Tag Archives: stress

BrainHealth research demonstrates positive impact of online SMART training

The Strategic Memory Advanced Reasoning Tactics (SMART™) brain health training protocol has been shown to improve symptoms of depression, anxiety and stress when delivered in person. New research from Center for BrainHealth® at The University of Texas at Dallas demonstrates the effectiveness of online delivery of SMART.

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SMART training features strategies to strengthen the brain’s frontal networks and achieve significant, measurable brain changes and improvements. This brain health training program promotes improvements in both trained and untrained areas of cognitive functioning, including strategic attention, innovation, working memory and real-life executive function behaviors. In addition to improving cognitive function, SMART has also demonstrated unexpected benefits in mental health markers.

The research, “Effects of Online Brain Training on Self-Reported Mental Health Symptoms for Generally Healthy Adults During the COVID-19 Pandemic,” was published in Brain and Behavior.

This study investigated the effects of a 12-week, self-paced, online SMART training on mental health on 145 participants between the ages of 18-78 years. Participants included 106 females and 39 males. Participants self-reported mental health symptoms on the Depression Anxiety Stress Scale (DASS-21), a tool to measure the negative emotional states of depression, anxiety and tension/stress, both pre- and post- training. Although the participants consisted of healthy adults, some reported symptoms of psychological distress at baseline pre-training on the DASS-21, particularly in the younger age groups.

Improvements in depression, anxiety and stress symptoms were observed following online SMART, evidenced by a significant decrease in self-reported symptoms on the DASS-21. While SMART training generally yielded mental health benefits across age, gender and education levels, additional exploration is warranted to explore how age and education may affect expression of symptom subtypes.

The lasting impact of this training was revealed in data from 44 participants who completed a follow-up DASS-21 six months after the initial training and showed that improvement in self-reported mental health symptoms was maintained or continued to expand post-training. These findings suggest that SMART may be an effective tool to help those experiencing pre-clinical mental health symptoms, particularly for depression and stress.

Lead author Sarah Laane, MS, CCC-SLP, a research clinician and doctoral student at Center for BrainHealth, stated these findings indicate that participants who completed online SMART experienced similar mental health benefits to those previously demonstrated after in-person SMART programs and demonstrates support for the use of online SMART as a potential low-cost, high-impact tool to support mental health.

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Frequent visits to green space linked to lower use of certain prescription meds

Frequent visits to urban green spaces, such as parks and community gardens in Finland, rather than the amount, or views of them from home, may be linked to lower use of certain prescription meds, suggests research published online in Occupational & Environmental Medicine.

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The observed associations between frequent green space visits and lower use of drugs for depression, anxiety, insomnia, high blood pressure, and asthma were not dependent on socio-economic position.

Exposure to natural environments is thought to be good for health, but the evidence is inconsistent, say the researchers.

They wanted to find out if the amount of residential green and blue space (bodies of water), frequency of green space visits, and views of green and blue spaces from home might be separately associated with the use of certain prescription meds.

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Female and male hearts respond differently to stress hormone in mouse study

A new study published in Science Advances shows female and male hearts respond differently to the stress hormone noradrenaline. The study in mice may have implications for human heart disorders like arrhythmias and heart failure and how different sexes respond to medications.

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The team built a new type of fluorescence imaging system that allows them to use light to see how a mouse heart responds to hormones and neurotransmitters in real time. The mice were exposed to noradrenaline, also known as norepinephrine. Noradrenaline is both a neurotransmitter and hormone associated with the body’s “fight or flight” response.

The results reveal that male and female mouse hearts respond uniformly at first after exposure to noradrenaline. However, some areas of the female heart return to normal more quickly than the male heart, which produces differences in the heart’s electrical activity.

“The differences in electrical activity that we observed are called repolarization in the female hearts. Repolarization refers to how the heart resets between each heartbeat and is closely linked to some types of arrhythmias,” said Jessica L. Caldwell, first author of the study. Caldwell is a postdoctoral scholar in the UC Davis School of Medicine Department of Pharmacology.

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Stress has an odor and dogs can smell it …

Dogs can smell stress from human sweat and breath, a new study by Queen’s University Belfast researchers has found.

The study involved four dogs from Belfast – Treo, Fingal, Soot and Winnie – and 36 people.

This is my new dog, Boots, helping to keep my stress levels down.

Researchers collected samples of sweat and breath from participants before and after they did a difficult maths problem. They self-reported their stress levels before and after the task and researchers only used samples where the person’s blood pressure and heart rate had increased.

The dogs were taught how to search a scent line-up and alert researchers to the correct sample. The stress and relaxed samples were then introduced but at this stage the researchers didn’t know if there was an odour difference that dogs could detect.

