Tag Archives: aging

Frailty: Rising global health burden for an aging society

Eat less; move more; live longer. Also, if you keep moving and using those muscles,  you will reduce your chances of suffering from frailty as you age.

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Despite the evidence on risk factors for frailty, and the substantial progress that has been made in frailty awareness, the biological mechanisms underlying its development are still far from understood and translation from research to clinical practice remains a challenge, according to a new series on Frailty just published by The Lancet. Linda P. Fried, MD, MPH, dean of Columbia University Mailman School of Public Health and DeLamar Professor of Public Health Practice, and Professor of Epidemiology and Medicine, was part of an international group of experts who contributed to the series of papers which provide an up-to-date clinical overview on preventing, identifying and managing frailty as well as its global impact and burden. The series also offers evidence-based interventions for individuals with frailty. The findings are published online.

In the paper on Clinical Practice and Public Health, Fried, a renowned gerontologist and expert on aging, highlights two emerging lines of life course evidence on frailty. First, Fried and colleagues make the point that the risk of adverse outcomes can be predicted. Secondly, there is a clinical syndrome of frailty which is an outcome of biologic aging, although risk levels are substantially higher among those with certain diagnoses and comorbidities. She also notes that while great strides have been made in understanding frailty in the past two decades, many gaps in knowledge remain: no universal consensus exists on the definition of frailty or its assessment, and more robust, high-quality trials of strategies to prevent and manage frailty are needed.

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Exercise benefits your heart, despite your age …

Eat less; move more; live longer – no matter how old you are. Yes, the mantra of this blog applies to all of us, especially the old and out of shape …

A new study in the Canadian Journal of Cardiology showed that older individuals have the most to gain and may gain the most from rehabilitation programs, but this need is often ignored.

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Regular exercise is highly beneficial for all patients with cardiovascular disease regardless of age, report investigators in the Canadian Journal of Cardiology, published by Elsevier. Their results showed that the patients who benefited most from cardiac rehabilitation were those who started out with the greatest physical impairment. Continue reading

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Common nutrient supplementation may hold the answers to combating Alzheimer’s disease -Study

Everyone knows that there is no cure for Alzheimer’s Disease. One of the problems is that by the time  that symptoms become apparent, the disease has progressed so far as to be irreversible. This new study, however, appears to offer the chance of heading off the disease before it gets out of hand.

In a new study, Biodesign researchers reveal that a lifelong dietary regimen of choline holds the potential to prevent Alzheimer’s disease (AD).

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Choline is a safe and easy-to-administer nutrient that is naturally present in some foods and can be used as a dietary supplement. Lead author Ramon Velazquez and his colleagues at the ASU-Banner Neurodegenerative Disease Research Center (NDRC) looked into whether this nutrient could alleviate the effects of Alzheimer’s.

Earlier this year, Velazquez and colleagues found transgenerational benefits of AD-like symptoms in mice whose mothers were supplemented with choline. The latest work expands this line of research by exploring the effects of choline administered in adulthood rather than in fetal mice.

The study focuses on female mice bred to develop AD-like symptoms. Given the higher prevalence of AD in human females, the study sought to establish the findings in female mice. Results showed that when these mice are given high choline in their diet throughout life, they exhibit improvements in spatial memory, compared with those receiving a normal choline regimen.

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Harvard on resuming bike riding

I know that we are late in September and a lot of folks will be putting away their bikes ‘for the season.’ I ride year ’round here in Chicago and enjoy it. If you are one of those who haven’t ridden in a while and would like to take up a super form of exercise, I hope you will consider cycling. There are still a few good weeks left before the cold sets in. You can get started now.

The Harvard Health Publications has a nice positive blog post on starting cycling again presumably as a senior.

Heidi Godman, Executive Editor of the Harvard Health Letter, states that she loved riding as a kid, but now only rides occasionally.

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“It’s fun, it’s socially oriented, and it gets you outside and exercising,” says Dr. Clare Safran-Norton, a physical therapist at Harvard-affiliated Brigham and Women’s Hospital. Plus, cycling is an aerobic activity, it’s easy on the joints, and it helps build muscle and bone. Continue reading

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Writing into old age!

I have written repeatedly about how exercise benefits the brain as well as the body. Here is a wonderful post about exercising the ‘old noodle’ and how it has direct benefits on the brain.

Learning from Dogs

Thank goodness for this!

It’s not exactly a ball of fun growing old. But while somethings inevitable decline writing isn’t one of them. This is a fascinating article from The Conversation.

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One skill that doesn’t deteriorate with age

Reading and writing can prevent cognitive decline.
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Roger J. Kreuz, University of Memphis

When Toni Morrison died on Aug. 5, the world lost one of its most influential literary voices.

