Excessive intake of simple sugar affect higher brain function

Furthermore, by analyzing this model mouse, we aimed to identify the new phenotypes and mechanisms of developing mental disorder. We found “cerebral microvascular angiopathy”. In order to verify the generality of this finding, we used a post-mortem brain from patients with schizophrenia and bipolar disorder, and identified angiopathy similar to the one seen in the model mice. We also found that the angiopathy was accompanied by an impaired glucose incorporation to brain parenchyma in our mice model. These phenotypes were prevented by continuous administration of non-steroidal anti-inflammatory drugs (NSAIDs) before the onset of the disease, and some psychiatric-like symptoms were also suppressed. Notably, the patients used in this study do not necessarily have a record of excessive sucrose intake. They developed psychiatric disorders under various stress circumstances, suggesting that psychiatric disorders are associated with angiopathy in the brain caused by various environmental stresses, including metabolic stress.

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2 responses to “Excessive intake of simple sugar affect higher brain function

  1. This is scary news. My adult daughter has type 1 diabetes and her 4-year-old daughter craves sweet treats. It does affect behavior on alarming ways. Sugar substitutes without bizarre chemicals in them help…monk fruit seems a popular alternative.

    Liked by 1 person

    • Thanks for sharing that. Sugar is definitely something to watch out for, especially in non-alcoholic drinks. Always check the sugar content – remember one teaspoon of sugar = 4 grams. Most people can’t convert grams.

      Liked by 1 person

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