Category Archives: Alzheimer’s

Memory loss reversed in early Alzheimer’s – Study

Researchers have successfully reversed memory loss in a small number of people with early-stage Alzheimer’s disease using a comprehensive treatment program, which involves a combination of lifestyle changes, brain stimulation, and medication.

Researchers suggest the MEND program is highly effective for reversing memory loss.

2-brain

Memory improvements as a result of the treatment program have so far been sustained for 2 years, the researchers report, and some patients have even been able to return to work as a result.

Study co-author Dr. Dale Bredesen, of the Buck Institute on Research and Aging in Novato, CA, and colleagues recently published their findings in the journal Aging.

While the study only involved 10 patients, the researchers believe their findings may open the door to an effective therapy for cognitive decline.

“The magnitude of improvement in these 10 patients is unprecedented, providing additional objective evidence that this programmatic approach to cognitive decline is highly effective,” says Dr. Bredesen.

There are currently around 5.4 million people in the United States living with Alzheimer’s disease. Continue reading

Advertisements

7 Comments

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, brain, brain damage, brain function, memory, successful aging

Poor sleep habits related to dementia

I have written about the value of sleep for some years here. It along with walking are two of the most unappreciated aspects of living a healthy life. You can check out my Page – How important is a good night’s sleep? for more details.

I wanted to share the following video with you as it highlights another aspect of the value of a good night’s sleep.

Dr. Breus is a clinical psychologist, and is known for his expertise on sleep and health. He’s a fellow of the American Academy of Sleep Medicine,.

Poor sleep literally causes dementia. It’s one of the causes, and fixing it is one of the ways you can reverse dementia.

Dr. Breus explains exactly how lack of sleep affects your body and brain, and how disturbances in your sleep cycles can “turn on” the progression of dementia, and cause many other serious health problems too.

The good news is that you can avoid mental and physical disorders that poor sleep causes by following easy, at-home recommendations Dr. Breus will give you to cure sleep disorders and sleep peacefully all through the night.

Tony

Leave a comment

Filed under Alzheimer's, Alzheimer's disease, Alzheimer's risk, dementia, good night's sleep, sleep, sleep aids, sleep monitors

Music, meditation may improve early cognitive decline – MNT

Meditation and music listening programs have shown promise in improving measures of cognitive and memory in adults with subjective cognitive decline, according to a recent study published in the Journal of Alzheimer’s Disease.

Emerging evidence indicates that subjective cognitive decline (SCD) could represent a pre-clinical stage of Alzheimer’s disease, or unhealthy brain aging. Alzheimer’s disease affects more than 5 million people in the United States.

10880579-Vector-musical-notes-staff-background-for-design-use-Stock-Vector

Dr. Kim Innes, associate professor of epidemiology at West Virginia University in Morgantown, and colleagues aimed to assess the effects of two mind-body practices – Kirtan Kriya meditation and music listening – on cognitive outcomes in people with SCD.

Kirtan Kriya is a form of yoga meditation that combines focused breathing practices, singing or chanting, finger movements, and visualization. Practitioners of yoga claim that this type of meditation stimulates all of a person’s senses and the associated brain areas.

Meditation and music listening programs have shown promise in improving measures of cognitive and memory in adults with subjective cognitive decline, according to a recent study published in the Journal of Alzheimer’s Disease.

Listening to music or taking part in meditation could improve memory and cognitive function among people with SCD.

Continue reading

1 Comment

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, cognitive decline, meditation, music, music therapy, successful aging

Some possibly good news on Alzheimer’s Disease – TED talk

Regular readers know that I have lost three family members to Alzheimer’s Disease and/or dementia. So, anything having to do with those afflictions I find relevant.
This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Brain scientist Owen Carmichael is preparing for his Alzheimer’s diagnosis. And for his children’s Alzheimer’s diagnosis. And he’s asking an important question: Can we use basic health tools to train our brain to resist the effects of the disease?

DR. OWEN CARMICHAEL has a Ph.D. in robotics and a passion for brain science. Owen is an associate professor and the Director of Biomedical Imaging at the Pennington Biomedical Research Center. He uses technology not only to better understand how the wiring of your brain affects your ability to think, but also how your actions and your environment can affect the wiring of the brain. In other words: are we able to set ourselves up to be mentally healthy throughout our lives, or are we destined for our brains to turn our lives one way or another? Owen has been studying these questions for years.

Tony

Leave a comment

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, dementia, successful aging

What about football and the athlete’s brain?

