Enhancing Deep Sleep

The first clinical study

Researchers from ETH Zurich and University Hospital Zurich, led by Caroline Lustenberger, group leader at the Neural Control of Movement Lab, have conducted a clinical study with this device for the first time. The results have just been published in the journal Communications Medicinecall_made.

The study involved equipping participants, between 60 – 80 years old, with the SleepLoop system, which they were required to operate themselves in their own home. The system is designed to function independently even by users with little technical experience. “This worked very well. We had surprisingly little data loss and the participants rated the device as user-​friendly,” says Lustenberger.

Bonnet on before going to bed: The device is designed to be as easy to use as possible. (Photograph: SleepLoop) They wore the device every night for a total of four weeks, with the auditory stimulation given on a nightly basis for two weeks and no stimulation for the next two weeks. Neither the subjects nor the researchers knew in which two weeks the auditory signals were played and in which two they were not.

Auditory stimulation is indeed feasible

The results of 16 participants of the study show that it was indeed possible to enhance the slow waves through auditory signals during deep sleep in most participants. However, the individual differences were extensive with some of the subjects responding very well to the stimuli, while others responded minimally or not at all.

According to Lustenberger, the question of whether a person reacted to a stimulus did not depend on their well-​being during the day. “Some people generally responded well to the stimuli and clearly showed enhanced slow waves, while others showed no response, regardless of their daily well-​being.”

The researchers have used these individual differences to better predict how a given individual will respond to the auditory stimulus. This in turn helps them to optimise and improve the performance of SleepLoop.

On track for market launch

A spin-​off company Tosoo AG, is currently working on developing the device further and preparing it for the clinical market. It is already clear that it will not be freely available, but only via a doctor’s prescription.

“This is a medical device, not just a wellness consumer product you can order online when you have trouble sleeping,” emphasizes Walter Karlen, who developed the technology at ETH Zurich. 1 Karlen has been appointed Director of the Institute of Biomedical Engineering at Ulm University in May 2021. “Use of the device must be medically indicated and supervised by a doctor”, he says. Further development of the technology will now continue also in Ulm.