen’s research targets working memory—the part of the mind where consciousness lives, the part that is active whenever we make decisions, reason, recall our grocery lists, and (hopefully) remember where we left our keys. Working memory starts to decline in our late 20s and early 30s, Reinhart explains, as certain areas of the brain gradually become disconnected and uncoordinated. By the time we reach our 60s and 70s, these neural circuits have deteriorated enough that many of us experience noticeable cognitive difficulties, even in the absence of dementias like Alzheimer’s disease. Continue reading

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Brain health connects to heart health – CDC

Eat less; move more; live longer is the mantra here. Apparently, it also leads to think better, too. The Centers for Disease Control and Prevention (CDC) seems to think so.

Did you know that the health of your brain and your heart are connected? By keeping your heart healthy, you also lower your risk for brain problems such as stroke and dementia. Learn more about the connection between the heart and brain and steps to take to keep both healthy.

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Heart disease, stroke, and vascular dementia are preventable. Take steps to reduce your risk.

 

  • Control your blood pressure. High blood pressure is a leading cause of heart disease and stroke. Over time, high blood pressure puts too much stress on blood vessels. Scientists now know that having uncontrolled high blood pressure in midlife also raises your risk for dementia later in life. Know your numbers by getting your blood pressure checked regularly. If your blood pressure is high, work with your doctor, nurse, or health care team to manage it. One way to manage your blood pressure is to take your medicines as prescribed. Learn more ways to manage blood pressure.
  • Eat healthy foods and limit alcohol. Eat plenty of vegetables, fruits, whole grains, and low-fat dairy, and include seafood rich in omega-3 fatty acids (such as salmon) each week. Limit foods with added sugars and saturated fats, and lower your sodium (salt) intake. If you drink alcohol, drink in moderation. Drinking too much alcohol raises blood pressure, which can lead to stroke and increase the risk of some kinds of heart disease.
  • Get diabetes under control. Diabetes causes high blood sugar, which can damage blood vessels and nerves. This damage raises the risk for heart disease, stroke, and dementia.
  • Don’t smoke. Smoking damages blood vessels and makes blood more likely to clot, which can lead to heart disease and stroke. Smoking is the leading cause of preventable death in the United States. If you don’t smoke, don’t start. If you do smoke, learn how to quit.
  • Stay active. Lack of physical activity can lead to high blood pressure and obesity. Most Americans don’t meet guidelines of getting at least 150 minutes of moderate-intensity exercise each week. Find ways to get your heart pumping for at least 150 minutes per week. Take the stairs, schedule a walk at lunch, or do jumping jacks during commercial breaks. Learn more about how to get enough physical activity.

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Neuroplasticity – one brainy word

Since I had that nice infographic on the brain yesterday, I thought this one on brain function might be a useful follow-up.

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If you are interested in reading more about that wonderful organ inside your head, feel free to check out my Page – Important facts about your brain (and exercise benefits)

Tony

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Thinking about your brain – infographic

I love this infographic of the brain. Surprisingly, they left out one of the most impressive facts to me, namely, that the brain burns 20 to 25 percent of our daily calories. Bigger than any single muscle.

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Before you go, please check out my Page – Important facts about your brain (and exercise benefits) for a lot more details on this major organ in our body.

Tony

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Physics explains why time flies as we age

Time flies when you’re having fun. As an old timer, I have responded countless times that “Time flies even when you’re not having fun.” So I was most gratified to find this research on exactly that.

A Duke University researcher has a new explanation for why those endless days of childhood seemed to last so much longer than they do now–physics.

According to Adrian Bejan, the J.A. Jones Professor of Mechanical Engineering at Duke, this apparent temporal discrepancy can be blamed on the ever-slowing speed at which images are obtained and processed by the human brain as the body ages.

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The end result is that, because older people are viewing fewer new images in the same amount of actual time, it seems to them as though time is passing more quickly. 

The theory was published online on March 18 in the journal European Review. Continue reading

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Better brain aging through diet – Tufts

I have spent a lot of time writing about the benefits of exercise for the brain as well as the body. Herewith info from the Tufts Health and Nutrition Letter on what I can only call food for thought.

Currently available medical treatments for age-related cognitive decline and Alzheimer’s disease have had limited success. Adopting a healthy diet and lifestyle has been among the most consistent recommendations to maintain brain health over the long term. Some studies have linked an overall healthy dietary pattern to less chance of experiencing age-related decline in memory and other cognitive skills.

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The specifics of “brain protective” diets vary, but tend to have certain elements in common. Dietary patterns associated with lower risk of age-related cognitive decline and dementia are higher in non-starchy vegetables, fruits, whole grains, nuts, legumes and seafood while limited in red and/or processed meats, sugar-sweetened foods and drinks, refined grains and added salt.

But there have been few long-term trials testing overall dietary patterns for protecting the aging brain. Researchers at Rush University Medical Center in Chicago and the Harvard T.H. Chan School of Public Health are currently conducting a clinical trial of a diet specifically optimized for brain health and mild weight loss—the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet.

If successful, the result of the MIND trial will provide older adults with more specific nutritional guidance to maintain their cognitive health. “What they’re doing is logical and I predict will have positive benefits for a disease for which we have few interventions,” notes Dennis Steindler, PhD, senior scientist and director of Tufts’ HNRCA Neuroscience and Aging Laboratory. “Past trials were not home runs, but this study could be it if it bears the kind of findings I think it will.” Continue reading

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