Regular readers know that I have lost three family members to dementia and/or Alzheimer’s disease, so I am totally interested in any new information on the subject. I am also a passionate fan of the National Football League.

The following is from the Alzheimer’s Prevention Bulletin.

by-lemat-works

Most fans will track first downs and touchdowns on Sept. 7, the opening game of the National Football League’s (NFL’s) 2017 season. If he tunes in, Robert Stern, PhD, no doubt will focus on any traumatic brain injuries (TBI) that occur during the game. These can range from mild TBI – as in a concussion – to severe TBI.

Dr. Stern also will watch for those more common head impacts that do not result in symptoms of concussion or draw the attention of the television cameras.  Called “subconcussive” trauma, those hits are associated with a brain disease that is the focus of Dr. Stern’s research.

Dr. Stern is the Director of Clinical Research for the Chronic Traumatic Encephalopathy (CTE) Center and Director of the Alzheimer’s Disease Center Clinical Core, both at Boston University.

“Alzheimer’s disease is my primary focus professionally,” Dr. Stern said. “But some years ago, I started to learn more about another neurodegenerative disease called CTE. I soon realized that CTE had the potential to become a major public health issue. That’s when CTE research became a passion.”

CTE is a progressive, degenerative brain disease, similar to Alzheimer’s disease, found in people with a history of repetitive brain trauma. That brain trauma could include concussions as well as those subconcussive hits to the head that do not have symptoms. The trauma can trigger a series of events in the brain that progressively destroy its tissue, resulting in CTE. The symptoms that accompany CTE are similar to Alzheimer’s disease: changes in memory and cognition as well as changes in mood and behavior. Eventually, it can lead to dementia.

TBI, CTE & Alzheimer’s: Are they Connected? 

Is there a connection between TBI, CTE and Alzheimer’s?

“I used to refer to TBI as a risk factor for Alzheimer’s disease, because early research suggested that,” said Dr. Stern. “However, more recent research suggests that the relationship between the two is not very clear.”

That means people who experience TBI at any age – a hit on the football field as a youth or a fall on the stairs as an older adult – do not appear to increase their chance of developing Alzheimer’s disease.

Concussion Controversies in Sports

Now let’s head back to the football field.

A 2016 Harris Poll showed pro football is continuing its reign as America’s favorite sport. Its popularity persists in spite of concern about the sport’s long-term impact on players’ brain health that began in the early 2000s. At that time, autopsies of deceased American football players revealed evidence of CTE. Years later, research from the BU center published recently in the Journal of the American Medical Association found that 110 out of 111 deceased former NFL players had CTE.

Dr. Stern estimates that in some contact sports like football, there can be 1,000 or more subconcussive hits per season of play. And these impacts can leave their mark on an athlete and eventually lead to CTE.

“There’s research that indicates even after one season of youth football, children ages 8-10 years old,  had structural changes to their brains that were directly associated with the number of hits to the head they received,” Dr. Stern said. “Research from my team at BU has shown a dose-response relationship between the total estimated number of those repetitive head impacts a football player receives through youth, high school, and college football, and later life cognitive impairments and problems with depression and behavior. We have to take these repetitive head impacts seriously.”

And thanks to Dr. Stern, that message is getting out.

Want to learn more about head injury and CTE? Join Dr. Robert A. Stern, PhD, Clinical Core Director of the BU Alzheimer’s Disease Center online as he discusses the role of head injury in developing dementia later in life. 

  • Thursday, August 24th, 2-3 PM Eastern (11 AM-12 PM Pacific / Arizona, 12-1 PM Mountain, 1-2 PM Central)
  • Can’t make it to the live webinar? Don’t worry! Just register as if you will attend and we will send you a recording that you can view at your convenience,
  • Sign up now.

1 Comment

Filed under aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, brain damage, brain function, brain health, dementia, football

Blocking a key enzyme may reverse Alzheimer’s memory loss – MIT study

In the brains of Alzheimer’s patients, many of the genes required to form new memories are shut down by a genetic blockade, contributing to the cognitive decline seen in those patients.

MIT researchers have now shown that they can reverse that memory loss in mice by interfering with the enzyme that forms the blockade. The enzyme, known as HDAC2, turns genes off by condensing them so tightly that they can’t be expressed.

by-lemat-works

For several years, scientists and pharmaceutical companies have been trying to develop drugs that block this enzyme, but most of these drugs also block other members of the HDAC family, which can lead to toxic side effects. The MIT team has now found a way to precisely target HDAC2, by blocking its interaction with a binding partner called Sp3.

