A new study reveals blood cell DNA remains steady, even after transplant. The findings shed new light on human aging. Source: Case Western Reserve University.
Blood cells could hold the key to aging, according to new research out of Case Western Reserve University School of Medicine. In a study published in Aging Cell, researchers found human blood cells have an intrinsic clock that remains steady even after transplant. The researchers say the clock could control human aging and may underlie blood cancers.
Their inherent steadiness suggests blood cells could be the master clock of human aging, as they are not easily influenced by their environment, Matsuyama said. NeuroscienceNews.com image is in the public domain.
Shigemi Matsuyama, DVM, PhD, cell biologist and associate professor of medicine at Case Western Reserve University School of Medicine, led an international team of researchers in studying the clock. The team measured cellular age in blood cells transplanted from healthy donors to leukemia patients, focusing on donor-recipient pairs of very different ages. Continue reading
Herewith the latest development in our battle with Father Time. At 78-years-old, this is the kind of information that keeps me on the edge of my seat.
As people age, their blood-vessel density and blood flow decrease, which is why it’s harder to maintain muscle mass after 40 and endurance in the later decades, even with exercise. This vascular decline is also one of the major causes of age-related diseases, such as frailty or hypertension. However, little is known about the underlying cause or how to stop it.
Now, in a new study published this week in Cell, a team of researchers from Penn Medicine and other institutions have shown for the first time how a well-studied enzyme called SIRT1 declines in the blood vessels with age and that restoring it reverses the effects of vascular aging. After receiving a supplement called NAD+ precursor nicotinamide mononucleotide (NMN), older mice had the number of capillaries and capillary density found in much younger mice, and improved endurance by up to 80 percent. The collaborative study also involves researchers from Harvard Medical School and Massachusetts Institute of Technology.
“This study tells us that the loss of SIRT1 is a primary reason why our ability to exercise and receive its benefits diminish as we age,” said co-senior author Zoltan Pierre Arany, MD, PhD, an associate professor of Cardiovascular Medicine in the Perelman School of Medicine at the University of Pennsylvania. “We also show that when we bring the enzyme back into the blood vessels, vascular health improves dramatically: The old blood vessel tree [cluster of capillaries] in the older mice is turned into a young vessel tree, one that looks like it’s been exercising for a while, just by turning on this enzyme. That’s the most powerful aspect of the study.” Continue reading
I get blood work done at least once a year and confess that I do not know what all the information they get means. Thought this piece from Medical News Today might be useful in that regard.
Doctors regularly order blood tests to get an idea of the overall health of their patients.
One of the things they check for is MCH levels.
These levels are regularly used to help diagnose blood disorders but can be difficult to understand. Different MCH levels may cause a variety of symptoms, which will require individual treatments.
What is MCH?
MCH stands for mean corpuscular hemoglobin.
MCH levels refer to the average amount of hemoglobin found in the red blood cells in the body. Hemoglobin is a protein in the blood that allows red blood cells to deliver oxygen to the cells and tissues in the body.
What is a CBC test?
A complete blood count test, or simply CBC test, is designed to give doctors a general overview of a person’s health. The test can help screen people for a variety of issues at once and may help diagnose conditions, such as bleeding disorders, infections, and anemia. Continue reading