But Morrison wasn’t a literary wunderkind. “The Bluest Eye,” Morrison’s first novel, wasn’t published until she was 39. And her last, “God Help the Child,” appeared when she was 84. Morrison published four novels, four children’s books, many essays and other works of nonfiction after the age of 70.

Morrison isn’t unique in this regard. Numerous writers produce significant work well into their 70s, 80s and even their 90s. Herman Wouk, for example, was 97…

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Heart Attack Patients with Mild Cognitive Impairment Get Fewer Treatments

I guess this would be an example of the old adage, “When it rains, it pours.”

A new study finds people who have mild cognitive impairment (MCI), which lies on the continuum of cognitive decline between normal cognition and dementia, are less likely to receive proven heart attack treatment in the hospital.

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Researchers found no evidence that those with MCI would derive less benefit from evidence-based treatment that’s offered to their cognitively normal peers who have heart attacks, says lead author Deborah Levine, M.D., MPH.

“Patients should get the treatments they would want if they were properly informed,” says Levine, an associate professor of internal medicine and neurology at Michigan Medicine.

Some people with thinking, memory and language problems have MCI. Unlike dementia, which severely interferes with daily functioning and worsens over time, MCI does not severely interfere with daily functioning and might not worsen over time. Although people with MCI have an increased risk of developing dementia, it’s not an inevitable next step, Levine says.

“While some may progress to dementia, many will persist in having MCI, and a few will actually improve and revert to normal cognition,” says Levine, also a member of the University of Michigan Institute for Healthcare Policy and Innovation. “Many older adults with MCI live years with good quality of life, and so face common health risks of aging like heart attack and stroke.

“Clinicians, patients and families might be overestimating the risk of dementia after a mild cognitive impairment diagnosis even without realizing it. These older adults with MCI should still receive evidence-based treatments when indicated.” Continue reading

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Think declining mental sharpness ‘just comes with age’? Think again, say experts

Declining mental sharpness “just comes with age,” right? Not so fast, say geriatrics researchers and clinicians gathered at a prestigious 2018 conference hosted by the American Geriatrics Society (AGS) with support from the National Institute on Aging (NIA).

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In a report published in the Journal of the American Geriatrics Society (JAGS), attendees of a conference for the NIA’s Grants for Early Medical/Surgical Specialists Transition into Aging Research (GEMSSTAR) program describe how increasing evidence shows age-related diseases–rather than age itself–may be the key cause of cognitive decline. And while old age remains a primary risk factor for cognitive impairment, researchers believe future research–and sustained funding–could illuminate more complex, nuanced connections between cognitive health, overall health, and how we approach age. Continue reading

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Myths about high blood pressure – Rush

Blood pressure is like what Mark Twain said about the weather, “Everybody talks about it, but nobody does anything about it.” Well almost. I have found that blood pressure is one of those subjects that is widely and wildly misunderstood. I used to think it was like grey hair on old people. Everybody has it. I was dead wrong.

Few assumptions are more dangerous than this one: If you have high blood pressure, you know it.

Doctors refer to high blood pressure, or hypertension, as a silent killer because it rarely produces warning signs.

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“When symptoms do occur, such as headache, nosebleeds or blurry vision, high blood pressure may have already reached severe and possibly life-threatening levels,” says Daniel Pohlman, MD, a primary care doctor at Rush University Medical Center. Continue reading

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Aging arteries weaken memory – Study

Regular readers know of my concern about aging and its effect on cognition as three of my direct family members suffered from Alzheimer’s Disease and dementia. For that reason I try to keep my arteries flexible through my program of regular exercise. I know that there is no known way to prevent Alzheimer’s, but I am willing to take any physical measures that I can to reduce my chances. Check out my Page  – Important facts about your brain (and exercise benefits) for more details on this subject.

Researchers in Umeå, Sweden, have presented a model that explains why memory deteriorates as the body ages. With age, the brain receives an increased load from the heart’s beating as the body’s large arteries stiffen over the years, causing damage to the smallest blood vessels in the brain.

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The fact that human memory is deteriorating with increasing age is something that most people experience sooner or later, even among those who avoid diseases such as Alzheimer’s. Similarly, a connection between the ageing of the brain and the body is well known. However, the exact nature of this association is not known.

“We suggest a chain of events on how the aging of the brain and vessels are related,” says Lars Nyberg, professor at Umeå University.

What Umeå researchers Lars Nyberg and Anders Wåhlin have created is an explanatory model that starts with the heartbeat, and carries through the largest arteries in the body all the way to the finest vessels in the brain. An important feature of the model is that it provides a rationale why some cognitive processes may be particularly at risk for the proposed mechanism.

