Extended Napping in Seniors May Signal Dementia

The device was worn every year continuously for up to 14 days, and once a year each participant underwent a battery of neuropsychological tests to evaluate cognition. At the start of the study, 75.7% of participants had no cognitive impairment, while 19.5% had mild cognitive impairment and 4.1% had Alzheimer’s disease.

For participants who did not develop cognitive impairment, daily daytime napping increased by an average 11 minutes per year. The rate of increase doubled after a diagnosis of mild cognitive impairment to a total of 24 minutes and nearly tripled to a total of 68 minutes after a diagnosis of Alzheimer’s disease.

When the researchers looked at the 24% of participants who had normal cognition at the start of the study but developed Alzheimer’s six years later, and compared them with those whose cognition remained stable, they found differences in napping habits. Participants who napped more than an hour a day had a 40% higher risk of developing Alzheimer’s than those who napped less than an hour a day; and participants who napped at least once a day had a 40% higher risk of developing Alzheimer’s than those who napped less than once a day.

The research confirms the results of a 2019 study, of which Leng was the first author, that found older men who napped two hours a day had higher odds of developing cognitive impairment that those who napped less than 30 minutes a day. The current study builds on these findings by evaluating both daytime napping and cognition each year, hence addressing directionality, Leng notes.

Loss of Wake-Promoting Neurons May Account for Longer Naps

According to the researchers, increase in napping may be explained by a further 2019 study, by other UCSF researchers, comparing the postmortem brains of people with Alzheimer’s disease to those without cognitive impairment. Those with Alzheimer’s disease were found to have fewer wake-promoting neurons in three brain regions. These neuronal changes appear to be linked to tau tangles – a hallmark of Alzheimer’s, characterized by increased activity of enzymes causing the protein to misfold and clump.

“It is plausible that our observed associations of excessive daytime napping at baseline, and increased risk for Alzheimer’s disease during follow-up, may reflect the effect of Alzheimer’s disease pathology at preclinical stages,” the authors noted.

The study shows for the first time that napping and Alzheimer’s disease “seem to be driving each other’s changes in a bi-directional way,” said Leng, who is also affiliated with the UCSF Weill Institute for Neurosciences. “I don’t think we have enough evidence to draw conclusions about a causal relationship, that it’s the napping itself that caused cognitive aging, but excessive daytime napping might be a signal of accelerated aging or cognitive aging process,” she said.

“It would be very interesting for future studies to explore whether intervention of naps may help slow down age-related cognitive decline.”