Because of the dementia and Alzheimer’s Disease in my family, I have an appetite for information on impaired cognition. Following comes from a study by the VA San Diego Healthcare System. Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.
The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology.
Participants had brain scans at the start of the study to determine levels of amyloid plaques in the brain, and then yearly scans for four years. Image is in the public domain.
“Our research was able to detect subtle thinking and memory differences in study participants and these participants had faster amyloid accumulation on brain scans over time, suggesting that amyloid may not necessarily come first in the Alzheimer’s disease process,” said study author Kelsey R. Thomas, PhD, of the VA San Diego Healthcare System in San Diego. “Much of the research exploring possible treatments for Alzheimer’s disease has focused on targeting amyloid. But based on our findings, perhaps that focus needs to shift to other possible targets.” Continue reading
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
An estimated 12M UK citizens have a chronic medical condition, and many of them report severe mental fatigue that they characterize as ‘sluggishness’ or ‘brain fog’. This condition is often as debilitating as the disease itself.
A team in the University’s Center for Human Brain Health investigated the link between this mental fog and inflammation – the body’s response to illness. In a study published in Neuroimage, they show that inflammation appears to have a particular negative impact on the brain’s readiness to reach and maintain an alert state.
Dr Ali Mazaheri and Professor Jane Raymond of the University’s Centre for Human Brain Health, are the senior authors of the study. Dr Mazaheri says: “Scientists have long suspected a link between inflammation and cognition, but it is very difficult to be clear about the cause and effect. For example, people living with a medical condition or being very overweight might complain of cognitive impairment, but it’s hard to tell if that’s due to the inflammation associated with these conditions or if there are other reasons.” Continue reading
Artificial intelligence helps shed light on how people’s brains, bodies, and emotions react to listening to music. Music influences parts of the auditory cortex, including the Heschl’s gyrus and superior temporal gyrus, specifically responding to pulse clarity. Changes in dynamics, rhythm, timbre, and the introduction of new instruments cause an uptick in the response. The study also identified the best song types for the perfect workout, sleep, and study.
Your heart beats faster, palms sweat and part of your brain called the Heschl’s gyrus lights up like a Christmas tree. Chances are, you’ve never thought about what happens to your brain and body when you listen to music in such a detailed way.
But it’s a question that has puzzled scientists for decades: Why does something as abstract as music provoke such a consistent response? In a new study, a team of USC researchers, with the help of artificial intelligence, investigated how music affects listeners’ brains, bodies and emotions.
The research team looked at heart rate, galvanic skin response (or sweat gland activity), brain activity and subjective feelings of happiness and sadness in a group of volunteers as they listened to three pieces of unfamiliar music. Continue reading