As the human body ages, large arteries, such as the aorta, stiffen and lose a large portion of their ability to absorb the pressure increase generated as the heart ejects blood into the arteries. Such pressure pulsatility is instead transmitted to smaller blood vessels, for example those in the brain. The smallest blood vessels in the brain, the capillaries, are subjected to an increased stress that causes damage to cells within and surrounding the capillary walls. These cells are important in the regulation of the capillary blood flow. If the smallest blood vessels are damaged, this is detrimental to the ability to increase the blood supply to the brain when coping with demanding cognitive processes.

According to the researchers’ model, the hippocampus in the brain is particularly vulnerable. The structure in that part of the brain is important for the episodic memory, that is, the ability to remember events from the past. The vulnerability of the hippocampus relates to the fact that it is located close to the large vessels and thus is exposed to the increased load early in the chain. In a young and healthy person, the pulsations are soft, but in an ageing person the pulsations can be so powerful that they affect the brain tissue and can damage the blood supply to memory processes.

The Umeå researchers’ model is based on a number of previous studies from the last five years.

“We have laid the puzzle of current and verified research in different fields to a broader and more detailed picture of the course of events. It will form a starting point for future research to gain a better understanding and, in the long term, researchers may also find solutions to slow down the process,” says Anders Wåhlin.

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10 Brain-saving techniques – Alzheimer’s Association

As regular readers know, I am very sensitive to cognitive impairment, having lost three close family members to Alzheimer’s and dementia. So I was very happy to come across this list of recommendations for building up our mental muscles and reducing our chances of contracting Alzheimer’s from the Alzheimer’s Association.

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“Research on cognitive decline is still evolving,” said Theresa Hocker, president and CEO of the Alzheimer’s Association – North Central Texas Chapter. “But there are actions people can take. Certain healthy behaviors known to combat cancer, cardiovascular disease and diabetes also may reduce the risk of cognitive decline. These include staying mentally active, engaging in regular physical activity, and eating a heart-healthy diet that benefits your body and your brain.”

1. Break a sweat. Engage in regular cardiovascular exercise that elevates your heart rate and increases blood flow to the brain and body. Several studies have found an association between physical activity and reduced risk of cognitive decline.

2. Hit the books. Formal education in any stage of life will help reduce your risk of cognitive decline and dementia. For example, take a class at a local college, community center or online.

3. Butt out. Evidence shows that smoking increases risk of cognitive decline. Quitting smoking can reduce that risk to levels comparable to those who have not smoked. Continue reading

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Is Cycling Past 70 Different Than Cycling Past 50?

I wanted to reblog this because I ran it six years ago and it seems unlikely that a lot of you are familiar with it. Also, there are some great ideas inside. Enjoy!

One Regular Guy Writing about Food, Exercise and Living Past 100

I ran across this excellent discussion of senior cycling on RoadBikeRider.com. They have graciously permitted me to reprint it. See permission at end.

RBR Editor’s Note: Coach John Hughes copied me on a recent email exchange he had with Marty Hoganson, an RBR reader with whom he had ridden on tours in years gone by. Marty wondered what, if any, differences there are in terms of recovery, motivation, etc., between 50-somethings and 70-somethings. Both agreed to let me share the exchange with RBR readers. It provides a wealth of solid, useful information.

Marty Asked:
These days I live and ride in Yuma, Arizona. I am involved in our local bike club called Foothills Bicycle Club, which is primarily made up of retired folks – late-50s to mid-80s. Many strong riders in their 60s and 70s, for their ages — or any age, for that matter.

Now that I am older…

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Diets rich in blueberries yield diverse benefits

A collection of new studies in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences further quantifies how blueberry consumption can contribute to healthy aging.

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“Since the 1990s, research on the health benefits of blueberries has grown exponentially,” wrote guest editor Donald K. Ingram, PhD, FGSA, in an opening editorial. “Studies have documented that this fruit ranks highest in antioxidant activity compared to many other popular fruits. Moreover, other mechanisms for the health benefits of blueberries, such as their anti-inflammatory properties, have been identified.”

Ingram’s editorial is followed by four articles in a special section of the journal’s Biological Sciences section. One of the studies found that consuming 200 grams of blueberries (about one cup) daily can improve blood vessel function and decrease systolic blood pressure. As the cause, the authors cited anthocyanins, which are phytochemicals that give blueberries their dark color.

Other studies document the cognitive benefits of eating blueberries. One tied the fruit’s high polyphenol count to improved performance on memory tests by a group of older adults. Likewise, another journal article provides a review of several clinical studies focusing on benefits of blueberry supplementation — with a focus on specific memory effects in children as well as older adults with mild cognitive impairment.

The journal collection also includes a rodent study, which presents data on the improved memory performance of blueberry-supplemented aged rats compared to rats on a control diet.

