Having lost three family members to Alzheimer’s Disease and dementia, I was fascinated by this information from researchers in Berlin.
A study led by researchers at the Hospital del Mar Medical Research Institute (IMIM) and the Institute of Medical Physics and Biophysics at the Faculty of Medicine in Charité Hospital, Berlin, published in the journal Nature Communications, demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer’s.
The adenosine receptor belongs to the GPCR family (G Protein-Coupled Receptors), a large group of proteins located in cell membranes, which are key in the transmission of signals and communication between cells. GPCRs are therefore involved in the majority of important physiological processes, including the interpretation of sensory stimuli such as vision, smell, and taste, the regulation of the immune and inflammatory system, and behavior modulation. Continue reading
I write often about the benefits the brain gets from exercise and how we should make regular exercise a priority as much for our mental health as physical. That is a good positive target.
It turns out that WebMD also has some excellent suggestions for keeping our brains clicking on all cylinders, but they approach from the negative side. Not doing harmful things is also an important consideration in getting to old age with a fully functional brain.
Here is their list of bad habits:
Missing out on sleep. WebMD notes, “… lack of sleep may be a cause of dementia, including Alzheimer’s disease. It’s best to have regular sleeping hours. If you have trouble with sleep, avoid alcohol, caffeine, and electronics in the evening, and start a soothing bedtime ritual.”
I would like to interject here that my Page on How important is a good night’s sleep could be worth checking into. Continue reading
Because both Alzheimer’s and dementia run in my family, I am acutely aware of my own brain health as well as anything that might be damaging to it.
On the positive side, check out my Page Important Facts About Your Brain (and Exercise Benefits) as well as Important Facts About Brain Fitness.
The final item names smoking. To learn more about the damage smoking does to your body and your general health, check out my Page How Many Ways Does Smoking Harm You?
In the last week of September, older adults find plenty of interesting things to do and learn during Active Aging Week, The International Council on Active Aging’s (ICAA) annual health promotion event.
In senior centers and retirement communities, parks and health clubs, nature preserves and dance halls, Active Aging Week hosts provide many opportunities to choose an active life:
• Healthy lifestyle presentations for diabetes, arthritis, depression and other conditions
• Nutrition and lifestyles presentations
• Brain fitness and healthy mental outlooks
• Health and fitness assessments
• Concerts, singalongs, dancing
• Group exercise, strength training,Tai chi and yoga
• Games and challenges
• Strolls and walks
• Health fairs, referrals, government programs
• Free food, prizes, coupons, pedometers and t-shirts
As our regular readers appreciate we fully support this effort to engage seniors in healthy activities. Please see what events are available in your area.
Eat less; move more.