Working with their colleagues at the University of Pennsylvania, researchers at the University of Kentucky have found that they can differentiate between sub-types of dementia inducing brain disease.
“For the first time we created criteria that could differentiate between frontotemporal dementia (FTD) and a common Alzheimer’s ‘mimic’ called LATE disease,” said Dr. Peter Nelson of the Sanders-Brown Center on Aging at the University of Kentucky. He says they validated the criteria rigorously. The study was recently published in BRAIN: A Journal of Neurology. The first author of the paper was John L. Robinson from the University of Pennsylvania and the corresponding author was Nelson.
The living brain is constantly producing regular rhythmic patterns of activity, which can be compared to musical notes. Scientists at the University of Birmingham in the UK, and the University of Maryland School of Dentistry in the U.S., have successfully demonstrated that one particularly prevalent pattern of brain activity, called alpha waves, strongly relates to the body’s susceptibility or resilience to pain.
Alpha waves oscillate between 8-14 Hz, with the peak frequency varying across individuals. The researchers demonstrated how a measurement of an individual’s alpha wave frequency can be used as a reliable pain indicator.
The study, led by graduate student Andrew Furman and published in the journal Cerebral Cortex, suggests that these alpha waves could be used to help clinicians understand how susceptible a patient to experience severe pain post-surgery.
A new analysis published in the journal Psychological Science in the Public Interest (PSPI), however, reveals that even though a more extensive formal education forestalls the more obvious signs of age-related cognitive deficits, it does not lessen the rate of aging-related cognitive declines. Instead, people who have gone further in school attain, on average, a higher level of cognitive function in early and middle adult adulthood, so the initial effects of cognitive aging are initially less obvious and the most severe impairments manifest later than they otherwise would have.
“The total amount of formal education that people receive is related to their average levels of cognitive functioning throughout adulthood,” said Elliot M. Tucker-Drob, a researcher with the University of Texas, Austin, and coauthor on the paper. “However, it is not appreciably related to their rates of aging-related cognitive declines.”Continue reading →
It’s never too late to lace up some sneakers and work up a sweat for brain health, according to a study published in the May 13, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study suggests older adults, even couch potatoes, may perform better on certain thinking and memory tests after just six months of aerobic exercise.
“As we all find out eventually, we lose a bit mentally and physically as we age. But even if you start an exercise program later in life, the benefit to your brain may be immense,” said study author Marc J. Poulin, Ph.D., D.Phil., from the Cumming School of Medicine at the University of Calgary in Alberta, Canada. “Sure, aerobic exercise gets blood moving through your body. As our study found, it may also get blood moving to your brain, particularly in areas responsible for verbal fluency and executive functions. Our finding may be important, especially for older adults at risk for Alzheimer’s and other dementias and brain disease.”
Genes and cardiovascular health each contribute in an additive way to a person’s risk of dementia, U.S. researchers including Sudha Seshadri, MD, and Claudia Satizabal, PhD, of The University of Texas Health Science Center at San Antonio (UT Health San Antonio) reported July 20 in the journal Neurology.
The study was conducted in 1,211 participants in the Framingham Heart Study and involved collaborators from Boston University.
Participants with a high genetic risk score based on common genetic variants, including having an allele called apolipoprotein E (APOE) ε4, were at a 2.6-fold higher risk of developing dementia than subjects who had a low risk score and did not carry the APOE ε4 allele.
Researchers at Center for BrainHealth®, part of The University of Texas at Dallas, recently examined underlying brain networks in long-term cannabis users to identify patterns of brain connectivity when the users crave or have a desire to consume cannabis. While regional brain activation and static connectivity in response to cravings have been studied before, fluctuations in brain network connectivity had not yet been examined in cannabis users. The findings from this study will help support the development of better treatment strategies for cannabis dependence.
The study was published in the journal of Human Brain Mapping (May 2020) by researchers Francesca Filbey, PhD, professor and director of cognitive neuroscience research of addictive disorders at Center for BrainHealth, Hye Bin Yoo, PhD and Blake Edward Moya.
By the time people reach a certain age, they’ve accumulated enough life experience to have plenty of stories to tell about life “back in their day.”
However, a new study suggests that the older a person is, the less likely they are to share memories of their past experiences. And when they do share memories, they don’t describe them in as much detail as younger people do.
The results of the study, conducted by researchers at the University of Arizona and published in the journal Frontiers in Human Neuroscience, echo previous findings from lab-based research suggesting that memory sharing declines with age.
The UArizona study came to the conclusion in a new way: by “eavesdropping” on older adults’ conversations “in the wild.”
Because of the dementia and Alzheimer’s Disease in my family, I have an appetite for information on impaired cognition. Following comes from a study by the VA San Diego Healthcare System. Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.
The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology.
Participants had brain scans at the start of the study to determine levels of amyloid plaques in the brain, and then yearly scans for four years. Image is in the public domain.
“Our research was able to detect subtle thinking and memory differences in study participants and these participants had faster amyloid accumulation on brain scans over time, suggesting that amyloid may not necessarily come first in the Alzheimer’s disease process,” said study author Kelsey R. Thomas, PhD, of the VA San Diego Healthcare System in San Diego. “Much of the research exploring possible treatments for Alzheimer’s disease has focused on targeting amyloid. But based on our findings, perhaps that focus needs to shift to other possible targets.” Continue reading →
Scientists at the University of Birmingham in collaboration with the University of Amsterdam have uncovered a possible explanation for the mental sluggishness that often accompanies illness.
An estimated 12M UK citizens have a chronic medical condition, and many of them report severe mental fatigue that they characterize as ‘sluggishness’ or ‘brain fog’. This condition is often as debilitating as the disease itself.
A team in the University’s Center for Human Brain Health investigated the link between this mental fog and inflammation – the body’s response to illness. In a study published in Neuroimage, they show that inflammation appears to have a particular negative impact on the brain’s readiness to reach and maintain an alert state.
Dr Ali Mazaheri and Professor Jane Raymond of the University’s Centre for Human Brain Health, are the senior authors of the study. Dr Mazaheri says: “Scientists have long suspected a link between inflammation and cognition, but it is very difficult to be clear about the cause and effect. For example, people living with a medical condition or being very overweight might complain of cognitive impairment, but it’s hard to tell if that’s due to the inflammation associated with these conditions or if there are other reasons.” Continue reading →
Artificial intelligence helps shed light on how people’s brains, bodies, and emotions react to listening to music. Music influences parts of the auditory cortex, including the Heschl’s gyrus and superior temporal gyrus, specifically responding to pulse clarity. Changes in dynamics, rhythm, timbre, and the introduction of new instruments cause an uptick in the response. The study also identified the best song types for the perfect workout, sleep, and study.
Your heart beats faster, palms sweat and part of your brain called the Heschl’s gyrus lights up like a Christmas tree. Chances are, you’ve never thought about what happens to your brain and body when you listen to music in such a detailed way.
But it’s a question that has puzzled scientists for decades: Why does something as abstract as music provoke such a consistent response? In a new study, a team of USC researchers, with the help of artificial intelligence, investigated how music affects listeners’ brains, bodies and emotions.
The research team looked at heart rate, galvanic skin response (or sweat gland activity), brain activity and subjective feelings of happiness and sadness in a group of volunteers as they listened to three pieces of unfamiliar music. Continue reading →