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Social stress contributes to accelerated aging of the immune system – NIH

Exposure to social stress was associated with accelerated aging of the immune system, according to an NIA-funded study recently published in PNAS. The body’s immune system changes as people age, and there’s large variability in these changes. The study, led by researchers at UCLA, investigated whether social stressors added to immune system decline.

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The researchers analyzed data from more than 5,500 people enrolled in the Health and Retirement Study, a long-term, nationally representative study of Americans over age 50. The researchers measured stress by analyzing responses to questions about exposure to various types of social stress, including discrimination, trauma, and other life events, such as unemployment. They also analyzed the participants’ immune profiles — a snapshot of immune system function — by drawing blood and measuring white blood cell levels, specifically T lymphocytes (also called T cells). T cells are an essential part of the immune system and help the body fight off infection.

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Resilience to stress can be measured and controlled in the brain and body

Recent research has begun to identify the neural mechanisms in stress responses that may lead to the development of resilience. The findings were presented at Neuroscience 2021, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health.

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Resilience to stress is the ability of an individual to cope with hardship; this ability comes easier to some individuals than others.  A person’s level of resilience can be a determining factor for successfully coping with stressful events. Individuals who suffer from post-traumatic stress disorder (PTSD), anxiety, depression, and other disorders may one day benefit from treatments targeting specific circuits and regions of the brain. However, the exact mechanisms of resilience, such as how it mediates the relationship between the brain and the rest of the body, are not yet known. 

New findings show:

  • Activation of a subset of touch neurons in the skin can reduce stress hormones after minor stress; the elimination of these neurons leads to depression-like behavior (Melanie Schaffler, University of Pennsylvania).
  • In rats who exhibit high anxiety and passive coping behavior, biological sex moderates the presence of resilience and active coping styles in adulthood after adolescent stress (Eva E. Redei, Feinberg School of Medicine, Northwestern University).
  • PTSD-prone rats have higher levels of urinary adrenaline and more inflammation-associated bacteria in their gut; exposure to stress significantly alters their gut microbiota (Esther Sabban, New York Medical College).

“Stress affects us in many ways, and these studies show us that resilience is also multi-faceted,” said press conference moderator Martha Farah, Walter H. Annenberg Professor in Natural Sciences and director of the Center for Neuroscience & Society at the University of Pennsylvania. “Discovering the brain mechanisms of resilience is arguably the holy grail of psychiatry. These findings will contribute to new treatments for PTSD and other anxiety and mood disorders.”

Everyone experiences stress in their lives. To read further on it in this blog, type STRESS into the Search Box on the right.

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Resilience to stress can be measured and controlled in the brain and body

Recent research has begun to identify the neural mechanisms in stress responses that may lead to the development of resilience. The findings were presented at Neuroscience 2021, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health.

Photo by Nathan Cowley on Pexels.com

Resilience to stress is the ability of an individual to cope with hardship; this ability comes easier to some individuals than others.  A person’s level of resilience can be a determining factor for successfully coping with stressful events. Individuals who suffer from post-traumatic stress disorder (PTSD), anxiety, depression, and other disorders may one day benefit from treatments targeting specific circuits and regions of the brain. However, the exact mechanisms of resilience, such as how it mediates the relationship between the brain and the rest of the body, are not yet known. 

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Broken heart syndrome rising among older women – AHA

Broken heart syndrome, a life-threatening condition whose symptoms mimic a heart attack, is on the upswing, according to new research that shows the sharpest increases among women 50 and older.

Published in the Journal of the American Heart Association, the study examined 135,463 cases of broken heart syndrome in U.S. hospitals from 2006 to 2017. It found a steady annual increase among both women and men, with women making up 88.3% of the cases.

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The overall increase wasn’t unexpected as the condition has become increasingly recognized among medical professionals, said Dr. Susan Cheng, the study’s senior author. But researchers were taken aback to find the rate of the condition was at least six to 12 times higher in women ages 50 to 74 than it was in men or in younger women.

“These skyrocketing rates are both intriguing and concerning,” said Cheng, director of the Institute for Research on Healthy Aging in the department of cardiology at the Smidt Heart Institute at Cedars-Sinai in Los Angeles.

The condition, also known as Takotsubo cardiomyopathy, has been studied for decades in Japan and elsewhere. But it wasn’t well known internationally until 2005, when the New England Journal of Medicine published research on it.

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It’s true: Stress does turn hair gray (and it’s reversible)

Legend has it that Marie Antoinette’s hair turned gray overnight just before her beheading in 1791.

