Category Archives: dementia

Healthy eating may reduce risk of dementia – AAIC Conference

Because of the Alzheimer’s Disease and dementia in my family, I have been an avid student of ways to protect myself as I age. Check out my Page – Important facts about your brain (and exercise benefits) for more. Regarding our general physical health I know that diet contributes about 70 percent and exercise 30 percent. It turns out that diet also provides important elements of brain health, too.

Results from four large population-based studies support a connection between good dietary practices and better cognition in old age. Study results were reported at the 2017 Alzheimer’s Association International Conference (AAIC 2017) in London.

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A group of U.S. scientists found that, among nearly 6,000 older adults in the Health and Retirement Study, those who consistently followed diets long known to contribute to cardiovascular health were also more likely to maintain strong cognitive function in old age. They found that sticking to the specially designed MIND diet and Mediterranean diet was associated with 30 to 35 percent lower risk of cognitive impairment in healthy older adults. In fact, the investigators discovered that those with healthier diets exhibited meaningful preservation of cognitive function.

  • The Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets were originally developed or codified to help improve cardiovascular health.
  • A hybrid of these diets, called the Mediterranean-DASH Intervention for Neurodegenerative Delay, or MIND diet, is gaining attention for its potential positive effects on preserving cognitive function and reducing dementia risk in older individuals. A 2015 study found that individuals adhering to this diet exhibited less cognitive decline as they aged (Morris et al. Alzheimer’s Dement. 2015; 11:1015-22).

Other diet-related studies reported at AAIC 2017 included:

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Cholesterol may affect brain functions – Study

Having lost three family members to Alzheimer’s Disease and dementia, I was fascinated by this information from researchers in Berlin.

A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM) and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer’s.

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The adenosine receptor belongs to the GPCR family (G Protein-Coupled Receptors), a large group of proteins located in cell membranes, which are key in the transmission of signals and communication between cells. GPCRs are therefore involved in the majority of important physiological processes, including the interpretation of sensory stimuli such as vision, smell, and taste, the regulation of the immune and inflammatory system, and behavior modulation. Continue reading

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Tea drinking may help prevent dementia – Harvard

Good news for tea drinkers or all stripes. A study in the December 2016 Journal of Nutrition, Health & Aging showed that drinking tea frequently is associated with a lower risk of dementia, especially for people who are genetically predisposed to the disease, Harvard Men’s Health Watch reported.

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Researchers followed 957 older adults, average age 65, who were part of the Singapore Longitudinal Aging Study. Of these, 69% drank tea on a frequent basis. After a five-year period, the researchers found that the tea drinkers had a 50% lower risk of dementia. This is consistent with earlier findings that showed tea consumers scored higher on various cognitive tests.

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Genes Associated With Resilience Against Brain Pathology Identified

Having had three family members who suffered from some form of dementia I am highly motivated to find out all I can about this scourge that devastates mostly seniors. The following is from the Rush Alzheimer’s Disease Center.
Genes help cognition withstand damage in brain from Alzheimer’s, Parkinson’s

The pathologies (damage) in the brain that stroke, Alzheimer’s disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it.

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Now researchers have discovered two genes, known as UNC5C and ENC1, that are associated with aging individuals having better memory and brain function than would be expected, given the amount of pathologies that accumulated in their brains. They reported their findings in an article published today in the journal PLOS Medicine. Continue reading

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Rapid middle age blood pressure drops linked to dementia in old age – Study

Regular readers know how much I follow developments in the study of the brain. Here is some fresh fascinating info from Johns Hopkins.

Summary: Researchers report orthostatic hypotension could cause lasting damage to the brain because it can reduce blood flow to the brain.

Middle-aged people who experience temporary blood pressure drops that often cause dizziness upon standing up may be at an increased risk of developing cognitive decline and dementia 20 years later, new Johns Hopkins Bloomberg School of Public Health research suggests.

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The findings, being presented March 10 at the American Heart Association’s EPI|LIFESTYLE 2017 Scientific Sessions in Portland, Ore., suggest that these temporary episodes – known as orthostatic hypotension – may cause lasting damage, possibly because they reduce needed blood flow to the brain. Previous research has suggested a connection between orthostatic hypotension and cognitive decline in older people, but this appears to be the first to look at long-term associations. (my emphasis)

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Women perform better than men on memory tests for Alzheimer’s

Since I have at least three cases of Alzheimer’s or dementia in my family, this kind of information always resonates with me.

Women do better on verbal memory tests commonly used to diagnose Alzheimer’s disease compared to men with the same amount of neurotoxic protein in their brains, a new study has found.

