A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis.
A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes. NMN also improved expression of genes that are involved in muscle structure and remodeling. However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice.
The study, published online April 22 in the journal Science, is the first randomized clinical trial to look at the metabolic effects of NMN administration in people.
Among the women in the study, 13 received 250 mg of NMN orally every day for 10 weeks, and 12 were given an inactive placebo every day over the same period.
Regular readers know that I am a big fan of walking. I call it the Cinderella of the exercise world because it is so unappreciated. If you want to learn a lot more about the benefits of walking – after you watch this less than five minute video – check out my Page – Why you should walk more.
I am posting this because it has a ton of good information about eating before working out and working out on an empty stomach. As a matter of fact, I don’t do fasting well, even the short ones, but if this kind of thing works for you, go for it.
The carbs in your stomach digest faster than most other nutrients. Carbs used for energy are digested, flooding your bloodstream with glucose. Your body rapidly secretes insulin, which signals your body to store fat, in two ways: Insulin tells your fat cells to pull in fat from the bloodstream, making you fatter. Insulin tells your fat cells to prevent fatty acids from leaving, preventing you from becoming thinner.
To achieve a healthy weight through weight control or weight loss you need to eat regularly throughout the day.
Medical journalist Michael Mosley demonstrated the effect of skipping breakfast in his show 10 Things You Need to Know to Lose Weight on PBS. He had two MRI brain scans across two days. On the first day he had a full breakfast, on the second, he had no breakfast at all. When he wasn’t hungry, Michael’s brain did not respond much to pictures of either low calorie food like veggies or salads or high calorie foods like sugar caes and fatty chips. However, on the morning he skipped breakfast, his brain buzzed with activity when shown high calorie sugary donuts. Yet he showed far less response to a salad.
So skipping breakfast caused his brain to try to compensate by desiring high calorie foods – clearly a dieting disaster.
When our stomachs empty out, we get a signal to our brain that says, “Feed me!” There is a powerful urge to eat high calorie foods to compensate.
Clearly, this puts unyielding pressure on one’s will power to avoid high calorie foods since your brain is screaming for exactly that. Continue reading →