Though the legend is inaccurate–hair that has already grown out of the follicle does not change color–a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons is the first to offer quantitative evidence linking psychological stress to graying hair in people.

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And while it may seem intuitive that stress can accelerate graying, the researchers were surprised to discover that hair color can be restored when stress is eliminated, a finding that contrasts with a recent study in mice that suggested that stressed-induced gray hairs are permanent.

The study, published June 22 in eLife, has broader significance than confirming age-old speculation about the effects of stress on hair color, says the study’s senior author Martin Picard, PhD(link is external and opens in a new window), associate professor of behavioral medicine (in psychiatry and neurology) at Columbia University Vagelos College of Physicians and Surgeons.

“Understanding the mechanisms that allow ‘old’ gray hairs to return to their ‘young’ pigmented states could yield new clues about the malleability of human aging in general and how it is influenced by stress,” Picard says.

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New study uncovers details behind the body’s response to stress

Study Highlights

  • New research reveals how key proteins interact to regulate the body’s response to stress
  • Targeting these proteins may help treat or prevent stress-related psychiatric disorders

The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood.

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New research now details the interplay between proteins involved in controlling the body’s stress response and points to potential therapeutic targets when this response goes awry. The study, which was conducted by an international team led by investigators at McLean Hospital, appears in the journal Cell Reports.

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Alcohol in moderation may help the heart by calming stress signals in the brain – Study

Moderate alcohol intake — defined as no more than one alcoholic drink for women and two for men per day — has been associated with a lower risk of dying from cardiovascular disease when compared with individuals who abstain from drinking or partake in excessive drinking, according to a new study being presented at the American College of Cardiology’s 70th Annual Scientific Session. It’s also the first study to show that drinking moderate amounts of alcohol may be heart protective, in part, by reducing stress-related brain signals based on a subset of patients who underwent brain imaging.

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“We found that stress-related activity in the brain was higher in non-drinkers when compared with people who drank moderately, while people who drank excessively (more than 14 drinks per week) had the highest level of stress-related brain activity,” said Kenechukwu Mezue, MD, a fellow in nuclear cardiology at Massachusetts General Hospital and the study’s lead author. “The thought is that moderate amounts of alcohol may have effects on the brain that can help you relax, reduce stress levels and, perhaps through these mechanisms, lower the incidence of cardiovascular disease.”

While Mezue was quick to caution that these findings should not encourage alcohol use, he said they could open doors to new therapeutics or prescribing stress-relieving activities like exercise or yoga to help minimize stress signals in the brain.

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COVID-19 may have increased mental health issues within families – Study

When the COVID-19 pandemic hit in early 2020, many families found themselves suddenly isolated together at home. A year later, new research has linked this period with a variety of large, detrimental effects on individuals’ and families’ well-being and functioning.

The study — led by Penn State researchers — found that in the first months of the pandemic, parents reported that their children were experiencing much higher levels of “internalizing” problems like depression and anxiety, and “externalizing” problems such as disruptive and aggressive behavior, than before the pandemic. Parents also reported that they themselves were experiencing much higher levels of depression and lower levels of coparenting quality with their partners.

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Mark Feinberg, research professor of health and human development at Penn State, said the results — recently published in the journal Family Process — give insight into just how devastating periods of family and social stress can be for parents and children, and how important a good coparenting relationship can be for family well-being.

“Stress in general — whether daily hassles or acute, crisis-driven stress — typically leads to greater conflict and hostility in family relationships,” Feinberg said. “If parents can support each other in these situations, the evidence from past research indicates that they will be able to be more patient and more supportive with their children, rather than becoming more harsh and angry.”

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Stress from work and social interactions put women at higher coronary heart disease risk

Psychosocial stress – typically resulting from difficulty coping with challenging environments – may work synergistically to put women at significantly higher risk of developing coronary heart disease, according to a study by researchers at Drexel University’s Dornsife School of Public Health, recently published in the Journal of the American Heart Association.

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The study specifically suggests that the effects of job strain and social strain — the negative aspect of social relationships — on women is a powerful one-two punch. Together they are associated with a 21% higher risk of developing coronary heart disease. Job strain occurs when a woman has inadequate power in the workplace to respond to the job’s demands and expectations.

The study also found that high-stress life events, such as a spouse’s death, divorce/separation or physical or verbal abuse, as well as social strain, were each independently linked with a 12% and 9% higher risk of coronary heart disease, respectively.

