Regular readers know that I have had a number of Alzheimer’s and dementia occurrences in my immediate family. So, I am especially sensitive to anything related to dementia. The following is from Heidi Godman, Exetutive Editor, Harvard Health Letter.
We use the term “dementia” to describe a number of conditions that cause permanent thinking skills changes, such as memory loss and confusion. The most common kind of dementia is Alzheimer’s disease, which is characterized by clumping proteins that get tangled in and around brain cells, eventually causing them to die. The second most common type of dementia is vascular dementia, caused by decreased blood flow to the brain from atherosclerosis—the accumulation of fatty deposits on artery walls.
Once dementia strikes, the damage is permanent, and we don’t have many treatment options. So, before a diagnosis is made, it’s crucial to rule out whether the causes for dementia are actually reversible conditions. Continue reading
Having lost three family members to Alzheimer’s Disease and dementia, I was fascinated by this information from researchers in Berlin.
A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM) and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer’s.
The adenosine receptor belongs to the GPCR family (G Protein-Coupled Receptors), a large group of proteins located in cell membranes, which are key in the transmission of signals and communication between cells. GPCRs are therefore involved in the majority of important physiological processes, including the interpretation of sensory stimuli such as vision, smell, and taste, the regulation of the immune and inflammatory system, and behavior modulation. Continue reading
One of the stated aims of this blog is to live past 100. Posts every day touch on that goal, but mostly in a ‘part of the big picture’ way. Herewith some positive ideas from Harvard Health publications directly on the subject of super-aging.
Finding role models who are older than we are gets more difficult as we age. But in the last few years, medical science has identified a new group we can aspire to join — the super-agers. The term refers to people in their 70s and 80s who have the mental or physical capability of their decades-younger counterparts.
Although super-agers’ brains show less cell loss than those of their contemporaries, their IQs and educational levels are similar. What sets them apart might be that they view problem-solving differently, Dr. Dickerson says. “They may approach these tasks as a challenge they can succeed at, in contrast to typical older adults who may give up.” Continue reading
Some like it hot, but most folks choose sweet or savory ahead of it.
Researchers have found a direct window into the brain systems involved in making every day decisions based on preference.
The study, led by a team of neuroscientists at the University of Glasgow’s Institute of Neuroscience and Psychology, and published in Nature Communications, offers crucial insight into the neural mechanisms underlying our decision-making process, opening up new avenues for the investigation of preference-based choices in humans.
Whether we decide to opt for a piece of apple or a piece of cake is, for example, a preference-based decision. How our brains arrive at such decisions – as well as choices that rely on our subjective valuation of different alternatives – is currently a popular research topic. Continue reading
As I have written in some of my blog posts on the brain. It is our frontal lobes that separate us from the rest of the creatures on this earth. That’s where our conscience resides and our decision-making takes place – our impulse control. It is a fact that the frontal lobes are the last to develop, often times this part of the brain is not developed until the individual reaches age 25. Personally, I found this fact to be an excellent explanation of why I made some of the really dangerous choices I did as a teen. It is well to keep this slow development fact in mind when thinking about freshmen in college living away from home for the first time in their lives.
As students transition from high school to college, they enter a critical period for weight gain. Although eating in a buffet-style dining hall offers freedom and flexibility in food choice, many students cite the abundance of food available as a cause for weight gain. As most college students’ diets are low in fruits and vegetables and high in calories, sugar, fat, and sodium, researchers from the University of Toronto and Memorial University of Newfoundland created a cross-sectional study to examine whether messaging encouraging fruit, vegetable, and water intake could influence the habits of university students.
“Our labeling, focused on beverages and fruits and vegetables, may have been useful to decrease students’ consumption of sugar-sweetened beverages and increase consumption of water, fruits, and vegetables,” said lead author Mary Scourboutakos, PhD, post-doctoral researcher at the University of Toronto. Continue reading
Living past 100 is no walk in the park, although including one can prove very helpful. The American Heart Association has created this list with the goal of improved health by educating the public on how best to live longer and healthier.
These measures have one unique thing in common: any person can make these changes, the steps are not expensive to take and even modest improvements to your health will make a big difference. Start with one or two. This simple, seven step list has been developed to deliver on the hope we all have–to live a long, productive healthy life.
Manage Blood Pressure
High blood pressure is a major risk factor for heart disease and stroke. When your blood pressure stays within healthy ranges, you reduce the strain on your heart, arteries, and kidneys which keeps you healthier longer.
Learn how to manage your blood pressure. Continue reading
Healthy living requires that we make intelligent choices every day. We need to get enough sleep, eat intelligently and exercise regularly. Sleep is one of the underappreciated aspects of living a healthy and long life. Please check out my Page – How important is a good night’s sleep? for more details.
As you sleep, your body is hard at work digesting yesterday’s dinner. By the time you wake up, your body and brain are demanding fresh fuel. “Breaking the fast” is a key way to power up in the morning. Do it right and the benefits can last all day. Continue reading
Moderate-intensity exercise can help improve your thinking and memory in just six months.
Happy days! More positive information on the benefits to the brain garnered from physical exercise! This time from Harvard Medical School.
You probably already know that exercising is necessary to preserve muscle strength, keep your heart strong, maintain a healthy body weight, and stave off chronic diseases such as diabetes. But exercise can also help boost your thinking skills. “There’s a lot of science behind this,” says Dr. Scott McGinnis, an instructor in neurology at Harvard Medical School. Continue reading
Because my family history includes both Alzheimer’s Disease and dementia, I am fascinated by every aspect of the brain and its functions. The following is from Neuroscience News.
