Tag Archives: aging

Intelligent brains take longer to solve difficult problems

Do intelligent people think faster? Researchers at the BIH and Charité – Universitätsmedizin Berlin, together with a colleague from Barcelona, made the surprising finding that participants with higher intelligence scores were only quicker when tackling simple tasks, while they took longer to solve difficult problems than subjects with lower IQ scores. In personalized brain simulations of the 650 participants, the researchers could determine that brains with reduced synchrony between brain areas literally “jump to conclusions” when making decisions, rather than waiting until upstream brain regions could complete the processing steps needed to solve the problem. In fact, the brain models for higher score participants also needed more time to solve challenging tasks but made fewer errors. The scientists have now published their findings in the journal Nature Communications.

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There are 100 billion or so neurons in the human brain. Each one of them is connected to an estimated 1,000 neighboring or distant neurons. This unfathomable network is the key to the brain’s amazing capabilities, but it is also what makes it so difficult to understand how the brain works.

Prof. Petra Ritter, head of the Brain Simulation Section at the Berlin Institute of Health at Charité (BIH) and at the Department of Neurology and Experimental Neurology of Charité – Universitätsmedizin Berlin, simulates the human brain using computers. “We want to understand how the brain’s decision-making processes work and why different people make different decisions,” she says, describing the current project.

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Artificial intelligence identifies anti-aging drug candidates targeting ‘zombie’ cells

new publication in the May issue of Nature Aging by researchers from Integrated Biosciences, a biotechnology company combining synthetic biology and machine learning to target aging, demonstrates the power of artificial intelligence (AI) to discover novel senolytic compounds, a class of small molecules under intense study for their ability to suppress age-related processes such as fibrosis, inflammation and cancer. The paper,“Discovering small-molecule senolytics with deep neural networks,” authored in collaboration with researchers from the Massachusetts Institute of Technology (MIT) and the Broad Institute of MIT and Harvard, describes the AI-guided screening of more than 800,000 compounds to reveal three drug candidates with comparable efficacy and superior medicinal chemistry properties than those of senolytics currently under investigation.

Senolytics are an emerging class of investigational drug compounds that selectively kill aging-associated senescent cells (left, with red stain) without affecting other cells (right). Using artificial intelligence, researchers from Integrated Biosciences have, for the first time, identified three senolytics with comparable efficacy and superior drug-like properties relative to leading investigational compounds.

“This research result is a significant milestone for both longevity research and the application of artificial intelligence to drug discovery,” said Felix Wong, Ph.D., co-founder of Integrated Biosciences and first author of the publication. “These data demonstrate that we can explore chemical space in silico and emerge with multiple candidate anti-aging compounds that are more likely to succeed in the clinic, compared to even the most promising examples of their kind being studied today.”

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Biological age is increased by stress and restored upon recovery

The biological age of humans and mice undergoes a rapid increase in response to diverse forms of stress, which is reversed following recovery from stress, according to a study publishing on April 21 in the journal Cell Metabolism. These changes occur over relatively short time periods of days or months, according to multiple independent epigenetic aging clocks.

“This finding of fluid, fluctuating, malleable age challenges the longstanding conception of a unidirectional upward trajectory of biological age over the life course,” says co-senior study author James White of Duke University School of Medicine. “Previous reports have hinted at the possibility of short-term fluctuations in biological age, but the question of whether such changes are reversible has, until now, remained unexplored. Critically, the triggers of such changes were also unknown.”

The biological age of organisms is thought to steadily increase over the life course, but it is now clear that biological age is not indelibly linked to chronological age. Individuals can be biologically older or younger than their chronological age implies. Moreover, increasing evidence in animal models and humans indicates that biological age can be influenced by disease, drug treatment, lifestyle changes, and environmental exposures, among other factors.

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Indigenous populations and brain-aging

Among Indigenous, rural non-industrial populations inhabiting the tropical forests of lowland Bolivia, researchers report, there appears to be an optimal balance between levels of food consumption and exercise that maximizes healthy brain aging and reduces the risk of disease.

“We hypothesize that energy gain from food intake was positively associated with late life brain health in the physically active, food-limited world of our ancestors, but that obesity and other manifestations of a Western lifestyle now lead to greater cognitive aging and dementia in middle and older ages,” said UC Santa Barbara professor of anthropology Michael Gurven, a senior co-author on a study that published in the Proceedings of the National Academy of Sciences.