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It is well known that females have an advantage on verbal memory tests, in which subjects are challenged to recite back a list of heard words. Because women are better at the tests, which are often used to help detect and diagnose Alzheimer’s disease, the severity of their disease may be missed, says Dr. Pauline Maki, professor of psychiatry and psychology at the University of Illinois at Chicago and an author on the study, published in the Journal of Alzheimer’s Disease.

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Delirium could accelerate dementia-related mental decline

It ain’t easy being green, according to Kermit. Turns out it ain’t so easy being old either.

New research by UCL and University of Cambridge shows delirium may have long-lasting consequences, including accelerating the dementia process

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When hospitalized, people can become acutely confused and disorientated. This condition, known as delirium, affects a quarter of older patients and new research by UCL and University of Cambridge shows it may have long-lasting consequences, including accelerating the dementia process.

The study, published today in the journal JAMA Psychiatry, is the first to show the multiplying effects of delirium and dementia in these patients.

Episodes of delirium in people who are not known to have dementia, might also reveal dementia at its earliest stages, the research found.

While both delirium and dementia are important factors in cognitive decline among the elderly, delirium is preventable and treatable through dedicated geriatric care.

Further research is needed to understand exactly how delirium interacts with dementia, and how this could be blocked.

“If delirium is causing brain injury in the short and long-term, then we must increase our efforts to diagnose, prevent and treat delirium. Ultimately, targeting delirium could be a chance to delay or reduce dementia” said Dr. Daniel Davis (MRC Unit for Lifelong Health and Ageing at UCL), who led the research while at the University of Cambridge.

Scientists looked at three European populations – in Finland, Cambridge and UK-wide – and examined brain specimens in 987 people aged 65 and older. Each person’s memory, thinking and experience of delirium had been recorded over 10 years towards the end of their life.

When these were linked with pathology abnormalities due to Alzheimer’s and other dementias, those with both delirium and dementia-changes had the most severe change in memory.

Dr Davis added: “Unfortunately, most delirium goes unrecognized. In busy hospitals, a sudden change in confusion not be noticed by hospital staff. Patients can be transferred several times and staff often switch over – it requires everyone to ‘think delirium’ and identify that a patient’s brain function has changed.”

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High cholesterol intake and eggs do not increase risk of memory disorders

I am now and  have been for years a big fan of eggs. A hundred years ago, it seems, I worked on the Chicago Mercantile Exchange trading floor where I covered the egg futures market along with pork bellies, live cattle and live hog futures. In that capacity, I learned a great deal about eggs from their production to our consumption. I have posted on them numerous times. Here are a few: Eating eggs is good for you. I wrote that in the first month of this blog’s existence. Feel free to type e-g-g-s in the search box at the right to read more posts on eggs.

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A new study from the University of Eastern Finland shows that a relatively high intake of dietary cholesterol, or eating one egg every day, is not associated with an elevated risk of dementia or Alzheimer’s disease. Furthermore, no association was found in persons carrying the APOE4 gene variant that affects cholesterol metabolism and increases the risk of memory disorders. APOE4 is common in Finland. The findings were published in the American Journal of Clinical Nutrition. Continue reading

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Frequent sauna bathing protects men against dementia

I don’t handle discomfort well, so sitting in a sauna sweating has never appealed to me. Having said that, as regular readers know I have lost three family members to Alzheimer’s or general dementia, so my radar shoots up to high when it comes to impaired cognition.

Frequent sauna bathing can reduce the risk of dementia, according to a recent study carried out at the University of Eastern Finland. In a 20-year follow-up, men taking a sauna 4-7 times a week were 66% less likely to be diagnosed with dementia than those taking a sauna once a week. The association between sauna bathing and dementia risk has not been previously investigated.

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The effects of sauna bathing on the risk of Alzheimer’s disease and other forms of dementia were studied in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), involving more than 2,000 middle-aged men living in the eastern part of Finland. Based on their sauna-bathing habits, the study participants were divided into three groups: those taking a sauna once a week, those taking a sauna 2-3 times a week, and those taking a sauna 4-7 times a week.

The more frequently saunas were taken, the lower was the risk of dementia. Among those taking a sauna 4-7 times a week, the risk of any form of dementia was 66% lower and the risk of Alzheimer’s disease 65% lower than among those taking a sauna just once a week. The findings were published recently in the Age and Ageing journal.

