A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis — the process of cell death that is usually caused by infections and results in excess inflammation in the body — and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.
The discovery, which is reported in Nature Communications, means that scientists have a new way to study diseases that are related to malfunctioning cell death processes, like some cancers, and infections that can be complicated by out-of-control inflammation caused by the process. These infections include sepsis, for example, and acute respiratory distress syndrome, which is among the major complications of COVID-19 illness.
For decades, researchers have probed the link between gum disease and cardiovascular health. Gum disease begins when the sticky, bacteria-laden film dentists refer to as plaque builds up around teeth. A completely different type of plaque — made of fat, cholesterol, calcium, and other substances found in blood — can build up inside arteries. Known as atherosclerosis, this fatty plaque is the hallmark of coronary artery disease.
People with gum disease (also known as periodontal disease) have two to three times the risk of having a heart attack, stroke, or other serious cardiovascular event. But there may not be a direct connection. Many people with heart disease have healthy gums, and not everyone with gum disease develops heart problems. Shared risk factors, such as smoking or an unhealthy diet, may explain the association. Still there’s a growing suspicion that gum disease may be an independent risk factor for heart disease.
The inflammation link
“Periodontal disease increases the body’s burden of inflammation,” says periodontist Dr. Hatice Hasturk of the Harvard-affiliated Forsyth Institute, a not-for-profit research organization focused on oral health. Acute inflammation — which involves an outpouring of immune cells that attack irritants and microbial invaders — fosters healing over the short term. But long-term (chronic) inflammation is a key contributor to many health problems, especially atherosclerosis.
Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge. The researchers say it offers hope for potential new treatments for several types of dementia.
Inflammation is usually the body’s response to injury and stress – such as the redness and swelling that accompanies an injury or infection. However, inflammation in the brain – known as neuroinflammation – has been recognized and linked to many disorders including depression, psychosis and multiple sclerosis. It has also recently been linked to the risk of Alzheimer’s disease.
In a study published in the journal Brain, a team of researchers at the University of Cambridge set out to examine whether neuroinflammation also occurs in other forms of dementia, which would imply that it is common to many neurodegenerative diseases.
Study shows Plaque HD® significantly reduces inflammation throughout the body
For decades, researchers have suggested a link between oral health and inflammatory diseases affecting the entire body — in particular, heart attacks and strokes. Inflammation is intimately involved in the pathogenesis of atherosclerosis and is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future risks of heart attacks and strokes.
Researchers from Florida Atlantic University’s Schmidt College of Medicine, Marshfield Clinic Research Institute, and the University of Wisconsin School of Medicine and Public Health, collaborated on a randomized trial titled, “Correlation between Oral Health and Systemic Inflammation” (COHESION), to further explore whether Plaque HD®, a plaque identifying toothpaste, reduces hs-CRP. Continue reading →
I have to admit that I have been seeing items and ads about CoQ10 for years and never paid it much attention. I stumbled across this rundown in Medical News Today and was amazed at its functionality. I thought it would interest you.
CoQ10 is an antioxidant that exists in almost every cell of the human body. CoQ10 deficiency is associated with various medical conditions, such as heart disease, cancer, and Alzheimer’s disease.
Although the body naturally produces CoQ10, some people may benefit from taking supplements. Overall, CoQ10 supplements appear relatively safe and cause few side effects. Supplements are not regulated by the Food and Drug Administration (FDA) for purity or verified for labeling accuracy, so purchase only those products that have been tested by an independent lab.
People who are interested in trying CoQ10 supplements may want to consult a healthcare professional first. Experts do not recommend CoQ10 for people taking blood-thinning medications, insulin, or certain chemotherapy drugs.Continue reading →
As if we didn’t have enough to worry about with our penchant for carrying too much weight, researchers using MRI have found signs of damage that may be related to inflammation in the brains of obese adolescents, according to a study being presented next week at the annual meeting of the Radiological Society of North America (RSNA).
