Getting a consistent good night’s sleep supports normal production and programming of hematopoietic stem cells, a building block of the body’s innate immune system, according to a small National Institutes of Health-supported study in humans and mice. Sleep has long been linked to immune function, but researchers discovered that getting enough of it influenced the environment where monocytes – a type of white blood cell – form, develop, and get primed to support immune function. This process, hematopoiesis, occurs in the bone marrow.
“What we are learning is that sleep modulates the production of cells that are the protagonists – the main actors – of inflammation,” said Filip K. Swirski, Ph.D., a senior study author and director of the Cardiovascular Research Institute at Icahn School of Medicine at Mount Sinai, New York City. “Good, quality sleep reduces that inflammatory burden.”
A Stanford Medicine study that dug into two types of common digestive fiber supplements showed stark differences in how we react to them, and it’s not always good.
The study also revealed insights into how one type of fiber reduces cholesterol — a mystery scientists have been chasing for years.
“We all know that high-fiber diets are good for us, but published reports of their effects can be highly contradictory,” said Michael Snyder, PhD, professor and chair of genetics and the senior author of the study, which was published April 28 in Cell Host & Microbe.
Snyder, the Stanford W. Ascherman, MD, FACS, Professor in Genetics, and his colleagues monitored thousands of molecules involved in metabolism and the microbiome, tracking the ebb and flow of the molecules as healthy volunteers ingested different amounts of two common dietary fibers — inulin and arabinoxylan.
The results showed that while arabinoxylan was overall a boon for reducing “bad” cholesterol, high doses of inulin caused a spike in inflammation in some people. There was, however, one volunteer whose body reacted well to high doses of inulin but not arabinoxylan. “Overall, this study revealed the effects of common fibers on human health and suggests strategies for personalized dietary interventions,” Snyder said.
A study published by researchers at the University of Illinois Chicago describes a new method for analyzing pyroptosis — the process of cell death that is usually caused by infections and results in excess inflammation in the body — and shows that process, long thought to be irreversible once initiated, can in fact be halted and controlled.
The discovery, which is reported in Nature Communications, means that scientists have a new way to study diseases that are related to malfunctioning cell death processes, like some cancers, and infections that can be complicated by out-of-control inflammation caused by the process. These infections include sepsis, for example, and acute respiratory distress syndrome, which is among the major complications of COVID-19 illness.
Inflammation in the brain may be more widely implicated in dementias than was previously thought, suggests new research from the University of Cambridge. The researchers say it offers hope for potential new treatments for several types of dementia.
Inflammation is usually the body’s response to injury and stress – such as the redness and swelling that accompanies an injury or infection. However, inflammation in the brain – known as neuroinflammation – has been recognized and linked to many disorders including depression, psychosis and multiple sclerosis. It has also recently been linked to the risk of Alzheimer’s disease.
In a study published in the journal Brain, a team of researchers at the University of Cambridge set out to examine whether neuroinflammation also occurs in other forms of dementia, which would imply that it is common to many neurodegenerative diseases.
Study shows Plaque HD® significantly reduces inflammation throughout the body
For decades, researchers have suggested a link between oral health and inflammatory diseases affecting the entire body — in particular, heart attacks and strokes. Inflammation is intimately involved in the pathogenesis of atherosclerosis and is accurately measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future risks of heart attacks and strokes.
Researchers from Florida Atlantic University’s Schmidt College of Medicine, Marshfield Clinic Research Institute, and the University of Wisconsin School of Medicine and Public Health, collaborated on a randomized trial titled, “Correlation between Oral Health and Systemic Inflammation” (COHESION), to further explore whether Plaque HD®, a plaque identifying toothpaste, reduces hs-CRP. Continue reading →
I have to admit that I have been seeing items and ads about CoQ10 for years and never paid it much attention. I stumbled across this rundown in Medical News Today and was amazed at its functionality. I thought it would interest you.
CoQ10 is an antioxidant that exists in almost every cell of the human body. CoQ10 deficiency is associated with various medical conditions, such as heart disease, cancer, and Alzheimer’s disease.
Although the body naturally produces CoQ10, some people may benefit from taking supplements. Overall, CoQ10 supplements appear relatively safe and cause few side effects. Supplements are not regulated by the Food and Drug Administration (FDA) for purity or verified for labeling accuracy, so purchase only those products that have been tested by an independent lab.