Previous results from the KIHD study have shown that frequent sauna bathing also significantly reduces the risk of sudden cardiac death, the risk of death due to coronary artery disease and other cardiac events, as well as overall mortality. According to Professor Jari Laukkanen, the study leader, sauna bathing may protect both the heart and memory to some extent via similar, still poorly known mechanisms. “However, it is known that cardiovascular health affects the brain as well. The sense of well-being and relaxation experienced during sauna bathing may also play a role.”

Tony

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The three stages of Alzheimer’s Disease – NIA

November is Alzheimer’s Awareness Month. As a person with family members on both sides who have suffered from dementia in general and Alzheimer’s in particular, I wanted to share this with you, from the Alzheimer’s Disease Education & Referral center.

The first symptoms of Alzheimer’s vary from person to person. For many, difficulty with tasks like word-finding, vision/spatial issues, and impaired reasoning or judgment, may signal the very early stages of Alzheimer’s disease.

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Typically, Alzheimer’s progresses in three stages: Continue reading

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What are some actions that prevent or delay Dementia and Alzheimer’s?

The question of brain games and other cerebral activities to prevent or delay dementia and Alzheimer’s Disease was taken up by The Ask the Expert column in the Alzheimer’s Prevention Registry.

“What kinds of brain activities did we find to be beneficial? While more research is needed to learn the best types of activities, the studies we reviewed included a wide range of possibilities….”

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“Here are some ideas:
•    Read a novel, a non-fiction book, a magazine, or newspaper.
•    Play board games with your children or grandkids.
•    Volunteer for a local organization.
•    Host a weekly card game for friends.
•    Register for an adult education class at your local college.
•    Look for art, cooking or other fun classes in your community.
•    Play video games with a young person in your life.
•    Attend a play or visit a museum.

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Can Ayurveda Help with Dementia and Alzheimer’s?

Because my family has suffered from both Alzheimer’s and dementia, I am especially sensitive to anything that might reduce my vulnerability to them. I really  liked the Tips to Nourish Your Brain at the end.

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Please be sure to check out my Page – Important facts about your brain (and exercise benefits) for more information.

Tony

STAYING HEALTHY WITH AYURVEDA

Alzheimer’s Disease is the most common cause of dementia, a brain disorder affecting the parts of the brain controlling thought, memory and language. About 4.5 million Americans suffer from Alzheimer’s and the number of cases are expected to quadruple by 2050. Ayurveda, the original health science of India, offers much needed knowledge on how to reverse aging trends, even in cases of brain deterioration such as Alzheimer’s disease.

Early detection provides a greater opportunity to delay or reverse the existing symptoms of aging disorders. Ayurveda, offers a comprehensive system of effective interventions.

A consultation with an Ayurvedic health expert using the ancient technique of Ayurvedic pulse assessment can help with early detection. Pulse assessment can help identify specific imbalances in the body which can predispose an individual to the onset of Alzheimer’s disease and other neurological disorders. This individual diagnosis is a powerful tool for designing an individualized treatment program and…

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New study suggests rethink of dementia causes

Since I have both Alzheimer’s and dementia on both sides of my family tree, I am always interested in studies on the subject.

University of Adelaide researchers have developed a new theory for the causes of dementia and other neurodegenerative diseases, involving an out-of-control immune system.

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Published in the journal Frontiers in Neuroscience, the researchers have assembled strong evidence that the neurological decline common to these diseases is caused by ‘auto-inflammation’, where the body’s own immune system develops a persistent inflammatory response and causes brain cells to die.

“Dementia, including the most common form, Alzheimer’s Disease, and related neuro-degenerative conditions are dramatically rising in frequency as people live longer and our population ages,” says study lead Professor Robert Richards, from the University of Adelaide’s School of Biological Sciences. “Australia is predicting that by 2050 there will be almost double the number of people with dementia, and the United States similarly says there will be twice as many.

“Currently, we have no effective treatments to assist the millions of affected people, and these diseases are an enormous burden on families and the public health care system.”

Previously, researchers have focused on the role of protein deposits called amyloid plaques that lodge in the brain of Alzheimer’s affected people. But it is now clear that this is an inadequate explanation for Alzheimer’s Disease.

There are many distinct forms of neuro-degeneration including Alzheimer’s, Parkinson’s and Huntington’s Diseases. These conditions are distinguished by the different types of brain nerve cells that are first affected and by the symptoms that first appear. However, as all of these diseases progress, they become more similar.

Professor Richards believes that instead of many different mechanisms, each disease has the same underlying mechanism, and common pathway of nerve cell loss.

