Poor Score on Simple Memory Test May Be Linked to Alzheimer’s Biomarkers

Among people with no memory or thinking problems, having a poor score on a simple memory test may be linked to biomarkers in the brain associated with Alzheimer’s disease as well as very early signs of memory impairment that precede dementia by several years, according to a study published in the February 23, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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“These findings suggest that this test can be used to improve our ability to detect cognitive decline in the stage before people are diagnosed with Alzheimer’s disease,” said study author Ellen Grober, PhD, of Albert Einstein College of Medicine in the Bronx, New York. “This could be helpful in determining who to enroll in clinical trials for prevention of cognitive decline. It could also help by narrowing down those who already have signs of Alzheimer’s in the brain with a simple test rather than expensive or invasive scans or lumbar punctures.”

For the test, people are shown pictures of items and given cues about the item’s category, such as a picture of grapes with the cue of “fruit.” Then participants are asked to remember the items, first on their own, then with the category cues for any items they did not remember. This type of controlled learning helps with the mild memory retrieval problems that occur in many healthy elderly people but does not have much impact on memory for people with dementia, Grober said.

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