The human brain is much better than previously thought at discovering and avoiding disease, a new study led by researchers at Karolinska Institutet in Sweden reports. Our sense of vision and smell alone are enough to make us aware that someone has a disease even before it breaks out. And not only aware – we also act upon the information and avoid sick people. The study is published in the scientific journal Proceedings of the National Academy of Sciences (PNAS).
By injecting harmless sections of bacteria, the researchers activated the immune response in participants, who developed the classic symptoms of disease – tiredness, pain and fever – for a few hours, during which time smell samples were taken from them and they were photographed and filmed. The injected substance then disappeared from their bodies and with it the symptoms. NeuroscienceNews.com image is for illustrative purposes only.
With both Alzheimer’s and dementia in my family, I am interested in all research on the subject.
Tufts reported the following in its Health and Nutrition Letter.
Could a trimmer waistline in middle age help you avoid Alzheimer’s later in life? That’s the suggestion of a study, published in Molecular Psychiatry, from the National Institute on Aging. Researchers analyzed data on 1,394 participants in a long-running study of aging, followed for an average of 14 years, who regularly underwent cognitive testing. A total of 142 participants developed Alzheimer’s disease during the study.
After adjusting for other factors, each additional point of body-mass index (BMI) at age 50 was associated with an earlier onset of Alzheimer’s of 6.7 months. “Our findings clearly indicate that higher adiposity at midlife is associated with a long-lasting effect on accelerating the clinical course of Alzheimer’s disease,” Madhav Thambisetty, MD, PhD, and colleagues concluded.
The study was not designed to prove cause and effect, however, and it’s not clear whether the association between obesity and Alzheimer’s risk might begin even earlier. It’s also true that newly diagnosed Alzheimer’s patients tend to weigh less than normal, not more.
To read further on the subject, please check out my Page – Important facts about your brain – (and exercise benefits).
As a senior citizen, I am aware of the aging process going on in both my body and my brain. I exercise to help preserve both. Here are some super suggestions from Harvard HEALTHbeat on bolstering the memory aspect of your brain.
Your daily habits and lifestyle — what you eat and drink, whether you exercise, how stressed you are, and more — affect your mental health every bit as much as your physical health. A growing body of research indicates that regular exercise and a healthful diet can help protect your memory from aging-related decline. Continue reading
Video games which involve physical activity significantly boost our brain health as we get older, according to new research led by University of Manchester experts.
Study authors Dr Emma Stanmore and Joseph Firth say systems that use physical activity for gaming such as Wii, and Xbox Kinect can boost brain functioning in people with neurological impairment, as well as keeping our minds healthy and active as we age.
In the first ever analysis of all published evidence, the researchers aggregated data from 17 clinical trials examining the effects of active gaming on cognitive functioning across 926 people. Continue reading
The Defense Advanced Research Projects Agency (DARPA) is working with seven U.S. universities and elements of the Air Force and Army on research that seeks to stimulate the brain in a non-invasive way to speed up learning.
DARPA announced the Targeted Neuroplasticity Training, or TNT, program last March, and work now has begun on the effort to discover the safest and most effective ways to activate a natural process called “synaptic plasticity.”
Plasticity is the brain’s ability to strengthen or weaken its neural connections to adapt to changes in the environment. For TNT Program Manager Dr. Doug Weber, such plasticity is about learning.
“We’re talking about neural plasticity, or how the neurons, which are the working units in the brain, how their function changes over time as we train on new skills,” he said during a recent interview with Department of Defense News.
Targeted Neuroplasticity Training
TNT research focuses on a specific kind of learning called cognitive skills training. People use cognitive skills to do things like pay attention, process information, do several things at once, detect and understand patterns, remember instructions, organize information and much more. Continue reading
Having had three family members who suffered from some form of dementia I am highly motivated to find out all I can about this scourge that devastates mostly seniors. The following is from the Rush Alzheimer’s Disease Center.
Genes help cognition withstand damage in brain from Alzheimer’s, Parkinson’s
The pathologies (damage) in the brain that stroke, Alzheimer’s disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it.
Now researchers have discovered two genes, known as UNC5C and ENC1, that are associated with aging individuals having better memory and brain function than would be expected, given the amount of pathologies that accumulated in their brains. They reported their findings in an article published today in the journal PLOS Medicine. Continue reading
There is not necessarily fresh ground broken here, but I think seeing details on how the brain functions can only be helpful. The most important idea for me is one I had going in, namely, you only have one brain so take care of it.
Like air-traffic controllers scrambling to reconnect flights when a major hub goes down, the brain has a remarkable ability to rewire itself after suffering an injury. However, maintaining these new connections between brain regions can strain the brain’s resources, which can lead to serious problems later, including Alzheimer’s Disease, according to researchers.
After a head injury, the brain can show enhanced connectivity by using alternative routes between two previously connected regions of the brain that need to communicate, as well as make stronger connections, said Frank G. Hillary, associate professor of psychology, Penn State. These new connections between damaged areas are often referred to as hyperconnections, he added. Continue reading
Eat less; move more; live longer is the mantra of this blog. Seems that a healthy lifestyle increases the chances of a healthy brain as we age, according to the Mayo Clinic.
Adopting a healthy lifestyle can protect the brain against several risk factors for Alzheimer’s disease, Mayo Clinic research shows. Controlling blood pressure and cholesterol and avoiding obesity, smoking and diabetes are among the steps that can help preserve brain health, according to the study, published in JAMA Neurology.
Neurologists believe two aspects make up Alzheimer’s disease:
- Amyloid deposits: Toxic proteins that build up plaques on the brain.
- Neurodegeneration: Loss of structure and function of neurons in the brain.
The Mayo research examined whether the risk factors and protective steps against each differ. Continue reading