The Drexel study used data from a nationally representative sample of 80,825 postmenopausal women from the Women’s Health Initiative Observational Study, which tracked participants from 1991 to 2015, to find better methods of preventing cancer, heart disease and osteoporosis in women. In the current follow-up study, Drexel researchers evaluated the effect of psychosocial stress from job strain, stressful life events and social strain (through a survey), and associations among these forms of stress, on coronary heart disease.

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Can drinking cocoa protect your heart when you’re stressed?

Increased consumption of flavanols – a group of molecules occurring naturally in fruit and vegetables – could protect people from mental stress-induced cardiovascular events such as stroke, heart disease and thrombosis, according to new research.

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Researchers have discovered that blood vessels were able to function better during mental stress when people were given a cocoa drink containing high levels of flavanols than when drinking a non-flavanol enriched drink.

A thin membrane of cells lining the heart and blood vessels, when functioning efficiently the endothelium helps to reduce the risk of peripheral vascular disease, stroke, heart disease, diabetes, kidney failure, tumor growth, thrombosis, and severe viral infectious diseases. We know that mental stress can have a negative effect on blood vessel function.

A UK research team from the University of Birmingham examined the effects of cocoa flavanols on stress-induced changes on vascular function – publishing their findings in Nutrients.

Lead author, Dr. Catarina Rendeiro, of the University of Birmingham’s School of Sport, Exercise and Rehabilitation Sciences, explains: “We found that drinking flavanol-rich cocoa can be an effective dietary strategy to reduce temporary impairments in endothelial function following mental stress and also improve blood flow during stressful episodes”.

“Flavanols are extremely common in a wide range of fruit and vegetables. By utilizing the known cardiovascular benefits of these compounds during periods of acute vascular vulnerability (such as stress) we can offer improved guidance to people about how to make the most of their dietary choices during stressful periods.”

In a randomized study, conducted by postgraduate student Rosalind Baynham, a group of healthy men drank a high-flavanol cocoa beverage 90 minutes before completing an eight-minute mental stress task.

The researchers measured forearm blood flow and cardiovascular activity at rest and during stress and assessed functioning of the blood vessels up to 90 min post stress – discovering that blood vessel function was less impaired when the participants drank high-flavanol cocoa. The researchers also discovered that flavanols improve blood flow during stress.

Stress is highly prevalent in today’s society and has been linked with both psychological and physical health. Mental stress induces immediate increases in heart rate and blood pressure (BP) in healthy adults and also results in temporary impairments in the function of arteries even after the episode of stress has ceased.

Single episodes of stress have been shown to increase the risk of acute cardiovascular events and the impact of stress on the blood vessels has been suggested to contribute to these stress-induced cardiovascular events. Indeed, previous research by Dr Jet Veldhuijzen van Zanten, co-investigator on this study, has shown that people at risk for cardiovascular disease show poorer vascular responses to acute stress.

“Our findings are significant for everyday diet, given that the daily dosage administered could be achieved by consuming a variety of foods rich in flavanols – particularly apples, black grapes, blackberries, cherries, raspberries, pears, pulses, green tea and unprocessed cocoa. This has important implications for measures to protect the blood vessels of those individuals who are more vulnerable to the effects of mental stress,” commented Dr. Rendeiro.

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Pandemic has severely disrupted sleep, increasing stress and medication use – Study

The COVID-19 pandemic is seriously affecting the sleep habits of half of those surveyed in a new study from The Royal and the University of Ottawa, leading to further stress and anxiety plus further dependence on sleep medication.

The global pandemic’s impact on daily routines extends to the bed, according to ‘Profiles of sleep changes during the COVID?19 pandemic: Demographic, behavioural and psychological factors’. The study was led by Principal Investigator Rébecca Robillard, an Assistant Professor and co-director of the Sleep Laboratory of the School of Psychology at the University of Ottawa, and Head Scientist in the Sleep Research Unit at The Royal Institute of Mental Health Research and published in the Journal of Sleep Research.

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Dr. Robillard and her team, which was comprised of nearly two dozen scientists from across North America, conducted an online survey of 5,525 Canadian during the early phase of the COVID-19 pandemic. She walked us through some of the study’s most important findings.

How has the pandemic affected our sleep?

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Stay in touch with your emotions to reduce pandemic-induced stress

I have written about stress and relaxation numerous times in the past 10 years. The coronavirus has created a variation on that theme.

Everybody, it seems, is stressed out to some degree by the coronavirus pandemic.

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It may be anguish over the sickness or death of a friend or family member. It may be anxiety over a job that has been altered or eliminated. It may be disquiet over the competing demands of work and family while working from home.

These are natural emotions during stressful times, says Emily Kroska, a clinical psychologist at the University of Iowa. The good news, she adds, comes from a new study she led that shows how people might reduce their distress.

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