Category Archives: living longer

Gain years keeping heart disease at bay – AHA

Heart disease is the nation’s No. 1 cause of death, killing about 650,000 people every year. Life expectancy is cut short by the disease and the health problems that stem from it. But by how much – and what can people do to take those years back?

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For heart attacks alone, more than 16 years of life are lost on average, according to American Heart Association statistics. Researchers estimate people with heart failure lose nearly 10 years of life compared to those without heart failure.

“In the past few years, there have been tremendous gains in reducing cardiovascular disease and increasing life expectancy, but we’ve hit a plateau,” said Paul Muntner, an epidemiologist at the University of Alabama at Birmingham.

Some people are at greater risk than others.

African Americans, for example, are more likely to have high blood pressure, obesity and diabetes, and they live 3.4 years less than their white counterparts. Among the six largest Asian American subgroups, research shows Asian Indian, Filipino and Vietnamese populations lose the most years of life to heart disease – up to 18 years for some – compared with white people.

The risk of early death also is high for people with a history of diabetes, stroke and heart attack. Reporting in the Journal of the American Medical Association in 2015, researchers found people with all three conditions had their life expectancy cut by 15 years compared to those without any of the health problems. Even having just two of the conditions reduced life expectancy by 12 years.

But there is hope. Continue reading

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Growth hormone, athletic performance, and aging – Harvard

Can human growth hormones really benefit aging, like the elusive fountain of youth? In 1513, the Spanish explorer Juan Ponce de Len arrived in Florida to search for the fountain of youth. If he got any benefit from his quest, it was due to the exercise involved in the search.

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Few men today believe in miraculous waters, but many, it seems, believe in the syringe of youth. Instead of drinking rejuvenating waters, they inject human growth hormone to slow the tick of the clock. Some are motivated by the claims of the “anti-aging” movement, others by the examples of young athletes seeking a competitive edge. Like Ponce de Len, the athletes still get the benefit of exercise, while older men may use growth hormone shots as a substitute for working out. But will growth hormone boost performance or slow aging? And is it safe?

What is human growth hormone?

Growth hormone (GH) is a small protein that is made by the pituitary gland and secreted into the bloodstream. GH production is controlled by a complex set of hormones produced in the hypothalamus of the brain and in the intestinal tract and pancreas. Continue reading

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Push-ups and heart health – Harvard

Active, middle-aged men able to complete more than 40 push-ups had a significantly lower risk of cardiovascular disease (CVD) outcomes—including diagnoses of coronary artery disease and major events such as heart failure—during 10 years of follow-up compared with those who were able to do less than 10 push-ups during the baseline exam.

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“Our findings provide evidence that push-up capacity could be an easy, no-cost method to help assess cardiovascular disease risk in almost any setting. Surprisingly, push-up capacity was more strongly associated with cardiovascular disease risk than the results of submaximal treadmill tests,” said first author Justin Yang, occupational medicine resident in the Department of Environmental Health at Harvard T.H. Chan School of Public Health.

The study was published February 15, 2019 in JAMA Network Open.

Objective assessments of physical fitness are considered strong predictors of health status; however, most current tools such as treadmill tests are too expensive and time-consuming to use during routine exams. This is the first known study to report an association between push-up capacity and subsequent cardiovascular disease outcomes.

The researchers analyzed health data from 1,104 active male firefighters collected from 2000 to 2010. Their mean age was 39.6 and mean body mass index (BMI) was 28.7. Participants’ push-up capacity and submaximal treadmill exercise tolerance were measured at the start of the study, and each man subsequently completed annual physical examinations and health and medical questionnaires.

During the 10-year study period, 37 CVD-related outcomes were reported. All but one occurred in men who completed 40 or fewer pushups during the baseline exam. The researchers calculated that men able to do more than 40 push-ups had a 96% reduced risk of CVD events compared with those who were able to do less than 10 push-ups. Push-up capacity was more strongly associated with lower incidence of cardiovascular disease events than was aerobic capacity as estimated by a submaximal treadmill exercise test.

Because the study population consisted of middle-aged, occupationally active men, the results may not be generalizable to women or to men of other ages or who are less active, note the authors.

“This study emphasizes the importance of physical fitness on health, and why clinicians should assess fitness during clinical encounters,” said senior author Stefanos Kales, professor in the Department of Environmental Health at Harvard Chan School and chief of occupational medicine at Cambridge Health Alliance.

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5 Life skills aid longevity – Study

Life skills, such as persistence, conscientiousness and control, are as important to wealth and well being in later life as they are when people are much younger, according to new research led by University College of London (UCL).