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For this paper, the researchers collaborated with the Tsimané and Mosetén tribes, two Indigenous populations that live along tributaries of the Amazon River that flow through lowland Bolivia. In comparison to urban post-industrialized populations, these groups have less reliable access to food and have to exert a lot of effort to get it. They also have less access to modern health care. Meanwhile, people in wealthy countries have largely grown accustomed to eating more and exercising less — habits that are associated with decreased brain volumes and faster cognitive decline.

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Sense of smell linked to speed of brain loss and cognitive decline – NIA

Having a good sense of smell is associated with slower loss of brain volume and cognitive decline in older adults, and the link between sense of smell and brain and cognitive changes may be especially pronounced among those who develop cognitive impairment or dementia. These are the key findings from NIA-led research published recently in Neurology.

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The sense of smell declines with age, and loss of olfactory function is also an early symptom of neurodegenerative diseases such as Parkinson’s and Alzheimer’s. While previous research found the sense of smell was associated with brain volume and function, no studies had examined longitudinal changes within an individual across the whole brain and by cognitive status.

In this study, scientists analyzed sense of smell, brain imaging, and cognitive performance data from participants in the NIA Baltimore Longitudinal Study of Aging. The researchers examined whether sense of smell, as reflected by odor identification scores, was associated with longitudinal changes in regional brain volumes and changes to cognitive function. To examine the association between sense of smell and brain volume, they compared odor identification scores and brain MRI scans from a subset of 567 participants. The association between sense of smell and cognitive function was analyzed by comparing odor identification scores and cognitive evaluations from a subset of 754 participants. The subsets were analyzed separately but included 565 overlapping participants with both brain MRI scans and cognitive assessment data.

Participants who developed cognitive impairment or dementia had worse odor identification scores than those who did not. Better odor identification scores were associated with slower loss of brain volume, particularly in the frontal and temporal regions — areas important for thinking and memory. Better scores were also associated with slower decline in memory, attention, processing speed, and sensorimotor integration skills over time. However, when data points after a diagnosis of cognitive impairment or dementia were excluded from analysis, the associations between sense of smell with brain volume and cognitive functioning were not as strong.

These study findings add to evidence that sense of smell is related to cognitive impairment and dementia and demonstrate longitudinal relationships with brain volume loss in specific brain areas and cognitive decline in specific domains. Future studies with longer follow-ups of change over time may help researchers better understand the potential for using sense of smell as an early biomarker of cognitive decline and the role of specific brain regions in this association.

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Boosting the body’s anti-viral immune response may eliminate aging cells

Aging, or senescent cells, which stop dividing but don’t die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

In mice, eliminating senescent cells from aging tissues can restore tissue balance and lead to an increased healthy lifespan. Now a team led by investigators at Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB), has found that the immune response to a virus that is ubiquitously present in human tissues can detect and eliminate senescent cells in the skin.



For the study, which is published in Cell, the scientists analyzed young and old human skin samples to learn more about the clearance of senescent cells in human tissue.

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The researchers found more senescent cells in the old skin compared with young skin samples. However, in the samples from old individuals, the number of senescent cells did not increase as individuals got progressively older, suggesting that some type of mechanism kicks in to keep them in check.

Experiments suggested that once a person becomes elderly, certain immune cells called killer CD4+ T cells are responsible for keeping senescent cells from increasing. Indeed, higher numbers of killer CD4+ T cells in tissue samples were associated with reduced numbers of senescent cells in old skin.

When they assessed how killer CD4+ T cells keep senescent cells in check, the researchers found that aging skin cells express a protein, or antigen, produced by human cytomegalovirus, a pervasive herpesvirus that establishes lifelong latent infection in most humans without any symptoms. By expressing this protein, senescent cells become targets for attack by killer CD4+ T cells.

“Our study has revealed that immune responses to human cytomegalovirus contribute to maintaining the balance of aging organs,” says senior author Shawn Demehri, MD, PhD, director of the High Risk Skin Cancer Clinic at MGH and an associate professor of Dermatology at Harvard Medical School. “Most of us are infected with human cytomegalovirus, and our immune system has evolved to eliminate cells, including senescent cells, that upregulate the expression of cytomegalovirus antigens.”

These findings, which highlight a beneficial function of viruses living in our body, could have a variety of clinical applications. “Our research enables a new therapeutic approach to eliminate aging cells by boosting the anti-viral immune response,” says Demehri. “We are interested in utilizing the immune response to cytomegalovirus as a therapy to eliminate senescent cells in diseases like cancer, fibrosis and degenerative diseases.”