“This is exciting because for the first time we have found a specific mechanism by which HDAC2 regulates synaptic gene expression,” says Li-Huei Tsai, director of MIT’s Picower Institute for Learning and Memory and the study’s senior author.

Blocking that mechanism could offer a new way to treat memory loss in Alzheimer’s patients. In this study, the researchers used a large protein fragment to interfere with HDAC-2, but they plan to seek smaller molecules that would be easier to deploy as drugs. Continue reading

2 Comments

Filed under Alzheimer's, Alzheimer's disease, Alzheimer's risk, MIT

To what extent is dementia preventable?

Regular readers know that my family has a history of Alzheimer’s Disease and/or dementia. This is true on both my mother’s and father’s side. So, at 77, I am totally focused on anything that relates to these mental conditions. The following is from the Keck School of Medicine at USC by Erica Rheinschild.

Experts say that one-third of the world’s dementia cases could be prevented by managing lifestyle factors such as hearing loss, hypertension and depression.

 

17-07-2046-Dementia-IG_Final_2-768x576.jpg

This remarkable fact was part of a report by the first Lancet Commission on Dementia Prevention and Care that was presented at the Alzheimer’s Association International Conference (AAIC) 2017 and published in The Lancet. The report also highlighted the beneficial effects of nonpharmacologic interventions such as social contact and exercise for people with dementia. Continue reading

Leave a comment

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, cardio exercise, dementia, Exercise, exercise benefits, successful aging

Could changes in thinking skills be reversible dementia? – Harvard

Regular readers know that I have had a number of Alzheimer’s and dementia occurrences in my immediate family. So, I am especially sensitive to anything related to dementia. The following is from Heidi Godman, Exetutive Editor, Harvard Health Letter.

We use the term “dementia” to describe a number of conditions that cause permanent thinking skills changes, such as memory loss and confusion. The most common kind of dementia is Alzheimer’s disease, which is characterized by clumping proteins that get tangled in and around brain cells, eventually causing them to die. The second most common type of dementia is vascular dementia, caused by decreased blood flow to the brain from atherosclerosis—the accumulation of fatty deposits on artery walls.

c80992a1012118373be3f673cecdf16bf4f6c32b_original

Once dementia strikes, the damage is permanent, and we don’t have many treatment options. So, before a diagnosis is made, it’s crucial to rule out whether the causes for dementia are actually reversible conditions. Continue reading

2 Comments

Filed under aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, brain, brain function, brain health, dementia

What about Alzheimer’s in the family? Harvard

Regular readers know that my family has suffered at least one case of Alzheimer’s and one or two of general dementia. I think it is fair to say that mental illness damages the entire family either directly or indirectly. It also has implications on individuals’ future mental health.

Harvard Medical School offers some fine counseling on the subject.

Alzheimer’s disease represents a personal health crisis, but it’s also a family concern. What does it mean for your children or siblings if you are diagnosed with Alzheimer’s? What does it mean for you if a close relative develops the condition?

100915_fobette-main

“People think that if their dad or aunt or uncle had Alzheimer’s disease, they are doomed. But, no, that’s not true,” says Dr. Gad Marshall, assistant professor of neurology at Harvard Medical School. “Even though family history adds to the overall risk, age still usually trumps it quite a bit. It means your risk is higher, but it’s not that much higher, if you consider the absolute numbers.”

Family history by the numbers

Studies of family history say that if you have a close relative who has been diagnosed with Alzheimer’s disease—the most common form of dementia in older adults—your risk increases by about 30%. This is a relative risk increase, meaning a 30% hike in your existing risk.

Continue reading

5 Comments

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, dementia, successful aging

Extra-virgin olive oil may prevent Alzheimer’s

New research suggests that extra-virgin olive oil – a key component of the Mediterranean diet – may protect the brain from Alzheimer’s disease symptoms. Mouse experiments revealed changes in both cognitive performance and the appearance of nerve cells.

Alzheimer’s disease is estimated to affect approximately 5 million people in the United States. The neurodegenerative disease is progressive and cannot yet be cured or reversed.

2-brain

But new research moves closer to a prevention – and potentially reversing – strategy, by studying the effects of extra-virgin olive oil on the cognitive performance and brain health of mice.

Leave a comment

Filed under Alzheimer's, Alzheimer's disease, olive oil, Uncategorized

Can exercise help people at risk for Alzheimer’s – Study

One of the main goals in living longer is having one’s brain fully functional. Since I have both Alzheimer’s and dementia in my family tree, I am totally focused on keeping my brain working. There is no question that exercise can help one defend against dementia, but with Alzheimer’s the jury is still out.