“Our interest in the body’s own (innate) immune system as the culprit began when we discovered that immune system agents become activated in a laboratory model of Huntington’s Disease,” he says. “Remarkably, researchers from other laboratories were at the same time reporting similar features in other neuro-degenerative diseases. When we pulled the evidence together, it made a very strong case that uncontrolled innate immunity is indeed the common cause.”

The innate immune system is the first line of defense in cells, and normally distinguishes molecules that belong to the body from foreign, disease-causing, molecules. It is an alarm and response system with a self-destruct mechanism to contain and eliminate invaders or abnormal cells, like cancer.

Malfunctions can occur because of various triggers including genetic mutations, infection, toxins or physical injury, all of which have been linked with different forms of neuro-degeneration. Initially the innate immune system protects the tissue against these triggers, but prolonged activation becomes self-perpetuating, causing brain cell death to occur.

“We hope this new way of understanding neuro-degeneration will lead to new treatments,” Professor Richards says. “We now need to further investigate the immune signaling molecules, to identify new drug targets that will delay the onset and/or halt the progression of these devastating diseases.”

While the jury is still out on these findings, I would recommend continuing along previously successful lines. Check out my Page – Important facts about your brain (and exercise benefits) to learn more.

Tony

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The Amount of Coffee That Protects Against Dementia Precursor

Having posted on Alzheimer’s a few hours ago, I thought you should see this interesting post on coffee.

While we are on the subject, please be sure to check my Page – Important Facts About Your Brain (and Exercise Benefits)

Tony

Our Better Health

How coffee intake affects the chance of developing mild cognitive impairment.

Drinking one or two cups of coffee a day can protect the brain against a precursor to dementia, a new study finds.

More coffee, though, does not lead to a higher neuro-protective effect.

In fact, the study found that people who increased their consumption by a cup or two had twice the risk of mild cognitive impairment (MCI).

MCI is a common precursor to developing forms of dementia, like Alzheimer’s disease.

Symptoms of MCI include minor memory problems and slowed thinking and judgement.

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The Italian study of 1,445 people also found that people not drinking coffee were at higher risk than those who drank moderate amounts.

The study’s authors write:

“These findings from the Italian Longitudinal Study on Aging suggested that cognitively normal older individuals who never or rarely consumed coffee and those who increased their coffee consumption habits…

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7 Ways to Cut Your Alzheimer’s Disease Risk – Infographic

Regular readers know that I have a special sensitivity to Alzheimer’s and dementia as I have lost several family members who were afflicted. There are no guarantees about preventing Alzheimer’s, but this infographic presents some good techiques for reducing your risk. In addition, please check out my Page – Important Facts About Your Brain (and Exercise) for details on how much the brain benefits from exercise.

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Regarding the first point about saturated fats, organic coconut oil is an exception. Please check out my Page – Coconut Oil – Why You Should Include it in Your Diet. I start every day with a tablespoon of peanut butter dipped in coconut oil.

Tony

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Simple Blood Test Can Predict Risk of Dementia

Globally, in excess of 35 million people suffer dementia – in Denmark alone, there are approx. 80,000 who suffer this illness. Prevalence increases in step with aging, and as people’s life years are continually on the rise in most countries, there is also an increasing need to be able to identify the citizens who are at the greatest risk of suffering dementia.

Regular readers know that dementia and Alzheimer’s are both extremely important to me as my mother and her sister suffered from them. That is the primary reason I have written so much about the brain here. I consider myself to be genetically predisposed to some kind of mental failing. Over the past five years of blogging I have written numerousposts on the subject. To read further, please check my Page – Important Facts About Your Brain (and Exercise). The latest findings in neuroscience indicate that cardiovascular exercise sends oxygen molecules to the brain where new brain cells are created. Therein lies my hope (and yours) of escaping Cognitive Impairment.

Tony

Cooking with Kathy Man

Scientists at Rigshopitalet, Herlev Hospital and the University of Copenhagen identify a new biomarker that can predict the risk of developing dementia by way of a simple blood test. In the long term, this could mean better prevention and thus at least postponement of the illness and at best evading the development all together. The study was recently published in an internationally acclaimed journal, the Annals of Neurology.

Globally, in excess of 35 million people suffer dementia – in Denmark alone, there are approx. 80,000 who suffer this illness. Prevalence increases in step with aging, and as people’s life years are continually on the rise in most countries, there is also an increasing need to be able to identify the citizens who are at the greatest risk of suffering dementia.

As opposed to cardiovascular diseases, where the level of cholesterol in our blood indicates the risk of cardiac arrest, there…

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