Demehri notes that the work may also lead to advances in cosmetic dermatology, for example in the development of new treatments to make skin look younger.

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Shining light on aging hearts

Light therapy has demonstrated its usefulness in treating a variety of diseases. But can it delay the occurrence of age-related disease?

The answer may be yes, according to a study in mice published in February in Lasers in Surgery and Medicine. Praveen Arany, a University at Buffalo expert in a form of light therapy called photobiomodulation (PBM), was co-principal investigator with Edward G. Lakatta, MD, of the National Institute on Aging, which is part of the National Institutes of Health.

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Almost 20% of Americans older than 65 have been diagnosed with heart disease, and heart disease continues to be the leading cause of death in the United States. “The idea was to see if intervention in middle age could enable people to avoid further age-related heart deterioration,” said Arany, PhD, DDS, associate professor of oral biology in UB School of Dental Medicine.

The study focused on heart condition and function in middle-aged mice, 14 months of age. The research showed an improvement in heart function after exposure to PBM therapy. PBM also mitigated the thickness of the cardiac wall. “As muscle thickens, it becomes stiffer, and the pumping action of the heart is less effective,” said Arany. Gait symmetry — observing how mice performed comfortably on a treadmill — also improved, suggesting an improvement in neuromuscular coordination.

The experiment exposed mice to a dose of near-infrared light by using an overhead LED light source rather than a focused light source. The ambient low-dose exposure took place five days a week for two minutes each day. One group of the genetically manipulated mice gets severe heart disease, which usually causes death. After treatment with PBM, heart disease among these mice with heart disease did not progress. The survival rate among the most susceptible group was 100%, compared to the usual survival rate of 43%. The results were significant even though the eight-month study was interrupted for three months by COVID-19.

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Healthy Longevity – Harvard

Longevity is the achievement of a long life. We may hope for longevity so that we can experience many years of quality time with loved ones or have time to explore the world. But living to a ripe old age doesn’t necessarily mean healthy or happy longevity if it is burdened by disability or disease. The population of people over age 65 has grown more quickly than other age groups due to longer life spans and declining birth rates, and yet people are living more years in poor health. Therefore, we will explore not just one’s lifespan but healthspan, which promotes more healthy years of life according to Harvard School of Public Health.

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What you do today can transform your healthspan or how you age in the future. Although starting early is ideal, it’s never too late to reap benefits.

Five factors for a longer and healthier lifespan

  1. Healthy diet – The prevalence of hypertension (high blood pressure) and dementia increases with age. Eating patterns such as those from the DASH, MIND, and Mediterranean diets can lower the risk of these and other chronic conditions that accompany older ages.
  2. Regular exercise – Regular physical activity lowers the risk of several chronic conditions that increase with age including heart disease, hypertension, diabetes, osteoporosis, certain cancers, and cognitive decline. Exercise also helps to lower anxiety and blood pressure, and improve sleep quality. The Physical Activity Guidelines for Americans from the U.S. Department of Health and Human Services first recommends to move more and sit less, with some activity better than none. For additional health benefits, they advise a minimum of 150-300 minutes weekly of moderate to vigorous activity, like brisk walking or fast dancing, as well as two days a week of muscle-strengthening exercises. Older adults who are at risk for falls may also wish to include balance training such as tai chi or yoga. See additional physical activity considerations for older adults
  3. Healthy weight – Determining one’s healthy weight range is unique for each person. Factors to consider include reviewing current health conditions, family history, weight history, and genetically inherited body type. Rather than focusing on scale weight alone, monitoring an increase in harmful visceral “belly fat” and weight change since age 20 may be useful.
  4. Not smoking – Smoking is a strong risk factor for cancer, diabetes, cardiovascular disease, lung diseases, and earlier death as it promotes chronic inflammation and oxidative stress (a condition that can damage cells and tissues). [2] Smoking harms nearly every organ of the body. Quitting greatly reduces the risk of these smoking-related diseases. [4]
  5. Moderate alcohol – Research finds that moderate drinking, defined as 1 drink daily for women and 2 drinks daily for men, is associated with lower risk of type 2 diabetes, heart attacks, and early death from cardiovascular disease. Low to moderate amounts of alcohol raises levels of “good” cholesterol or high-density lipoprotein (HDL) and prevent small blood clots that can block arteries. However, because alcohol intake—especially heavier drinking—is also associated with risks of addiction, liver disease, and several types of cancer, it is a complex issue that is best discussed with your physician to weigh your personal risk versus benefit.