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Five life skills – emotional stability, determination, control, optimism and conscientiousness – play a key role in promoting educational and occupational success in early life but little has been known about their importance in later life. Continue reading

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Mini workouts boost your health – Harvard

As an old retired guy, I don’t have much time pressure in my life these days, but I remember how imposing work,  family and social obligations can be on your schedule. Don’t let that keep you from working on living a healthy life.  As Harvard says in this Women’s Healthwatch post, it all counts.

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Good news for people who struggle to find time for exercise: every little bit matters, even if your “workout” is broken up throughout the day. To come to this conclusion, researchers who published their results March 23 in the Journal of the American Heart Association looked at data from 4,840 people ages 40 and older who participated in the National Health and Nutrition Examination Survey from 2003 to 2006. People who spent the shortest amount of time in moderate or vigorous activity — 20 minutes or less daily — had the highest risk of dying during the roughly six-year follow-up period. But those who got at least an hour of moderate or vigorous activity cut that risk in half, and those who got at least 100 minutes a day cut their death risk by 76%. And they didn’t have to get those 100 minutes all at once. Even short bursts of activity at different points in the day added up to reduced risk.

According to the U.S. Dept of Health and Human Services:

Adults 18 to 64 should get:
2.5 hours/wk of moderate intensity exercise.
OR 1.25 hours a week of vigorous aerobic physical activity
Or Some combination of the above – equivalent episodes of at least 10 minutes spread throughout the week.

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You don’t have to be ‘strictly vegetarian’ to reap the benefits

For the record, I was a vegetarian for five years in my middle 30’s. At the time I did yoga daily and lived a generally active lifestyle. I weighed around 150 pounds and felt great. I stopped my vegetarianism mainly for social reasons. I felt guilty telling a hostess that I didn’t eat meat and needed different food. These days, I do eat red meat, but very sparingly. I am very conscious of the bad fats and am concerned about clogging up my arteries in my old age. As it turns out, I am eating according to the guidelines of this study from Erasmus University Medical Center in the Netherlands.

According to new data, a diet rich in plant-based foods and low in meat — without strictly following a vegetarian or vegan diet — may offer protection against obesity in middle-aged and older adults.

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Experts already know that diets that emphasize plant-based over animal-based foods — such as vegetarian or vegan diets — can decrease the risk of obesity.

However, scientists do not yet know how strictly these diets need to be followed to reduce the risk of becoming overweight or obese later in life. Continue reading

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Increase life expectancy a decade with these five healthy habits – Harvard

Who doesn’t want to live longer? I am impressed every day by the number of much younger followers I am getting on this blog.  Herewith Harvard’s latest on living longer..

Maintaining five healthy habits—eating a healthy diet, exercising regularly, keeping a healthy body weight, not drinking too much alcohol, and not smoking—during adulthood may add more than a decade to life expectancy, according to a new study led by Harvard T.H. Chan School of Public Health.

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Researchers also found that U.S. women and men who maintained the healthiest lifestyles were 82% less likely to die from cardiovascular disease and 65% less likely to die from cancer when compared with those with the least healthy lifestyles over the course of the roughly 30-year study period. Continue reading

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Night Owls Have Higher Risk of Dying Sooner – Study

I started taking courses in various aspects of good health and nutrition back eight years ago when I first started working on this blog. I created the Page – How important is a good night’s sleep? in 2013, so regular readers have been hearing about that aspect of good health since at least then. Here, we have a fresh insight into sleep habits that adds to the import of it.

A new study reports being a night owl might have significant consequences for your health, including an increased risk of dying earlier.

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“Night owls” — people who like to stay up late and have trouble dragging themselves out of bed in the morning — have a higher risk of dying sooner than “larks,” people who have a natural preference for going to bed early and rise with the sun, according to a new study from Northwestern Medicine and the University of Surrey in the United Kingdom (UK).

The study, on nearly half a million participants in the UK Biobank Study, found owls have a 10 percent higher risk of dying than larks. In the study sample, 50,000 people were more likely to die in the 6½ -year period sampled.

“Night owls trying to live in a morning lark world may have health consequences for their bodies,” said co-lead author Kristen Knutson, associate professor of neurology at Northwestern University Feinberg School of Medicine. Continue reading

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Some insights into weight and aging – Web MD

I love these WebMD quizzes. I thought this was a particularly germane one for us.

There are only nine questions, but I want to offer a couple of sample. You can take the quiz here.

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I only missed a couple (wheew!). Since I have been writing this blog for nearly 10 years, I expected to crush it.