Obesity in young people has become a significant public health problem. In the U.S., the percentage of children and adolescents affected by obesity has more than tripled since the 1970s, according to the Centers for Disease Control and Prevention. Data from the World Health Organization indicates that the number of overweight or obese infants and young children ages five years or younger increased from 32 million globally in 1990 to 41 million in 2016.
Reduction in fractional anisotropy (FA) in obese patients compared to the control group: At the intersection of the alignment vectors, a large cluster of FA decrease located in the corpus callosum on the left. In red: Reduction of FA in obese patients compared to controls, and FA skeleton (green), superimposed on the mean of FA images in sample. The image is credited to Study author and RSNA.
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
An estimated 12M UK citizens have a chronic medical condition, and many of them report severe mental fatigue that they characterize as ‘sluggishness’ or ‘brain fog’. This condition is often as debilitating as the disease itself.
A team in the University’s Center for Human Brain Health investigated the link between this mental fog and inflammation – the body’s response to illness. In a study published in Neuroimage, they show that inflammation appears to have a particular negative impact on the brain’s readiness to reach and maintain an alert state.
Dr Ali Mazaheri and Professor Jane Raymond of the University’s Centre for Human Brain Health, are the senior authors of the study. Dr Mazaheri says: “Scientists have long suspected a link between inflammation and cognition, but it is very difficult to be clear about the cause and effect. For example, people living with a medical condition or being very overweight might complain of cognitive impairment, but it’s hard to tell if that’s due to the inflammation associated with these conditions or if there are other reasons.” Continue reading →
I am a chocolate lover. I have some every day of my life. Granted, what I consume are small quantities which I devour slowly and let simply melt in my mouth. I also know that dark chocolate has more benefits than the sweet milk chocolate of my childhood. Herewith, Medical News Today‘s take on the dark delight.
Chocolate lovers, rejoice; the sweet treat is not only delicious, but studies show that it can also promote friendly bacteria and reduce inflammation in our guts. But first, some background: trillions of bacteria live in our guts. They contribute to our immune system, metabolism, and many other processes essential to human health.
When the delicate balance of microbes in our intestines is disturbed, it can have serious consequences.
Running may also slow the process that leads to osteoarthritis
As regular readers know, I ride my bike nearly daily, here in Chicago. A hundred years ago, it seems, I ran daily. I stopped running because I enjoy bike riding more.
We all know that running causes a bit of inflammation and soreness, and that’s just the price you pay for cardiovascular health. You know; no pain, no gain.
Well, maybe not. New research from BYU exercise science professors finds that pro-inflammatory molecules actually go down in the knee joint after running.
In other words, it appears running can reduce joint inflammation.“It flies in the face of intuition,” said study coauthor Matt Seeley, associate professor of exercise science at BYU. “This idea that long-distance running is bad for your knees might be a myth.” Continue reading →
I am a coffee drinker in moderation, so I only worry about the effects of caffeine on me. I have heard horror stories of ‘caffeine headaches’ that die hard coffee drinkers get. So I pretty much limit myself to decaf. I was happy to learn the latest from Harvard on coffee drinking.
People who drink about three to five cups of coffee a day may be less likely to die prematurely from some illnesses than those who don’t drink or drink less coffee, according to a new study by Harvard T.H. Chan School of Public Health researchers and colleagues. Drinkers of both caffeinated and decaffeinated coffee saw benefits, including a lower risk of death from cardiovascular disease, neurological diseases, type 2 diabetes, and suicide.
“Bioactive compounds in coffee reduce insulin resistance and systematic inflammation,” said first author Ming Ding, a doctoral student in the Department of Nutrition. “That could explain some of our findings. However, more studies are needed to investigate the biological mechanisms producing these effects.”