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To Ward Off Aging, Stem Cells Must Take Out the Trash

In humanity’s ongoing quest for the elixir of life, the science keeps pointing to stem cells. Research increasingly shows that maintaining stem cell fitness promotes a long healthspan, and new findings show keeping stem cells clean and tidy is an integral step.

In a study published March 21, 2023 in Cell Stem Cell, researchers at University of California San Diego School of Medicine found that blood stem cells use an unexpected method to get rid of their misfolded proteins, and that this pathway’s activity degrades with age. The authors say boosting this specialized garbage disposal system could help protect against age-related diseases.

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The study focused on hematopoietic stem cells (HSCs), the cells in our bone marrow that produce new blood and immune cells throughout our lives. When their function is weakened or lost, this can lead to blood and immune disorders, such as anemia, blood clotting and cancer.

“Stem cells are in it for the long haul,” said senior study author Robert Signer, PhD, associate professor at UC San Diego School of Medicine. “Their need for longevity requires them to be wired differently than all the short-lived cells in the body.”

A key to keeping stem cells happy is maintaining protein homeostasis. Previous work showed that stem cells, including HSCs, synthesize proteins much slower than other cell types, prioritizing quality over quantity. This helps them make fewer mistakes in the process, as misfolded proteins can become toxic to cells if allowed to build up.

Still, some mistakes or protein damage are inevitable, so the researchers set out to understand how stem cells ensure these proteins are properly discarded.

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For clues to healthy brain aging, look to the Bolivian Amazon

Some of the lowest rates of heart and brain disease ever reported by science are found among Indigenous communities inhabiting the tropical forests of lowland Bolivia. New USC research on two of these societies, the Tsimané and Mosetén, suggests that there are optimal levels of food consumption and exercise that maximize healthy brain aging and reduce the risk of disease.

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The study appears on Monday, March 20 in Proceedings of the National Academy of Sciences.

Thanks to industrialization, humans now enjoy greater access to food, less physical toil and better access to health care than ever before. However, we’ve grown accustomed to eating more and exercising less. Obesity and sedentary lifestyles are associated with smaller brain volumes and faster cognitive decline.

To better understand the tipping point where abundance and ease begin to undermine health, the researchers enrolled 1,165 Tsimané and Mosetén adults, aged 40-94 years, and provided transportation for participants from their remote villages to the closest hospital with CT scanning equipment.

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Excess weight, obesity more deadly than previously believed – Study

Excess weight or obesity boosts risk of death by anywhere from 22% to 91%—significantly more than previously believed—while the mortality risk of being slightly underweight has likely been overestimated, according to new CU Boulder research.

The findings, published Feb. 9 in the journal Population Studies, counter prevailing wisdom that excess weight boosts mortality risk only in extreme cases. 

The statistical analysis of nearly 18,000 people also shines a light on the pitfalls of using body mass index (BMI) to study health outcomes, providing evidence that the go-to metric can potentially bias findings. After accounting for those biases, it estimates that about 1 in 6 U.S. deaths is related to excess weight or obesity.

“Existing studies have likely underestimated the mortality consequences of living in a country where cheap, unhealthy food has grown increasingly accessible, and sedentary lifestyles have become the norm,” said author Ryan Masters, associate professor of sociology at CU Boulder.

“This study and others are beginning to expose the true toll of this public health crisis.” 

Challenging the obesity paradox

While numerous studies show that heart disease, high blood pressure and diabetes (which are often associated with being overweight) elevate mortality risk, very few have shown that groups with higher BMIs have higher mortality rates.

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Reducing trip hazards and decluttering can prevent falls among older people living at home

Eliminating hazards around the home, such as clutter, stairs without railings and poor lighting, can reduce the risk of falls for older people by around a quarter, according to a new Cochrane review.

The review did not find any compelling evidence for other measures to reduce falls, such as making sure older people have the correct prescription glasses, special footwear, or education on avoiding falls.

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It also found that decluttering and reducing hazards had the most benefit for older people who are at risk of falls, for example because they have recently had a fall and been hospitalised or need support with daily activities such as dressing or using stairs.

Nearly one third of people aged 65 years and older fall each year. Most falls occur in the home.

Lindy Clemson, Professor Emeritus at the University of Sydney, Australia was lead author of the review. She said: “Falls are very common among older people. They can cause serious injury or even death, but they are preventable. In this review we wanted to examine which measures could have the biggest impact on reducing falls among older people living at home.”

