Hopes for pandemic respite this spring may depend upon what happens indoors

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The cold, dry air of winter clearly helps SARS-CoV2 — the virus that causes COVID-19 — spread among people, Yale research has shown. But as humidity increases during spring and summer, the risk of transmission of the virus through airborne particles decreases both outside and indoors in places such as offices.

While viruses can still be transmitted through direct contact or through contaminated surfaces as humidity rises, researchers suggest that, in addition to social distancing and hand washing, the seasonal moderation of relative humidity – the difference between outside humidity and temperatures and indoor humidity – could be an ally in slowing rates of viral transmission.

The review was published online the week of March 23 in the Annual Review of Virology.

“Ninety percent of our lives in the developed world are spent indoors in close proximity to each other,” said Yale immunobiologist and senior author Akiko Iwasaki. “What has not been talked about is the relationship of temperature and humidity in the air indoors and outdoors and aerial transmission of the virus.”

Iwasaki is the Waldemar Von Zedtwitz Professor of Immunobiology and professor of molecular, cellular, and developmental biology at Yale, and an investigator for the Howard Hughes Medical Institute.

Iwasaki said the seasonal nature of respiratory illnesses have been chronicled since the times of the ancient Greeks, who noted such illnesses rose in winter and fell during spring and summer. Modern science has been able to identify cold, dry air as a factor in spread of viruses such as the novel coronavirus causing COVID-19. Research by Iwasaki’s lab and others explains why.

Winter’s cold, dry air makes such viruses a triple threat, Iwasaki said: When cold outdoor air with little moisture is heated indoors, the air’s relative humidity drops to about 20%. This comparatively moisture-free air provides a clear path for airborne viral particles of viruses such as COVID-19..

Warm, dry air also dampens the ability of cilia, the hair-like projections on cells lining airways, to expel viral particles. And lastly, the immune system’s ability to respond to pathogens is suppressed in drier environments, Iwasaki has found.

Iwasaki was interested in the effects of relative humidity During the winter, relative humidity remains low in most indoor environments; the cold, dry outside air is simply reheated and circulated throughout homes and offices.

Iwasaki’s review cites experiments that show rodents infected with respiratory viruses can easily transmit viral particles through the air to non-infected neighbors in low-humidity environments.

“That’s why I recommend humidifiers during the winter in buildings,” Iwasaki said.

However, in areas of high relative humidity such as the tropics, airborne infectious droplets fall onto surfaces indoors and can survive for extended periods, she said.

“Many homes and buildings are poorly ventilated and people often live in close proximity, and in these cases, the benefits of higher humidity are mitigated,” Iwasaki said.

There is a sweet spot in relative humidity for indoor environments, review found. Mice in environments of between 40% and 60% relative humidity show substantially less ability to transmit viruses to non-infected mice than those in environments of low or high relative humidity. Mice kept at 50% relative humidity were also able to clear an inhaled virus and mount robust immune responses, she found.

Iwasaki stresses that these studies only apply to aerosol transmission: the virus still can be shared at any time of year between people in close proximity and through contact with surfaces containing sufficient amounts of virus. That is why people living in warm countries and people working close to each other are still susceptible to infection, she said.

“It doesn’t matter if you live in Singapore, India, or the Arctic, you still need to wash your hands and practice social distancing,” Iwasaki said.


Filed under coronavirus, coronavirus risk, COVID-19, pandemic

2 responses to “Hopes for pandemic respite this spring may depend upon what happens indoors

  1. Wayne Blankenbiller

    staying safe

    On Mon, Mar 30, 2020 at 11:06 PM One Regular Guy Writing about Food, Exercise and Living Past 100 wrote:

    > Tony posted: ” How much spring and summer affect the COVID-19 pandemic may > depend not only on the effectiveness of social distancing measures, but > also on the environment inside our buildings, according to a review of Yale > scientists of their own work and that of coll” >


  2. Excellent post, Tony.

    Liked by 1 person

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