Being Overweight in Midlife May Increase Alzheimer’s Risk – Study

As if we didn’t need another reason to control our weight, the National Institute on Aging reports that being overweight may increase our risk for Alzheimer’s Disease and dementia.
obese“Being obese or overweight in middle age has been linked to increased risk of dementia. To learn more, researchers at the National Institute on Aging, part of the NIH, further explored the relationship between weight at midlife and Alzheimer’s among volunteers participating in the Baltimore Longitudinal Study of Aging (BLSA), one of the longest running studies of human aging in North America. They found that being obese or overweight at midlife—as measured by body mass index (BMI) at age 50—may predict earlier age of onset of the devastating neurodegenerative disorder.”

The study led by Madhav Thambisetty, M.D., Ph.D., appeared online Sept. 1, 2015, in Molecular Psychiatry.

“Cognitively healthy at the start of the nearly 14-year study, each of the 1,394 BLSA participants received cognitive testing every one to two years; 142 volunteers eventually developed Alzheimer’s disease.

The investigators found:
▪Each unit increase in BMI at age 50 accelerated onset by nearly 7 months in those who developed Alzheimer’s disease.
▪Higher midlife BMI was associated with greater levels of neurofibrillary tangles—a hallmark of the disease—in the brains of 191 volunteers, including those who did not develop Alzheimer’s.
▪Among 75 cognitively healthy volunteers who had brain imaging to detect amyloid, a protein whose fragments make up the brain plaques that are a hallmark of Alzheimer’s, those with higher midlife BMI had more amyloid deposits in the precuneus, a brain region that often shows the earliest signs of Alzheimer’s-related changes.”

Eat less; move more; live longer.

To read further about keeping your brain healthy, check out my Page – Important Facts About Your Brain (and Exercise Benefits).



Filed under Alzheimer's risk, overweight

2 responses to “Being Overweight in Midlife May Increase Alzheimer’s Risk – Study

  1. I wonder how much of weight is cause or effect… It is well-known that fitness wards off the onset of Alzheimer’s. Fit people generally aren’t overweight, so is it the fitness or fat? Know what I mean?


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