Can exercise slow or prevent cognitive decline in older people who are at increased risk for Alzheimer’s disease? A new clinical trial led by National Institute on Aging (NIA) -supported scientists in collaboration with the YMCA aims to find out whether exercise may be an effective nondrug treatment for staying cognitively fit.

brainexercise

The trial, called EXERT, will enroll 300 people, age 65 to 89, with mild cognitive impairment (MCI), a condition of mild memory problems that often leads to Alzheimer’s dementia. Based on the trial’s results, the researchers hope to develop an evidence-based “prescription” that will tell people the type and frequency of exercise needed to support memory and thinking skills.

“We want to design a real-life program that can be implemented in the community and prescribed by healthcare providers,” said Laura D. Baker, Ph.D., of Wake Forest Baptist Medical Center in Winston-Salem, N.C., who is leading the study with Carl W. Cotman, Ph.D., of the University of California, Irvine.

Continue reading

Leave a comment

Filed under aging, aging brain, Alzheimer's, Alzheimer's disease, Alzheimer's risk, Exercise, exercise benefits

Women perform better than men on memory tests for Alzheimer’s

Since I have at least three cases of Alzheimer’s or dementia in my family, this kind of information always resonates with me.

Women do better on verbal memory tests commonly used to diagnose Alzheimer’s disease compared to men with the same amount of neurotoxic protein in their brains, a new study has found.

brain-sleep-wake-neurosciencenews-public

It is well known that females have an advantage on verbal memory tests, in which subjects are challenged to recite back a list of heard words. Because women are better at the tests, which are often used to help detect and diagnose Alzheimer’s disease, the severity of their disease may be missed, says Dr. Pauline Maki, professor of psychiatry and psychology at the University of Illinois at Chicago and an author on the study, published in the Journal of Alzheimer’s Disease.

Continue reading

Leave a comment

Filed under Alzheimer's, Alzheimer's disease, dementia

Frequent sauna bathing protects men against dementia

I don’t handle discomfort well, so sitting in a sauna sweating has never appealed to me. Having said that, as regular readers know I have lost three family members to Alzheimer’s or general dementia, so my radar shoots up to high when it comes to impaired cognition.

Frequent sauna bathing can reduce the risk of dementia, according to a recent study carried out at the University of Eastern Finland. In a 20-year follow-up, men taking a sauna 4-7 times a week were 66% less likely to be diagnosed with dementia than those taking a sauna once a week. The association between sauna bathing and dementia risk has not been previously investigated.

benefits-of-visiting-sauna.jpg

The effects of sauna bathing on the risk of Alzheimer’s disease and other forms of dementia were studied in the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD), involving more than 2,000 middle-aged men living in the eastern part of Finland. Based on their sauna-bathing habits, the study participants were divided into three groups: those taking a sauna once a week, those taking a sauna 2-3 times a week, and those taking a sauna 4-7 times a week.

The more frequently saunas were taken, the lower was the risk of dementia. Among those taking a sauna 4-7 times a week, the risk of any form of dementia was 66% lower and the risk of Alzheimer’s disease 65% lower than among those taking a sauna just once a week. The findings were published recently in the Age and Ageing journal.

Previous results from the KIHD study have shown that frequent sauna bathing also significantly reduces the risk of sudden cardiac death, the risk of death due to coronary artery disease and other cardiac events, as well as overall mortality. According to Professor Jari Laukkanen, the study leader, sauna bathing may protect both the heart and memory to some extent via similar, still poorly known mechanisms. “However, it is known that cardiovascular health affects the brain as well. The sense of well-being and relaxation experienced during sauna bathing may also play a role.”

Tony

4 Comments

Filed under Alzheimer's, Alzheimer's disease, dementia, sauna

9  Powerful Eating Habits to Protect Your Brain From Alzheimer’s

This post hit home with my having lost two family members to Alzheimer’s and dementia.

Besides these powerful eating habits, don’t forget the role of exercise in brain health. Check out my Page – Important Facts About Your Brain (and Exercise Benefits).

Tony

Our Better Health

Everything from how you cook meat to what you eat for dessert
can play a role in your brain health.

Here, how to eat to prevent dementia and Alzheimer’s.

by Kenneth S. Kosik, MD

There is no one best dietary pattern when it comes to eating for optimum brain health. Nor is there one magical food or supplement. Instead, a wide range of eating patterns—Asian eating, the MIND diet, the Mediterranean diet, vegan eating—has been shown to protect your brain. Although those eating patterns vary—for example, some include meat, others don’t; some place a heavy emphasis on fish, others suggest no fish—they all tend to have one thing in common: a preponderance of antioxidant-rich plant foods.