What seems like a hundred years ago, I was a young reporter on the floor of the Chicago Mercantile Exchange covering, among other markets, the Shell Egg Futures market. As a result I daily came in contact with folks in the egg industry. I started eating eggs regularly and my health did not suffer in any way. If you want to read further about the benefits of eating eggs, check out this post: Is it Healthy to Eat Eggs Regularly?
Foods are a wonderful place to start when you are looking to reduce inflammation in your body. What you eat on a daily basis will have a profound effect on your body’s ability to fight inflammation and prevent inflammation from happening. Through eating you literally change the chemistry of your body.
Inflammation can be caused many different factors. Scientifically speaking inflammation is a cascade of chemical reactions that happen within the body when there is damage done to cells, when there is an irritant present or when the body senses a foreign invader.
What Are The Symptoms Of Acute Inflammation?
The inflammation reaction is necessary and protective for the body in the short-term. Acute inflammation can leave you with the following cluster of symptoms: pain, redness, immobility, swelling and heat. This is due to the fact that large amounts of both red and white blood cells, lipoproteins, fluid and other body tissues are rushing to the site of injury in an attempt to repair damage and clear away foreign particles.
So What Is The Problem With Inflammation?
The problem with inflammation comes when it is prolonged or becomes chronic. It is meant to be a “first…
While inflammation is a protector of our health when it’s an acute response, chronic inflammation is a different story. A diverse group of medical illness are believed to be caused in part by chronic activation of the same chemical and cellular processes described above. These include asthma, acne, celiac disease, rheumatoid arthritis, and even atherosclerosis of heart arteries. In fact, in 1856 Rudolf Virchow proposed that arterial disease was an inflammation of blood vessels and now, over 150 years later, people who fear heart disease are routinely checked for this process.
Please check out A Beginner’s Guide to Earthing (Grounding) – Part One. I have been practicing Earthing since July and it definitely reduces inflammation in the body. It is like taking an antioxidant shower.
Regular readers of MindBodyGreen are aware that a process in our bodies called inflammation is involved in many aspects of human health and disease. For example, you may have read that a breakfast of Egg McMuffins, sleep apnea, obesity and ultra-exercise are inflammatory, while turmeric, meditation and the Mediterranean diet are anti-inflammatory, and so on. Lost in the search for vitality and longevity is an understanding of what inflammation is and what can be done to tame it. In many ways, inflammation is a Goldilocks process – you don’t want too much or too little, but just the right amount.
When I explain inflammation to patients, I point out that the middle of the word is “flame,” and that it comes from the Latin “I ignite.” Inflammation is a complex process of cells and chemicals in our bodies standing ready to fight…
Regular readers know that watermelon is one of my favorite foods in the world. Although I live in a four season city – Chicago, I am able to eat watermelon year ’round because I have access to some good grocers who get it from Mexico in the winter. I eat watermelon every time I ride my bike because it replenishes my energy – besides tasting wonderful! It’s a party in my mouth.
“Our data suggest vitamin D may be involved in maintaining the health of the immune system as well as the skeletal system,” said one of the study’s authors, Mary Ward, PhD, of the University of Ulster in Coleraine, U.K. “This study is the first to find a connection between vitamin D levels and inflammation in a large sample of older individuals.”
Vitamin-deficient seniors more likely to have biomarkers for heart disease, inflammation
Older individuals who are vitamin D deficient also tend to have compromised immune function, according to new research accepted for publication in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
Vitamin D plays an important role in helping the body absorb calcium needed for healthy bones. The skin naturally produces vitamin D when it is exposed to sunlight. People also obtain smaller amounts of the vitamin through foods, such as milk fortified with vitamin D. More than 1 billion people worldwide are estimated to have deficient levels of vitamin D due to limited sunshine exposure.
“Our data suggest vitamin D may be involved in maintaining the health of the immune system as well as the skeletal system,” said one of the study’s authors, Mary Ward, PhD, of the University of Ulster in Coleraine, U.K. “This study is…