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Fresh understanding of aging in the brain offers hope for treating neurological diseases

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on aging processes in the brain. By linking the increased presence of specialized immune cells to conditions such as Alzheimer’s disease and traumatic brain injury for the first time, they have unearthed a possible new target for therapies aimed at treating age-related neurological diseases.

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The research, which benefited from a collaboration with experts at the University of Maryland School of Medicine and focused on microglia in the brain and spinal cord, is published in leading international journal, Science Advances.

Microglia are a unique type of immune cell whose job it is to support nerve cells, defend against invading microbes, clear debris and remove dying nerve cells by engulfing and eating them. Emerging research indicates that microglia can have different functional responses depending on molecular and biochemical changes occurring within these specialized cells. 

In fact, various subtypes of microglia can be distinguished based on a property called autofluorescence. This is the tendency of cells to emit light of one color after they have absorbed light of another, and it occurs because specific substances inside the cells absorb light. The substances stored in specialized cellular compartments include fat molecules, cholesterol crystals, metals and other misfolded proteins. 

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Alzheimer’s study links cholesterol and toxic protein clusters

Cholesterol tremendously increases the toxicity of a peptide implicated in Alzheimer’s progression, according to research by scientists in the Department of Biochemistry and Biophysics in Texas A&M’s College of Agriculture and Life Sciences.

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The study, “Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1-42 aggregates,” by Dmitry Kurouski, Ph.D., and research assistants Kiryl Zhaliazka and Mikhail Matyeyenka, was supported by a $1.5 million Maximizing Investigators’ Research Award from the National Institutes of Health. It was published in FEBS Journal — the journal of the Federation of European Biochemical Societies.

“The study found that certain lipids can increase the toxicity of amyloid beta peptides, which are thought to play a role in the development of Alzheimer’s disease,” said Kurouski, an assistant professor and primary investigator for the study, Bryan-College Station. “Specifically, we discovered that the interaction between amyloid beta and lipids can cause the formation of small, toxic clusters called oligomers.”

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Daily 11 minute brisk walk enough to reduce risk of early death – Cambridge

One in ten early deaths could be prevented if everyone managed at least half the recommended level of physical activity, say a team led by researchers at the University of Cambridge.

In a study published today in the British Journal of Sports Medicine, the researchers say that 11 minutes a day (75 minutes a week) of moderate-intensity physical activity – such as a brisk walk – would be sufficient to lower the risk of diseases such as heart disease, stroke and a number of cancers.

Cardiovascular diseases – such as heart disease and stroke – are the leading cause of death globally, responsible for 17.9 million deaths per year in 2019, while cancers were responsible for 9.6 million deaths in 2017. Physical activity – particularly when it is moderate-intensity – is known to reduce the risk of cardiovascular disease and cancer, and the NHS recommends that adults do at least 150 minutes of moderate-intensity activity or 75 minutes of vigorous-intensity activity a week.

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To explore the amount of physical activity necessary to have a beneficial impact on several chronic diseases and premature death, researchers from the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge carried out a systematic review and meta-analysis, pooling and analyzing cohort data from all of the published evidence. This approach allowed them to bring together studies that on their own did not provide sufficient evidence and sometimes disagreed with each other to provide more robust conclusions.

In total, they looked at results reported in 196 peer-reviewed articles, covering more than 30 million participants from 94 large study cohorts, to produce the largest analysis to date of the association between physical activity levels and risk of heart disease, cancer, and early death.

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Study of green tea and other molecules uncovers new therapeutic strategy for Alzheimer’s

Researchers have discovered how a molecule found in green tea breaks apart tangles of the protein tau, a hallmark of Alzheimer’s disease. Based on this finding, the team identified other molecules that can also untangle tau and may be better drug candidates than the green tea molecule. Results from the NIA-funded study, published in Nature Communications, suggest that this approach may one day provide an effective strategy for treating Alzheimer’s.

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In Alzheimer’s, tau abnormally sticks together in fibrous tangles that spread between brain cells, leading to cell death. The molecule epigallocatechin gallate (EGCG) — the one found in green tea — is known to untangle these tau fibers. However, EGCG is not on its own an effective Alzheimer’s treatment because it cannot easily penetrate the brain and binds to many proteins other than tau, weakening its effect. Therefore, researchers wanted to find molecules that replicate the effects of EGCG but have better drug properties for treating Alzheimer’s.

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