People who are interested in trying CoQ10 supplements may want to consult a healthcare professional first. Experts do not recommend CoQ10 for people taking blood-thinning medications, insulin, or certain chemotherapy drugs.Continue reading →
As if we didn’t have enough to worry about with our penchant for carrying too much weight, researchers using MRI have found signs of damage that may be related to inflammation in the brains of obese adolescents, according to a study being presented next week at the annual meeting of the Radiological Society of North America (RSNA).
Obesity in young people has become a significant public health problem. In the U.S., the percentage of children and adolescents affected by obesity has more than tripled since the 1970s, according to the Centers for Disease Control and Prevention. Data from the World Health Organization indicates that the number of overweight or obese infants and young children ages five years or younger increased from 32 million globally in 1990 to 41 million in 2016.
Reduction in fractional anisotropy (FA) in obese patients compared to the control group: At the intersection of the alignment vectors, a large cluster of FA decrease located in the corpus callosum on the left. In red: Reduction of FA in obese patients compared to controls, and FA skeleton (green), superimposed on the mean of FA images in sample. The image is credited to Study author and RSNA.
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
An estimated 12M UK citizens have a chronic medical condition, and many of them report severe mental fatigue that they characterize as ‘sluggishness’ or ‘brain fog’. This condition is often as debilitating as the disease itself.
A team in the University’s Center for Human Brain Health investigated the link between this mental fog and inflammation – the body’s response to illness. In a study published in Neuroimage, they show that inflammation appears to have a particular negative impact on the brain’s readiness to reach and maintain an alert state.
Dr Ali Mazaheri and Professor Jane Raymond of the University’s Centre for Human Brain Health, are the senior authors of the study. Dr Mazaheri says: “Scientists have long suspected a link between inflammation and cognition, but it is very difficult to be clear about the cause and effect. For example, people living with a medical condition or being very overweight might complain of cognitive impairment, but it’s hard to tell if that’s due to the inflammation associated with these conditions or if there are other reasons.” Continue reading →
I am a chocolate lover. I have some every day of my life. Granted, what I consume are small quantities which I devour slowly and let simply melt in my mouth. I also know that dark chocolate has more benefits than the sweet milk chocolate of my childhood. Herewith, Medical News Today‘s take on the dark delight.
Chocolate lovers, rejoice; the sweet treat is not only delicious, but studies show that it can also promote friendly bacteria and reduce inflammation in our guts. But first, some background: trillions of bacteria live in our guts. They contribute to our immune system, metabolism, and many other processes essential to human health.
When the delicate balance of microbes in our intestines is disturbed, it can have serious consequences.
Scientists have found that carrying fat around your middle could be as good an indicator of cancer risk as body mass index (BMI), according to research (link is external)* published in the British Journal of Cancer today (Wednesday).
“However you measure it being overweight or obese can increase the risk of developing certain cancers.” – Dr Julie Sharp, Cancer Research UK It shows that adding about 4.3 inches to the waistline increased the risk of obesity related cancers by 13 per cent.
For bowel cancer, adding around 3.15 inches to the hips is linked to an increased risk of 15 per cent.
Carrying excess body fat can change the levels of sex hormones, such as oestrogen and testosterone, can cause levels of insulin to rise, and lead to inflammation, all of which are factors that have been associated with increased cancer risk. Continue reading →
Running may also slow the process that leads to osteoarthritis
As regular readers know, I ride my bike nearly daily, here in Chicago. A hundred years ago, it seems, I ran daily. I stopped running because I enjoy bike riding more.
We all know that running causes a bit of inflammation and soreness, and that’s just the price you pay for cardiovascular health. You know; no pain, no gain.
Well, maybe not. New research from BYU exercise science professors finds that pro-inflammatory molecules actually go down in the knee joint after running.
In other words, it appears running can reduce joint inflammation.“It flies in the face of intuition,” said study coauthor Matt Seeley, associate professor of exercise science at BYU. “This idea that long-distance running is bad for your knees might be a myth.” Continue reading →
Foods are a wonderful place to start when you are looking to reduce inflammation in your body. What you eat on a daily basis will have a profound effect on your body’s ability to fight inflammation and prevent inflammation from happening. Through eating you literally change the chemistry of your body.
Inflammation can be caused many different factors. Scientifically speaking inflammation is a cascade of chemical reactions that happen within the body when there is damage done to cells, when there is an irritant present or when the body senses a foreign invader.
What Are The Symptoms Of Acute Inflammation?