Here are a couple of examples:

True or False – Thinner is better as you get older. Unlike the majority of our lives, things change as we age. The answer is, “You want to be healthy, not frail. For older adults, what matters most is how active you are and whether you can do all your everyday activities. While it’s important to stay at a healthy weight, how much of your weight ”

I thought that was an excellent insight which many people would not know.

True or False. Gaining weight is a fact of aging. This one is also not obvious. “You can keep your weight steady as you age. It does get harder, but it’s possible. Those corners you cut when you were younger (huge portions, happy hours, little to no exercise)? You can’t   But age doesn’t have to equal weight gain.”

I must admit that the statement, You can’t get away with them anymore, is, I think, no secret to any of us over 50.

Tony

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How to age more slowly

Here is further information on the goal and idea of living a long life with a functioning brain throughout.

Tony

True Strange Library

Centenarians reach age 100 because they age more slowly. Genetics play a part in resisting damage that accumulatesover time, but there are things anyone can do to slow the aging process and improve health.

According to Israeli physician Nir Barzilai of the Institute for Aging Research at Albert Einstein College of Medicine in New York:

“There is no pattern. The usual recommendations for a healthy life — not smoking, not drinking, plenty of exercise, a well-balanced diet, keeping your weight down — they apply to us average people. But not to them. Centenarians are in a class of their own.” …

“Today’s changes in lifestyle do in fact contribute to whether someone dies at the age of 85 or before age 75.

But in order to reach the age of 100, you need a special genetic make-up. These people age differently. Slower. They end up dying of the same diseases…

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Owning A Dog Is Good For Your Heart — Study Says What We All Knew

As a dog lover and owner I had to share this one with you along with a picture of my little canine companion who turns 12 next month.

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This is Gabi, who rides on the bike with me.

Tony

Our Better Health

It seems unconditional love from a fluffy, drooling canine is one key to a healthier life — as many people already expected.

A study of more than 3.4-million people revealed that having a dog in the house is linked to living a longer life. The research, published in Scientific Reports by Uppsala University in Sweden, reviewed a national registry of people aged 40 to 80 for up to 12 years. Just over 13 per cent were dog owners.

By evaluating health records, it found that registered dog owners had a lower risk of having heart attacks and other life-threatening conditions. It said owning a dog cuts down the risk of death from cardiovascular disease by 36 per cent for people that live alone.

There is a slightly lower benefit to owning a canine for those who don’t live alone — the risk was cut by only 15 per cent. Researchers…

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Amish have internal ‘fountain of youth’ – Study

The first genetic mutation that appears to protect against multiple aspects of biological aging in humans has been discovered in an extended family of Old Order Amish living in the vicinity of Berne, Indiana, report Northwestern Medicine scientists.

An experimental “longevity” drug that recreates the effect of the mutation is now being tested in human trials to see if it provides protection against some aging-related illnesses.

Indiana Amish kindred (immediate family and relatives) with the mutation live more than 10 percent longer and have 10 percent longer telomeres (a protective cap at the end of our chromosomes that is a biological marker of aging) compared to Amish kindred members who don’t have the mutation, reports the new Northwestern study. (my emphasis)

Amish with this mutation also have significantly less diabetes and lower fasting insulin levels. A composite measure that reflects vascular age also is lower — indicative of retained flexibility in blood vessels in the carriers of the mutation — than those who don’t have the mutation, the research also found.

The paper was published Nov. 15 in the journal Science Advances.

These Amish individuals have very low levels of PAI-1 (plasminogen activator inhibitor,) a protein that comprises part of a “molecular fingerprint” related to aging or senescence of cells. It was previously known that PAI-1 was related to aging in animals but unclear how it affected aging in humans.

“The findings astonished us because of the consistency of the anti-aging benefits across multiple body systems,” said Dr. Douglas Vaughan, the lead author of the paper who has been studying PAI-1 for almost 30 years.

Vaughan, a cardiologist, is the Irving S. Cutter Professor and chairman of medicine at Northwestern University Feinberg School of Medicine and Northwestern Medicine.

“For the first time we are seeing a molecular marker of aging (telomere length), a metabolic marker of aging (fasting insulin levels) and a cardiovascular marker of aging (blood pressure and blood vessel stiffness) all tracking in the same direction in that these individuals were generally protected from age-related changes,” Vaughan said. “That played out in them having a longer lifespan. Not only do they live longer, they live healthier. It’s a desirable form of longevity. It’s their ‘health span.’”

“Longevity” drug developed by Northwestern and Tohoku University

Northwestern has partnered with Tohoku University in Japanin the development and testing of an oral drug, TM5614, that inhibits the action of PAI-1. The drug has already been tested in a phase 1 trial in Japan and is now in phase 2 trials there. Northwestern will apply for FDA approval to start an early phase trial in the U.S., possibly to begin within the next six months.

