Some of the lowest rates of heart and brain disease ever reported by science are found among Indigenous communities inhabiting the tropical forests of lowland Bolivia. New USC research on two of these societies, the Tsimané and Mosetén, suggests that there are optimal levels of food consumption and exercise that maximize healthy brain aging and reduce the risk of disease.

The study appears on Monday, March 20 in Proceedings of the National Academy of Sciences.
Thanks to industrialization, humans now enjoy greater access to food, less physical toil and better access to health care than ever before. However, we’ve grown accustomed to eating more and exercising less. Obesity and sedentary lifestyles are associated with smaller brain volumes and faster cognitive decline.
To better understand the tipping point where abundance and ease begin to undermine health, the researchers enrolled 1,165 Tsimané and Mosetén adults, aged 40-94 years, and provided transportation for participants from their remote villages to the closest hospital with CT scanning equipment.