Could Healthy Gut Microbes Help Preserve Muscle as We Age? – Tufts

One factor believed to contribute to sarcopenia is the level of general inflammation in the body, which increases with age. Scientists have found changes in the gut microbiota in older adults that could cause the intestinal walls to become more permeable, allowing inflammation-promoting factors to enter circulation. In other words, age-related changes in the gut microbiome could lead to increased inflammation, which in turn may contribute to loss of muscle. Change in muscle composition (fat building up in muscle tissue) has also been implicated in loss of strength and function with age. Studies in rodents and pigs suggest several pathways by which gut bacteria may influence the change in muscle composition.

Lustgarten and his colleagues are currently conducting research to gather more information on the gut-muscle connection. “I see promising data emerging from the human studies that are underway. We need additional studies to provide more information and, ideally, to prove cause and effect,” says Lustgarten.

A Role for Diet: Our dietary intake can impact the make-up of our gut microbiome. Foods with live cultures, such as many yogurts, contribute live bacteria that help populate the gut. Fermented foods, including hard cheese and kambucha tea, also contain live organisms (as long as they have not been heat treated). Naturally fiber-rich foods are a key component of gut-microbe-supporting dietary patterns. Fibers are prebiotics, compounds that nourish microorganisms. Because they cannot be broken down by digestion, fibers reach the lower intestines intact, where they serve as food for gut bacteria. Several studies have demonstrated that feeding prebiotic fibers to mice alters the gut microbiota in ways that decrease inflammation and potentially protects against age-related muscle atrophy. A 2009 study in the journal Gut reported an increase in muscle mass in obese mice fed the prebiotic fiber oligofructose (which is found naturally in foods such as bananas, onions, garlic, asparagus, wheat, and barley). Note that added fibers may not have the same general health benefits as the fibers found naturally in whole foods, and many foods with added fiber may also have high levels of added sugar and/or sodium.

It’s important to keep in mind that most research on the gut-muscle connection has been done in mice, rats, and pigs. The results may not translate to humans and do not prove cause and effect, but they open the door to the exciting idea that diet could someday be used to slow the aging process by altering the composition of gut bacteria. A dietary pattern high in naturally high-fiber foods (and low in highly-processed refined foods) has many known health benefits—now we can add the possibility that it may even help keep us strong and fit.

TAKE CHARGE

Follow these tips to preserve muscle with age:

-ADD STRENGTH TRAINING— using weights,machines, or your own body weight—at leasttwo days a week.

-BE GENERALLY ACTIVE, whether by walking,dancing, working, or playing, to keep thosemuscles moving.

-CHOOSE HIGH-FIBER FOODS like fruits,vegetables, legumes, and whole grains. Thesefoods have health benefits in their own right,and help maintain healthy gut microbes whichmay play a role in muscle structure and function.

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