Secrets to our smarts hidden in the folds of our cortex

I am keenly interested in the brain as I have a history of Alzheimer’s Disease and dementia on both sides of my family. That is one of the reasons that I exercise religiously. To read more about the brain and exercise, check out my Page – Important facts about your brain (and exercise benefits).

Here is the latest from the National Institute of Mental Health. brain_illo_news


The more folding in the thinking parts of our brain, the smarter we are – to a degree. That’s the take-home of by far the largest study of its kind into the connection between such brain gyrification and human intelligence.

Karen Berman, M.D., Michael Gregory, M.D., of the NIMH Section on Integrative Neuroimaging, and colleagues, report on their magnetic resonance imaging findings online April 28, 2016 in the journal Current Biology.

Increasing gyrification in a network of regions in the human brain’s outer mantle is significantly associated with general cognitive ability, a finding replicated in 440 healthy adults and in an independent sample of 662 healthy children who underwent structural MRI scans and extensive neuropsychological testing. The cortex maps showing networks in which gyrification correlates with intelligence are remarkably similar across the two groups. The relationship was also consistent across sexes, the age span, and different methods of estimating intelligence.

“The areas in which intelligence correlated with folding share in common the ability to process information from multiple sensory modalities,” explained Gregory. “These results are consistent with evidence across species and fit well into an evolutionary context.”
The findings support the theory that intelligence hinges on interactions between the brain’s parietal and frontal lobes. These cortex areas are comprised of six cellular layers that underwent rapid expansion through human evolution. Folding presumably enabled burgeoning circuitry to fit within the confines of the skull.

The results add to evidence that regions of the brain that each take in information from just one sense, which are comprised of fewer layers, feed it to the parietal lobe for abstraction and elaboration. Interactions between the highly-folded tissues of the parietal and frontal lobes test hypotheses about the information and make decisions, which are then translated into responses by the cingulate cortex. Added to evidence from comparative biology, the findings suggest that folding in these particular brain regions shows a stronger connection to intelligence than overall brain size.

However, the connection to folding accounted for only 6-12 percent of variation in general intelligence, leaving much of such variance attributable to a variety of other factors, including environment. Still, the researchers say their MRI maps hold potential insights into the cellular architecture of specialization in the human brain.


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