Plants manufacture antioxidant chemicals to protect themselves from ultra- violet light and disease. When we eat these plants—in the form of fruits, vegetables, beans, nuts, seeds, and grains—we consume this built-in protection, and their…

View original post 1,309 more words

Leave a comment

Filed under Alzheimer's, diet

10 Ways to Love Your Brain – Alzheimer’s Association

As regular readers know, I am very sensitive to cognitive impairment, having lost two close family members to Alzheimer’s and dementia. So I was very happy to come across this list of recommendations for building up our mental muscles and reducing our chances of contracting Alzheimer’s from the Alzheimer’s Association.

“Research on cognitive decline is still evolving,” said Theresa Hocker, president and CEO of the Alzheimer’s Association – North Central Texas Chapter. “But there are actions people can take. Certain healthy behaviors known to combat cancer, cardiovascular disease and diabetes also may reduce the risk of cognitive decline. These include staying mentally active, engaging in regular physical activity, and eating a heart-healthy diet that benefits your body and your brain.”

1. Break a sweat. Engage in regular cardiovascular exercise that elevates your heart rate and increases blood flow to the brain and body. Several studies have found an association between physical activity and reduced risk of cognitive decline.

2. Hit the books. Formal education in any stage of life will help reduce your risk of cognitive decline and dementia. For example, take a class at a local college, community center or online.

3. Butt out. Evidence shows that smoking increases risk of cognitive decline. Quitting smoking can reduce that risk to levels comparable to those who have not smoked.

4. Follow your heart. Evidence shows that risk factors for cardiovascular disease and stroke – obesity, high blood pressure and diabetes – negatively impact your cognitive health. Take care of your heart, and your brain just might follow.

5. Heads up! Brain injury can raise your risk of cognitive decline and dementia. Wear a seat belt, use a helmet when playing contact sports or riding a bike, and take steps to prevent falls.

6. Fuel up right. Eat a healthy and balanced diet that is lower in fat and higher in vegetables and fruit to help reduce the risk of cognitive decline. Although research on diet and cognitive function is limited, certain diets, including Mediterranean and Mediterranean-DASH (Dietary Approaches to Stop Hypertension), may contribute to risk reduction.

7. Catch some Zzz’s. Not getting enough sleep due to conditions like insomnia or sleep apnea may result in problems with memory and thinking.

8. Take care of your mental health. Some studies link a history of depression with increased risk of cognitive decline, so seek medical treatment if you have symptoms of depression, anxiety or other mental health concerns. Also, try to manage stress.

9. Buddy up. Staying socially engaged may support brain health. Pursue social activities that are meaningful to you. Find ways to be part of your local community – if you love animals, consider volunteering at a local shelter. If you enjoy singing, join a local choir or help at an afterschool program. Or, just share activities with friends and family.

10. Stump yourself. Challenge and activate your mind. Build a piece of furniture. Complete a jigsaw puzzle. Do something artistic. Play games, such as bridge, that make you think strategically. Challenging your mind may have short and long-term benefits for your brain.

“While the adoption of all of these habits is important in influencing brain health, if it seems overwhelming, start with one or two changes and build on them,” Hocker said. “Some changes may be challenging, while others can be fun. Try to choose activities and foods you enjoy.”

I was particularly gratified to see that their first recommendation had to do with getting regular cardiovascular exercise. If you want to read further on this, check out my Page – Important Facts About Your Brain (and Exercise Benefits).

Tony

Leave a comment

Filed under aerobics, Alzheimer's, brain health

7 Ways to Cut Your Alzheimer’s Disease Risk – Infographic

Regular readers know that I have a special sensitivity to Alzheimer’s and dementia as I have lost several family members who were afflicted. There are no guarantees about preventing Alzheimer’s, but this infographic presents some good techiques for reducing your risk. In addition, please check out my Page – Important Facts About Your Brain (and Exercise) for details on how much the brain benefits from exercise.

120ff4395b325fe8070b1941fe75871f

Regarding the first point about saturated fats, organic coconut oil is an exception. Please check out my Page – Coconut Oil – Why You Should Include it in Your Diet. I start every day with a tablespoon of peanut butter dipped in coconut oil.

Tony

Leave a comment

Filed under Alzheimer's, dementia, Exercise