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Seniors Improve Brain Function by Raising Fitness Level – University of Kansas

Science Daily reported that a professor of neurology at KU Alzheimer’s Disease Center, led a six-month trial conducted with healthy adults ages 65 and older who showed no signs of cognitive decline.

The randomized controlled trial attempted to determine the ideal amount of exercise necessary to achieve benefits to the brain.

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Before proceeding, I would like to add that I am now in my tenth year of writing this blog. To continue that long at a healthy pace (+3000 posts) you have to be motivated and get positive feedback.

Reading about this new study on exercise benefiting the brain was extraordinarily positive feedback. I have written about the benefits of exercise and the brain for several years. You can check out my Page – Important Facts About Your Brain (and Exercise) for more details. Suffice it to say that the KU report was most welcome. Continue reading

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Left brain vs right brain …

The human brain fascinates me for lots of reasons. I have taken several courses in it from The Great Courses and recommend them for anyone curious about this amazing organ that lives inside our heads. I have written a number of posts on various aspects of the brain which I recommend your chasing down. Just type in b r a i n into the SEARCH BOX at the right. Also, you can check out my Page – Important facts about your brain (and exercise benefits). Last, but not least, of course, there is the specter of dementia in general and Alzheimer’s Disease, in particular. I have lost three family members to these afflictions and, at the age of 79, I am very focused on my mental functions. Which brings us to this wonderful article in Medical News Today on the two hemispheres of the brain – the left and the right.

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The two hemispheres or sides of the brain have slightly different jobs. But can one side be dominant and does this affect personality?

Some people believe that a person is either left-brained or right-brained and that this determines the way they think and behave.

In this article, we explore the truth and fallacy behind this claim. Read on to learn more about the functions and characteristics of the left and right brain. Continue reading

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Looking forward to a better second half …

Here in the first week of July we have just entered the second half of 2019. So far 2019 has been a rough go for me. Back in March I wrote about the physical therapy for my back pains as well as the problems I was having with my teeth. You can find the gory details at Spoiler alert – on being 79 years old.

Then in mid-April, I followed up with the details of my subsequent oral surgery and, of course, forced down time to recover. You can read the details here: Taking physical downtime.

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My dog has been patient with me. When I started riding in the warmer weather, I did not have the energy to bring her along. Clearly, she likes to accompany me.

Later in April, I wrote an update on my recovery from surgery and biking. As I said in the post, at the age of 79, most of my biking friends are decades younger, so I have a hard time understanding how well (or not) my body is recovering. I quoted the MacArthur Foundation book Successful Aging for a partial reference on that.

I did find some interesting info on aging and fighting illness in the MacArthur book. they compare a 30-year-old with his 80-year-old grandfather afflicted with pneumonia. Here is the part that interested me most, the course of the senior’s illness “might be very grave indeed. This is because the average 80-year-old non-smoker has only about two-thirds the lung function of his 30-year-old counterpart. And, his immune system is impaired as well. ” So, what I drew from this is that my recovery from the surgery will be slow, but is probably on track.

In the first week of June I wrote about my latest and greatest affliction – a bronchial virus. You can read the details at – 7 Days makes one weak.

I came down with the fever on May 26 and was unable to ride my bike for the next three weeks. I have to tell you that I can not remember the last three week period in my life that I did not ride my bike. Even when I was married and working, I always got my rides in.

Here, in the first week of July I can state that I am recovering – not fully recovered from the virus of late May. After my three week down time, I began riding in tiny bits, five miles a day, then eight miles. At this point I am able to get in my usual 30 mile rides, but I find myself napping for at least an hour or more later in the day. Managing my recovery is like walking a tightrope. I work on getting exercise, but have to be careful that I do not go too far, and set myself back. To compound the difficulty, July heat has come to Chicago so I have that to contend with, too. It is clearly a – one day at a time deal.

As I wrote in the header to this post, I am looking forward to a better second half. So as to not leave you on a sour note. I am off to Las Vegas with my girl friend in a couple of weeks. Looking forward to that.

Tony

 

 

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Some dementia patients show moments of clarity at end of life – Study

It happens unexpectedly: a person long thought lost to the ravages of dementia, unable to recall the events of their lives or even recognize those closest to them, will suddenly wake up and exhibit surprisingly normal behavior, only to pass away shortly thereafter. This phenomenon, which experts refer to as terminal or paradoxical lucidity, has been reported since antiquity, yet there have been very few scientific studies of it. That may be about to change.

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In an article published in the August issue of Alzheimer’s & Dementia , an interdisciplinary workgroup convened by the National Institutes of Health’s (NIH) National Institute on Aging and led by Michigan Medicine’s George A. Mashour, M.D., Ph.D., outlines what is known and unknown about paradoxical lucidity, considers its potential mechanisms, and details how a thorough scientific analysis could help shed light on the pathophysiology of dementia. Continue reading

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