Tag Archives: genetics

Beyond genes and environment, random variations play important role in longevity

A new model of aging takes into account not only genetics and environmental exposures but also the tiny changes that randomly arise at the cellular level.

University Professor Caleb Finch introduced the “Tripartite Phenotype of Aging” as a new conceptual model that addresses why lifespan varies so much, even among human identical twins who share the same genes. Only about 10 to 35 percent of longevity can be traced to genes inherited from our parents, Finch mentioned.

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Finch authored the paper introducing the model with one of his former graduate students, Amin Haghani, who received his PhD in the Biology of Aging from the USC Leonard Davis School in 2020 and is now a postdoctoral researcher at UCLA. In the article, they propose that the limited heritability of aging patterns and longevity in humans is an outcome of gene-environment interactions, together with stochastic, or chance, variations in the body’s cells. These random changes can include cellular changes that happen during development, molecular damage that occurs later in life, and more.

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Genetic variants cut Alzheimer’s disease risk – UCL

While there is no known ‘silver bullet’ for Alzheimer’s disease it appears that there may be some ‘luck of the draw’ genetic variants that help.

A DNA study of over 10,000 people by University College of London (UCL) scientists has identified a class of gene variants that appear to protect against Alzheimer’s disease.

The findings, published in Annals of Human Genetics, suggest these naturally occurring gene variants reduce the functioning of proteins called tyrosine phosphatases, which are known to impair the activity of a cell signalling pathway known as PI3K/Akt/GSK-3β. This pathway is important for cell survival.

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The research builds on previous studies in mice and rats, which suggested inhibiting the function of these proteins might be protective against Alzheimer’s disease, but this is the first time such an effect has been demonstrated in people.

Researchers believe the PI3K/Akt/GSK-3β signalling pathway could be a key target for therapeutic drugs and the findings also strengthen evidence that other genes could be linked to either elevated or reduced risk of Alzheimer’s disease.

“These results are quite encouraging. It looks as though when naturally-occurring genetic variants reduce the activity of tyrosine phosphatases then this makes Alzheimer’s disease less likely to develop, suggesting that drugs which have the same effect might also be protective,” said the study’s lead author, Professor David Curtis (UCL Genetics Institute).

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Filed under Alzheimer's, Alzheimer's disease, dementia, DNA, genetics