The inflammation reaction is necessary and protective for the body in the short-term. Acute inflammation can leave you with the following cluster of symptoms: pain, redness, immobility, swelling and heat. This is due to the fact that large amounts of both red and white blood cells, lipoproteins, fluid and other body tissues are rushing to the site of injury in an attempt to repair damage and clear away foreign particles.
So What Is The Problem With Inflammation?
The problem with inflammation comes when it is prolonged or becomes chronic. It is meant to be a “first…
While inflammation is a protector of our health when it’s an acute response, chronic inflammation is a different story. A diverse group of medical illness are believed to be caused in part by chronic activation of the same chemical and cellular processes described above. These include asthma, acne, celiac disease, rheumatoid arthritis, and even atherosclerosis of heart arteries. In fact, in 1856 Rudolf Virchow proposed that arterial disease was an inflammation of blood vessels and now, over 150 years later, people who fear heart disease are routinely checked for this process.
Please check out A Beginner’s Guide to Earthing (Grounding) – Part One. I have been practicing Earthing since July and it definitely reduces inflammation in the body. It is like taking an antioxidant shower.
Regular readers of MindBodyGreen are aware that a process in our bodies called inflammation is involved in many aspects of human health and disease. For example, you may have read that a breakfast of Egg McMuffins, sleep apnea, obesity and ultra-exercise are inflammatory, while turmeric, meditation and the Mediterranean diet are anti-inflammatory, and so on. Lost in the search for vitality and longevity is an understanding of what inflammation is and what can be done to tame it. In many ways, inflammation is a Goldilocks process – you don’t want too much or too little, but just the right amount.
When I explain inflammation to patients, I point out that the middle of the word is “flame,” and that it comes from the Latin “I ignite.” Inflammation is a complex process of cells and chemicals in our bodies standing ready to fight…
May is Hepatitis awareness month. Millions of Americans are living with chronic viral hepatitis and many do not know that they are infected. Every year, approximately 15,000 Americans die from liver cancer or chronic liver disease associated with viral hepatitis. Despite this, viral hepatitis is not well known. In fact, as many as 75 percent of the millions of Americans with chronic viral hepatitis don’t know they’re infected.
The word “hepatitis” means inflammation of the liver. Hepatitis is most often caused by one of several viruses, which is why it is often called viral hepatitis.
The Centers for Disease Control offers a free Hepatitis Risk Assessment to find out if you should be tested for viral hepatitis. This risk assessment tool allows individuals to answer questions privately, either in their home or in a health care setting, and print their recommendations to discuss with their doctor. May 19 is National Hepatitis Testing Day.
You can take the free test by clicking on the link above.
This is not an easy question to answer. The National Sleep Foundation offers ranges for various ages, but with the range for adults being two whole hours, from seven to nine hours, it is certainly not definitive.
Time Magazine quoted Daniel Kripke, co-director of research at the Scripps Clinic Sleep Center in La Jolla, Calif., who compared death rates among more than one million American adults who reported their average nightly amount of sleep. While his results were surprising, they have since been corroborated by similar studies in Europe and East Asia.
“Studies show that people who sleep between 6.5 hr. and 7.5 hr. a night, as they report, live the longest. And people who sleep 8 hr. or more, or less than 6.5 hr., they don’t live quite as long. There is just as much risk associated with sleeping too long as with sleeping too short. The big surprise is that long sleep seems to start at 8 hr. Sleeping 8.5 hr. might really be a little worse than sleeping 5 hr.” Kripke said.
“Morbidity [or sickness] is also “U-shaped” in the sense that both very short sleep and very long sleep are associated with many illnesses—with depression, with obesity—and therefore with heart disease—and so forth. But the [ideal amount of sleep] for different health measures isn’t all in the same place. Most of the low points are at 7 or 8 hr., but there are some at 6 hr. and even at 9 hr. I think diabetes is lowest in 7-hr. sleepers [for example]. But these measures aren’t as clear as the mortality data.”
The best explanation I have heard was from Associate Professor Ramadevi Gourineni in Neurology and Director of the Insomnia Program speaking before the Northwestern Memorial Hospital’s Healthy Transitions Program®. In answer to the question how much sleep do I need, she offered, “The amount that permits us to be wide awake, alert and energetic throughout the day. This amount varies from person to person and may be genetically determined.” She also noted that not only do we need the proper quantity of sleep, but also the proper quality of sleep. Continue reading →