The proposed Northwestern trial will investigate the effects of the new drug on insulin sensitivity on individuals with type 2 diabetes and obesity because of the mutation’s effect on insulin levels in the Amish.

A mutation confers longevity

In the new study, Northwestern scientists looked at individuals who had one mutant copy of the gene, rendering their level of PAI-1 about half the level of kindred with two normal copies. Continue reading

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Exercise can make cells healthier, promoting longer life – Study

Eat less, more more; live longer remains the mantra of this blog. Now comes MedicalPress with a study confirming the move more segment.

Whether it’s running, walking, cycling, swimming or rowing, it’s been well-known since ancient times that doing some form of aerobic exercise is essential to good health and well-being. You can lose weight, sleep better, fight stress and high blood pressure, improve your mood, plus strengthen bones and muscles.

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“Whether muscle is healthy or not really determines whether the entire body is healthy or not,” said Zhen Yan of the University of Virginia School of Medicine. “And exercise capacity, mainly determined by muscle size and function, is the best predictor of mortality in the general population.”

But why? Yan might have some answers. He and colleagues at UVA are peering inside the cell to understand, at a molecular level, why that workout – like it or not – is so vital to the body. They found that one important benefit involves the cellular power plant – the mitochondria – which creates the fuel so the body can function properly.

 

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Reaction time variation may predict mortality in old age – Study

A common indicator of neurobiological disturbance among the elderly may also be associated with mortality, according to a study published August 9, 2017 in the open access journal PLOS ONE by Nicole A. Kochan at the Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney.

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Intraindividual reaction time variability (IIVRT), defined as an individual’s variation in reaction times when completing a single cognitive task across several trials, has been associated with mild cognitive decline, dementia and Parkinson’s disease. The authors of this study investigated whether IIVRT is also associated with mortality in old age by following a cohort of 861 adults aged 70 years to 90 years over an eight-year period.

Kochan and colleagues tested the participants’ baseline reaction time by having them complete two brief computerized cognitive tasks comprising 76 trials to measure the average reaction time and the extent of variation over the trials. Every two years, research psychologists followed up on the participants and conducted a comprehensive medical assessment including a battery of neuropsychological tests to assess the participants’ cognitive function. Cases were also reviewed by a panel of experts to determine a dementia diagnosis in each two year follow-up, and mortality data was collected from the state registry.

Study results indicate that greater IIVRT predicted all-cause mortality, but the average RT did not predict time to death. Researchers found that other risks factors associated with mortality such as dementia, cardiovascular risk and age could not explain the association between IIVRT and mortality prediction. The authors suggested that IIVRT could therefore be an independent predictor of shorter time death.

“The study was the first to comprehensively account for effects of overall cognitive level and dementia on the relationship between intraindividual variability of reaction time and mortality,” says Kochan. “Our findings suggest that greater intraindividual reaction time variability is a behavioural marker that uniquely predicts shorter time to death.”

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Does coffee help you live longer?

I love my morning coffee. I also love a cup of cappuccino after dinner when dining out, so, clearly I have a dog in this fight.

Scientists have found that people who drink coffee appear to live longer.

Drinking coffee was associated with a lower risk of death due to heart disease, cancer, stroke, diabetes, and respiratory and kidney disease for African-Americans, Japanese-Americans, Latinos and whites.

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People who consumed a cup of coffee a day were 12 percent less likely to die compared to those who didn’t drink coffee. This association was even stronger for those who drank two to three cups a day—18 percent reduced chance of death.

Lower mortality was present regardless of whether people drank regular or decaffeinated coffee, suggesting the association is not tied to caffeine, said Veronica W. Setiawan, lead author of the study and an associate professor of preventive medicine at the Keck School of Medicine of USC. Continue reading

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7 Simple suggestions to live longer – AHA

Living past 100 is no walk in the park, although including one can prove very helpful. The American Heart Association has created this list with the goal of improved health by educating the public on how best to live longer and healthier.

These measures have one unique thing in common: any person can make these changes, the steps are not expensive to take and even modest improvements to your health will make a big difference. Start with one or two. This simple, seven step list has been developed to deliver on the hope we all have–to live a long, productive healthy life. 

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Manage Blood Pressure
High blood pressure is a major risk factor for heart disease and stroke. When your blood pressure stays within healthy ranges, you reduce the strain on your heart, arteries, and kidneys which keeps you healthier longer.
Learn how to manage your blood pressure. Continue reading

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